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금속의 절삭성 평가를 위한 2-3차원 어트랙터 시스템의 구축
윤인식,이종대 한국공작기계학회 2005 한국생산제조학회지 Vol.14 No.2
This study proposes the construction of 2-3 dimensional attractor system for cutting characteristics evaluation of metals. Also this paper aims to find the optimal cutting conditions of diamond turning machine by measuring surface form and roughness to perform the cutting experiment of metals, which are aluminum, with diamond tool. As well, according to change cutting conditions such as feed rate, using diamond turning machine to perform cutting processing, by measuring cutting force and surface roughness and according to cutting conditions the aluminum about cutting properties. Trajectory changes in the attractor indicated a substantial difference in attractor characteristics. Constructed 2-3 dimensional attractor system in this study can be used for cutting characteristics evaluation of metals.
윤인식,유영철,김스티브성,게리리드 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1
Many cast iron parts are welded and suffer from improper pre-heating and poor welding skills which destroy the castings due to new cracks, deformations etc. This is due mainly to the lack of understanding of the properties of cast iron. Welding, however impractical, was the only alternative for many years. Locks are used to add strength across a crack. Special drilling jigs are used to create a precise hole pattern that locks are driven into. Our locks have a unique ability to pull the sides of a crack together. Bottom locks are stacked or laminated to a depth of 80% of the casting thickness. Thicker surface locks finish off lock installation, allowing repairs in irregular shapes and contours. Installing products can be done quickly with pneumatic tools. Up to one inch of repair can be done in 5 minutes in 1/4" thick cast iron.
신경회로망과 경계요소법을 이용한 원공에서 파생하는 2차원 탄성균열의 응력세기계수 예측 모델링
윤인식,이원,Yun, In-Sik,Yi, Won 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.3
Recently the boundary element method has been developed swiftly. The boundary element method is an efficient and accurate means for analysis of two dimensional elastic crack problems. This paper is concerned with the evaluation and the prediction of the stress intensity factor(SIF) for the crack emanating from the circular hole using boundary element method-neural network. The SIF of the crack emanating from the hole was calculated by using boundary element method. Neural network is used to evaluate and to predict SIF from the results of boundary element method. The organized neural network system (structure of four processing element) was learned with the accuracy 99%. The learned neural network system could be evaluated and predicted with the accuracy of 83.3% and 71.4% (in cases of SIF and virtual SIF). Thus the proposed boundary element method-neural network is very useful to estimate the SIF.
골괴사를 동반한 만성 방사선 궤양의 치료를 위한 피판술
윤인식,이원재,정희선,유대현,탁관철 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.2
Purpose: While radiotherapy remains an essential part of the multidisciplinary treatment of cancers, it may cause unwanted consequences such as tissue break down and chronic non-healing wounds as a result of hypoxia, hypovascularity, and hypocellularity. The conservative treatment of osteoradionecrosis was effective only in the early stages or has a limited result. The surgical treatment of osteoradionecrosis includes various local fasciocutaneous flaps, local myocutaneous flaps and different kinds of free flaps with cancellous bone graft or alloplastic material after removal of all devitalized tissue. This study reviews recent cases of osteoradionecrosis in Severance hospital and investigates the use of various flaps for reconstruction of osteoradionecrosis.Methods: From 2000 to 2006, a total of 29 patients, nine men and twenty women with a mean age of 60.4 years were identified and included in the study. Fasciocutaneous flaps were used on 7 patients and myocutaneous flaps were used on the remaining patients. Mean follow-up period was 10.4 months.Results: In the fasciocutaneous flap group, we noted two complications including total flap failure and a partial flap necrosis. In the myocutaneous flap group, four complications were noted including a partial flap necrosis and 3 cases of wound dehiscence. Considering the complications noted in this study, the natural history of progression to flap necrosis appeared to follow the following sequence of events: marginal flap necrosis, infection, wound dehiscence, flap floating and partial flap necrosis, serially. Conclusion: Successful surgical treatment of osteoradionecrosis includes wide radical debridement and reconstruction with a well vascularized flap like myocutaneous flap or fasciocutaneous flap.
Relaxin을 분비하는 아데노바이러스가 피판의 생존에 미치는 영향
윤인식,박용순,전영우,전여름,이원재,윤채옥,나동균,Yun, In-Sik,Park, Yong-Sun,Cheon, Young-Woo,Jeon, Yeo-Reum,Lee, Won-Jai,Yun, Chae-Ok,Rah, Dong-Kyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.5
Purpose: Of various effects of relaxin, we assumed that anti-fibrotic effects, neovascularization effects and vasodilatation effects of relaxin might enhance the survival rate of skin flap. In the current study, we used adenovirus expressing relaxin genes to examine whether these genes could enhance the survival rate of a skin flap. Methods: A total of 30 Sprangue-Dawley rats were divided into three groups: RLX group (10; relaxin virus injected group), CTR group (10; no gene coded virus injection group), and PBS group (10; PBS injected group). Each group was intradermally injected with the virus ($10^7$ PFU) and PBS 48 hours before and immediately before the flap elevation. A distally based flap $3{\times}9\;cm$ in size was elevated on the dorsal aspect of each rat. Following this, a flap was placed in the original location and then sutured using a #4-0 Nylon. A surviving area of the flap was measured and then compared on postoperative days 3, 7 and 10. Using a laser Doppler, the amount of blood flow was measured. On postoperative day 10, tissues were harvested for histologic examination and the number of blood vessels was counted. Results: There was a significant increase in the area of the flap survival in the RLX group on postoperative days 3 and 7. The Doppler measurement also showed significantly increased blood flow immediately after the operation and on postoperative days 7 and 10. The number of blood vessels was significantly greater in the RLX group in the tissue harvested on postoperative day 10. The VEGF concentration was significantly higher in the RLX group than others in the tissues harvested on postoperative day 10. Conclusion: Following an analysis of the effects of relaxin-secreting adenovirus on the survival of a flap, the surviving area of the flap and the blood flow also increased. A histopathology also showed an increase in the number of blood vessels and the concentration of VEGF.
윤인식,강은혜,안효민,김용욱,나동균,노태석,이원재,윤채옥 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.9
Purpose: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagenre-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads) are accepted vectors for cancer genetherapy. However, repeated treatments of Ad are limited by short-term biological activity in vivo. The efficacy of sustained RLX expressionto scar remodeling was assessed using an injectable alginate gel-matrix system. Materials and Methods: Pig scar tissue was treated with relaxin-expressing Ad loaded in alginate gel (gel/Ad-RLX). Surface areas,color, and pliability of scars were compared, and various factors influencing scar formation and collagen arrangement were analyzed. Results: Gel/Ad-RLX decreased scar size, color index, and pliability. Immunohistochemistry showed decreased levels of majorextracellular matrix proteins in the gel/Ad-RLX-treated group. Furthermore, treatment with gel/Ad-RLX reduced expression of tissueinhibitor of metalloproteinase-1 and alpha-smooth muscle actin and markedly increased expression of matrix metalloproteinase-1 in pig scar tissues. Gel/Ad-RLX also significantly downregulated TGF-β1 and upregulated TGF-β3 mRNAs in pig scar tissues. Conclusion: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeuticeffects on scar formation.