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- 저자 : 윤견일(K . I . Yoon) (검색결과 2 건)
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혈액투석중 혈청 지질과산화물 농도 변화와 내인성 항산화제 사이의 연관성
최규복(G . B . Choi),윤견일(K . I . Yoon) 대한내과학회 1997 대한내과학회지 Vol.53 No.5
N/A Objectives: Membrane bioincompatibility induce neutrophils to release of oxygen free radicals, resulting in cell membrane attack through peroxidation of polyunsaturated fatty acids. It was reported that serum antioxidant activity were significantly lower in CRF patients and the plasme lipid peroxide (LPO) level in the dialyzed patients was increased. So, we investigated whether or not the serum LPO level increases in chronic renal failure, and then investigated the relationship between the change of serum LPO level during hemodialysis and the endogenous serum antioxidants. Methods: The 20 healthy control with normsl renal function, 11 CRF patients and 34 ESRD patients maintained on hemodialysis were studied. We measured serum LPO by using thiobarbituric acid test reaction. Among endogenous antioxidants, serum ceruloplasmin, transferrin and vitamin C were measured. Serum LPO level were measured just before and after hemodialysis. Serum ceruloplasmin, transferrin, and vitamin C were measured just before initiation of hemodialysis. Results: Serum LPO levels obtained from CRF patients(12.6±8.3nM/mL) were significantly higher than from healthy control(4.3±0.9nM/mL) and than from HD patients(6.9±3.8nM/mL). But there were no significant difference between healthy control and HD patients. We found that significant amount of LPO were eliminated through dialyzer during hemodialysis. In 11 patients, serum LPO level increased significantly from a basal level of 5.0±2.0nM/rnL to a 6.1±2.4nM/mL after hemodialysis, but in 23 patients decreased significantly from a 7.9±4.lnM/ mL to a 5.9±2.4 nM/mL. Among 5 patients with low serum ceruloplasmin level(<25mg/dL), serum LPO level increased after hemodialysis in 4 patients. In contrast, among 29 patients with normal or high serum ceruloplasmin level(>25mg/dL), serum LPO level decreased after hemodialysis in 22 patients. So, the change of serum LPO level during hemodialysis was related to the serum ceruloplasmin level. But the change was not related to the serum transferrin or vitamin C level. Conclusion: In CRF patients, the serum LPO level may be increased by decreased urinary elimination or by oxidation injury. Hemodialysis may lower the serum LPO level by clearance through dialyzer or by improvement of antioxidant activity. And endogenous antioxidant like ceruloplasmin may play a important role in the protection from oxidation injury and decreased antioxidant activity may be one of the causes of pathological process induced by membrane bioincompatibility.
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본태성 고혈압 환자에서 죽상경화증과 Endothelin 사이의 상관성
홍미재(M . J . Hong),최규복(G . B . Choi),윤견일(K . I . Yoon),최혜영(H . Y . Choi) 대한내과학회 1996 대한내과학회지 Vol.51 No.6
N/A Objectives: In recent years there has been several reports that plasma endothelin concentration is elevated in hypertension. But there is debate on the role of the endothelin in hypertension. So, we investigate the relationship between atherosclerosis and endothelin in hypertension Mothods: We measured carotid intima-media thickness by a B-mode ultrasonic system, serum lipoprotein(a) by ELISA, and plasma endothelin by RIA. 26 patients with essential hypertension(male 8, female 18) were studied. We measured the maximum intima plus media thickness. We regarded the morphologic changes as positive sonographic finding if there was atheroma or intima-media thickness was greater than 1.3 mm, Results: There was significant correlation between plasma endothelin concentration and serum lipoprotein(a) level(r=0,57, p<0.05). In 8 patients with elevated serum lipoprotein(a) level(>20 mg/dL), plasma endothelin concentration were significantly higher than in 18 patients with normal serum lipoprotein(a) level(3.1±1.44 vs 2.4±0.68, p<0.05, 1-tail prob). But no significant difference in carotid intima-media thickness was found between the above two groups. And there were no significant differences in plasma endothelin concentration or serum lipoprotein(a) level between patients with positive and those with negative sonographic finding. Conclusion: These results suggest that the elevated plasma level of endothelin in patients with essential hypertension may bo related to endothelial damage such as atherosclerosis. But it is hardly to say that the morphologic changes on sonography may reflect exactly the local damage of endothelium.
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