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柳浩仁,徐成勳,金壽億 慶熙大學校 1989 論文集 Vol.18 No.-
To Increase the solubility of minoxydil which is used as an antihypertensive agent, its inclusion complex was prepared and studied in this paper. Inclusion complexes of minoxydil with β-cyclodextrin were prepared by three different methods; Coprecipitation method, kneading method and freezedrying method. Inclusion complex formation of minoxydil with β-cyclodextrin was ascertained by powder x-ray diffractometry, differential scanning calorimetry and IR spectroscopy. Inclusion complex of minoxydil with β-cyclodextrin in 1:3 molar ratio seemed to be suitable for the preparation of complex with higher purity, and its dissolution behavior in water was compared with that of intact minoxydil and physical mixture of minoxydil with β-cyclodextrin. The dissolution rate of minoxydil in water was found to be markedly increased by β-cyclodextrin complexation.