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      • KCI등재

        증례 : 수년에 걸쳐 진행한 폐결절을 가진 불명열 환자에서의 항암화학요법 1예

        김유정 ( Yu Jung Kim ),김선영 ( Sun Young Kim ),오명돈 ( Myoung Don Oh ),유철규 ( Chul Gyu Yoo ),허대석 ( Dae Seog Heo ),김철우 ( Chul Woo Kim ),방영주 ( Yung Jue Bang ) 대한내과학회 2006 대한내과학회지 Vol.71 No.4

        저자들은 수년에 걸쳐 진행한 폐결절을 가진 불명열 환자에서 조직학적으로 규명되지는 않았으나 EB 바이러스 관련 림프세포증식질환을 의심하여 항암화학요법을 시행한 후 관해를 이룬 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Classic causes of fever of unknown origin (FUO) are infections, neoplasms, collagen vascular diseases and drugs. However, large studies of FUO have consistently reported that a considerable proportion of patients with FUO remain undiagnosed. We report a patient with a prolonged course of FUO and progressive pulmonary nodules in whom extensive clinical and laboratory evaluation did not reveal specific diagnosis. The patient had recurrent episodes of fever for more than three years, and the pulmonary nodules gradually progressed in size and number despite administration of antibiotics including antifungal and antituberculosis agents. Several pathologic examinations demonstrated an organizing pneumonia or non-neoplastic lung parenchyma with lymphoplasmacytic infiltration only. After a protracted course of disease, we thought that this patient might have lymphoproliferative disorder, possibly EBV-associated, and started anti-cancer chemotherapy. He was successfully treated with eight cycles of chemotherapy including cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP).(Korean J Med 71:442-448, 2006)

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        방사선 폐렴의 임상적 특징

        이재호(Jae Ho Lee),현인규(In Gyu Hyun),최동철(Dong Chul Choi),유철규(Chul Gyu Yu),송재훈(Jae Hoon Song),정기석(Ki Suck Jung),김영환(Young Whan Kim),한성구(Sung Ku Han),심영수(Young Soo Shim),김건열(Keun Yeol Kim),한용철(Yong Chul Han 대한내과학회 1991 대한내과학회지 Vol.40 No.3

        N/A Radiation pneumonitis is one of the most important early complication of radiation therapy. In order to examine whether or not the increasing in patients suffering from concurrent COPD and Lung Ca, and to study clinical features of radiation pneumonitis, the writers conducted a retrospective study on 60 patients with proven lung cancer who underwent radiation therapy during the period from 1985 to 1988 and had their PFT performed before the radiation and obtained the following results; 1) Non productive cough was the most frequent clinical symptom of radiation pneumonitis and dyspnea, whitish sputum, chest tightness, mild fever was also present. The clinical symptom was not related to radiation dose, initial time of pneumonitis, PFT, age but was more serious in the patients with FEV1/FVC more than 70%. 2) Radiation pneumonitis occurred most frequently between the period of 4 weeks and 12 weeks and onset time of radiation pneumonitis was not related to the radiation dose, PFT, age, 3) Chest X-ray showed alveolar, alveolar-interstitial mixed, interstitial pattern, fibrosis confined to radiation field and changed with time. 4) There was no significant difference between FEV1, FVC, FEV1/FVC and incidence of radiation pneumonitis but in patents with FEV1/FVC more then 70%, there was significantly higher incidence of radiation pneumonitis. 5) The incidence of radiation pneumonitis was increased as radiation dose was increased.

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