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초미분말 고로슬래그를 혼합한 시멘트 페이스트의 유동특성
유창달,변승호,송종택 한국세라믹학회 2007 한국세라믹학회지 Vol.44 No.8
Rheological properties of cement paste containing ultrafine blastfurnace slag (UBS, 9600 cm2/g) were investigated by mini-slumptest, pH meter, conduction calorimeter and coaxial cylinder viscometer. In order to improve rheological properties of the cement paste,granulated blastfurnace slag (GBS, 3500 cm2/g) and polycarboxylate type superplasticizer (PC) were also used in this experiment. Thefluidity of cement paste containing UBS was decreased. The yield stress and plastic viscosity of cement paste was increased withincreasing UBS. But the rheological properties were improved when GBS and PC were added to UBS blended cement paste. In therelationship between the yield stress and the plastic viscosity or the mini-slump value, the yield stress of the cement paste wasproportional to the plastic viscosity of it. However the cement paste mini-slump value was in inverse proportional to the yield stres.
전신성 홍반성 루푸스 환자에서 자가항체 검출을 위한 이중면역확산법, ELISA, Western Blot법의 비교 및 자가항체와 임상양상의 연관에 관한 연구
유창달 ( Chang Dal Yoo ),차훈석 ( Hoon Seok Cha ),김성욱 ( Seong Wook Kang ),이은봉 ( Eun Bong Lee ),백한주 ( Han Joo Baek ),임용성 ( Yong Seong Im ),김현아 ( Hyun A Kim ),신찬수 ( Chan Su Shin ),송영욱 ( Yeong Wook Song ),최강원 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.2
Objective: To investigate the autoantibody profile and its clinical association in patients with systemic lupus erythematosus. Methods: The frequency and clinical correlation of autoantibodies were studied in 73 patients with systemic lupus erythematosus who have been followed in Seoul National University Hospital. Double immunodiffusion, ELISA and immunoblot were used for the detection of autoantibodies. Results: The frequency of each autoantibody measured by double immunodiffusion was as follows; anti-Ro 53.4%, anti-La 11.0%, anti-Sm 20.5%, anti-U1 RNP 20.5%. The frequency of each autoantibody by ELISA was as follows; anti-Ro 69.9%, anti-La 27.4%, anti-Sm 54.8%, anti-Ul RNP 68.5%, anti-dsDNA 72.6%, anti-cardiolipin 47.2% (IgG 43.1%, igM 15.3%). The frequency of each autoantibody by immunoblot was as follows; anti-Ro 15.1%, anti-La 42.5%, anti-Sm 46.6%, anti-Ul RNP 42.5%. anti-ribosomal P(P0) 27.4%. Anti-Ro was associated with decreased frequency of nephrotic syndrome. Anti-Ul RNP was associated with increased frequency of malar rash, Raynaud phenomenon and decreased frequency of nephritis. Patients with both anti-Ro and anti-La had more frequent serositis than those with anti-Ro only. Patients with both anti-Sm and anti-Ul RNP had less frequent thrombocytopenia than those with anti-Ul RNP only. And patients with anti-Sm and anti-dsDNA had more frequent arthritis than those with only one of both antibodies. There was a positive correlation of autoantibody titers between anti-Ro and anti-La, anti-Sm and anti-Ul RNP, anti-dsDNA and anti-cardiolipin (IgG). Taking the result of immunoblot as a standard, both of double immunodiffusion and ELISA showed low sensitivity but high specficity for anti La. As for anti-Sm and anti-Ul RNP, double immunodiffusion showed low sensitivity but high specificity, whereas ELISA showed high sensitivity but low specificity. Conclusions: In our study, some autoantibodies (anti-Ro, anti-Ul RNP) were associated with certain clinical manifestations while others not. Immunoblot being used as a standard method, ELISA showed higher sensitivity but lower specificity for anti-La, anti-Sm and anti-Ul RNP compared with immunodiffusion. It is recommended that in interpretating the laboratory findings of these autoantibodies these parameters of each method should be considered.
고로슬래그 분말도가 시멘트 페이스트의 유동특성에 미치는 영향
송종택,유창달,변승호 한국세라믹학회 2007 한국세라믹학회지 Vol.44 No.2
In this study, the rheological properties of cement pastes containing blastfurnace slag of different fineness were investigated. The fluidity of cement pastes with low Blaine value blastfurnace slag was increased with decreasing the plastic viscosity and the yield stress of pastes. And the optimum dosage of polycarboxylate type superplasticizer to the cement pastes was confirmed according to the fineness and the replacement ratio of blastfurnace slag. All cement pastes showed the thixotropy behavior. And also it was formed that the segregation range of cement pastes was occurred below 10 D/cm2 of the yield stress and below 350 cPs of the plastic viscosity by the coaxial cylinder viscometer.
최경호,이은봉,유창달,백한주,광성욱,신기철,이연정,김현아,전주홍,김채완,신동명,김인규,송영욱 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.6
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrul-line residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of anti-filaggrin antibodies recognizing uncitrullinated filaggrin in rheumatoid arthritis, we assayed anti-body titers using unmodified recombinant filaggrin in the sera from 73 patients with rheumatoid arthritis, 150 patients with other connective tissue diseases and 70 normal controls. We also performed the correlation analysis between antibody titers and the clinical variables in patients with rheumatoid arthri-tis. Titers of IgG anti-filaggrin antibodies were signi-ficantly higher in rheumatoid arthritis patients compared to normal controls (P = 0.02), but not in patients with osteoarthritis, ankylosing spondylitis or systemic lupus erythematosus. IgG anti-filaggrin antibodies were more frequently found in patients with rheumatoid arthritis compared to normal controls (12.3% vs 1.4% respectively, P = 0.04). Ananti-filaggrin antibody titer was correlated with visual analogue scale of pain, tender joint count, Ritchie articular index or C-reactive protein, but not with anti-nuclear antibody or rheumatoid factor. These results suggest that anti-filaggrin antibody recog -nizes the uncitrullinated filaggrin as an antigen and its titer correlates with clinical parameters, explain-ing the variable sensitivity of anti-filaggrin antibody test.
후천성 면역부전증에 병발한 원발성 중추신경계 림프종 1예
이은봉,유경훈,유창달,김남중,오명돈,신형식,백한주,지제근,허대석,최강원 대한감염학회 1996 감염 Vol.28 No.4
저자들은 인간면역부전바이러스 검사 양성, cryptosporidiosis로 후천성면역부전증을 진단받은 환자에서 나타난 원발성 중추신경계 림프종을 경험하였기에 이를 보고한다. A 43-year old man with acquired immunodeficiency syndrome was admitted to this hospital because of cognition defect. The patient with a history of homosexual behaviour developed acquired immunodeficiency syndrome seven months before this admission, when he was positive for HIV test, had cryptosporidiosis and suspicious pulmonary tuberculosis. One week before admission, fever, cognition defect, including inappropriate response and memory disturbance, and ptosis of the left eye developed. Brain MRI showed an ill-defined, rim enhancing lesion in the left mid brain and both thalami. Stereotaxic brain biopsy showed malignant lymphoma with monoclonal T cell phenotype on nested PCR and immunohistochemistry. Brain radiotherapy of 6120 rad was delivered, which resulted in stable disease. We report the first case with acquired immunodeficiency syndrome and primary central nervous system lymphoma in Korea.
내과 영역 세균 감염증 환자에 대한 Flomoxef의 효과 및 안전성에 관한 제 3상 임상 시험 : Phase Ⅲ clinical trail
김성민,김남중,유창달,백한주,이은봉,오명동,최강원 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.2
새로운 oxacephem계 항생제인 flomoxef의 효과 및 안전성을 ceflotaxim과 비교 평가하기 위해 서울대학교 병원 내과에 입원한 세균 감염증 환자를 대상으로 제3상 임상 시험을 실시하였다. 대상 환자는 flomoxef군 25명과 cefotaxime군 25명이였으며, 이 두 군사이에 연령, 기저 질환, 감염증의 종류 및 원인균에 있어서 유의한 차이는 없었다. Flomoxef군과 cefotaxime군의 감염증은 각각 균혈증 4,3; 원발성 복막염 6,9;요로 감염증 4,5;하부 호흡기 감염증 4,3; 피부 및 연조직 감염증 3,2;담도 감염증 2, 2였다. 임상적 치료 효과는 flomoxef군에서 86%(19/22), cefotaxime군에서 83%(19/23)으로 양군간에 유의한 차이는 없었다. 미생물학적 반응은 flomoxef군중 67%(4/6)에서, cefotaxime군에서 75%(3/4)에서 균제거 효과가 있었다. 부작용으로 flomoxef군에서 간효소치의 상승이 2예 관찰되었으나, 일시적이고 경미하여 투약을 중단할 정도는 아니였으며, cefotaxime군에서 피부발진 1예가 관찰되었다. 결론으로 flomoxef는 세균 감염증을 치료하는데 안전하고 효과적인 항생제로 생각된다. To evaluate efficacy and safety of flomoxef, a new oxacephem antibiotics, apahase 3 clinical trial was done. Fifty patients with proven or presumptive bacterial infections were randomly assigned to either flomoxef or cefotaxime. Age and sex distributions, underlying diseases and type of infections were similar in two treatment groups. types of the infections of flomoxef group and cefotaxime group were bacteremia 4, 3; spontaneous bacterial peritonitis 6, 9; UTI 4, 5; pneumonia 4, 3; skin and soft tissue infections 3, 2; and cholangitis 2, 2, respectively. Clinical response rate was 86% in flomoxef group, and 83% in cefotaxime group. One patient from each group, who was infected with E.faecalis infection, did not respond to the treatment. Two of the flomoxef group had transient elevation of transaminase, and one of the cefotaxime group developed skin rash, which subsided 2 days after discontinuation of the drug. In conclusion, flomoxef may be safe and effective in the treatment of patients with bacterial infections.