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The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis
유일한,김명진,김지영,성정준,박성택,안석원 대한의학회 2019 Journal of Korean medical science Vol.34 No.28
Background: Multiple sclerosis (MS) is an immune-associated inflammatory disorder of the central nervous system and results in serious disability. Although many disease-modifying therapy drugs have been developed, these drugs have shown limited clinical efficacy and some adverse effects in previous studies, therefore, there has been reasonable need for less harmful and cost-effective therapeutics. Herein, we tested the anti-inflammatory effect of sulforaphane (SFN) in a mouse model of experimental autoimmune encephalomyelitis (EAE). Methods: The EAE mice were randomly assigned into two experimental groups: the phosphate-buffered saline (PBS)-treated EAE group and SFN-treated EAE group. After EAE mice induction by auto-immunization against the myelin oligodendrocyte glycoprotein peptide, we evaluated EAE symptom scores and biochemical analyses such as infiltration of inflammatory cells and demyelination of the spinal cord. Furthermore, western blotting was performed using the spinal cords of EAE mice. Results: In the behavioral study, the SFN-treated EAE mice showed favorable clinical scores compared with PBS-treated EAE mice at the 13th day (1.30 ± 0.15 vs. 1.90 ± 0.18; P = 0.043) and 14th day (1.80 ± 0.13 vs. 2.75 ± 0.17; P = 0.003). Additionally, the biochemical studies revealed that SFN treatment inhibited the inflammatory infiltration, demyelinating injury of the spinal cords, and the up-regulation of inducible nitric oxide synthase in the EAE mice. Conclusion: The SFN treatment showed anti-inflammatory and anti-oxidative effects in the EAE mice. Conclusively, this study suggests that SFN has neuroprotective effects via anti- inflammatory processing, so it could be a new therapeutic or nutritional supplement for MS.
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한 소규모 초등학교 초임교사의 교직사회화에 대한 자문화기술지
유일한,이동성 한국질적탐구학회 2019 질적탐구 Vol.5 No.3
The aim of this paper is to provide an internal overview on the coping strategies of a novice teacher for socialization in a small elementary school in rural area. This paper applied an autoethnography to accomplish this purpose, and three core categories and six subcategories were derived from thematic analysis, which is based on the pragmatic eclecticism. The results of this paper were as follows. Firstly, as a novice teacher in a small elementary school in rural area, the teacherinternalized a hierarchical power relationship among faculty members of teaching society and the recommendations of senior staff. Secondly, as a novice teacher in a small elementary school in rural area, the teacher performed role of an optimized “multi-player” and “general consultant” in relationships with students and parents. Thirdly, as a novice teacher and researcher in a small elementary school in rural area, the teacher learned the school curriculum through a self-sufficient strategy, and applied a differential teaching method, which is different from pedagogy in large scale school. The results of this study will be a guideline to support novice teachers’ adaptation and development in small elementary schools in rural area, and this paper will contribute to improve practical exercise programs for elementary pre-service teachers. 이 글의 목적은 한 농어촌지역 초임교사의 생존전략을 내부자적 관점에서 조명함으로써 소규 모 초등학교 교사의 교직사회화 과정을 조명하는 데 있다. 이 글은 자문화기술지에 기초하여 질 적 자료를 수집하였으며, 실용적 절충주의에 기초한 주제 분석을 통하여 범주(3개)와 하위범주 (6개)를 생성하였다. 첫째, 농어촌지역 소규모 초등학교 초임교사는 단위학교 교직원들 사이에 서 위계적 권력관계를 내면화하였다. 특히, 연구자로서의 나는 경력교사들과의 관계 측면에서 전략적으로 순응함으로써 점차적으로 교직사회에 적응하였다. 둘째, 초임교사이자 연구자로서 의 나는 학생 및 학부모들과의 관계형성과 관련하여 그들이 원하는 다중적인 역할을 수행함으 로써 농어촌지역 소규모 학교의 교직사회에 적응하였다. 셋째, 연구자로서의 나는 자기충족적 인 방식으로 학교의 교육과정을 운영하고, 다인수 교실환경을 전제로 한 기존의 정형화 된 교수 법으로부터 벗어남으로써 농어촌지역의 소규모 학급에 적합한 교육과정과 수업을 실현할 수 있 었다. 이 연구의 결과는 초등 교사 양성기관의 교육실습을 개선하고, 농어촌지역 소규모 초등학 교 초임교사의 적응과 전문성 발달을 도모하기 위한 기초자료로써 기여할 수 있을 것이다.
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Application of respiratory function tests in patients with neurological diseases
유일한,최석진,성정준 대한임상신경생리학회 2023 Annals of Clinical Neurophysiology Vol.25 No.1
Breathing is controlled by complex interactions between the central and peripheral nervous systems in conjunction with the respiratory system. Neurological diseases predispose patients to nocturnal desaturation and pneumonia due to respiratory dysfunction, which increases mortality, daytime sleepiness and fatigue, and reduces the quality of life. Respiratory function tests are required to identify respiratory function decline and to consider compensatory management. This review summarizes the characteristics of several respiratory function tests and their applications to neurological diseases.
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유일한,김경래,정영수,진상윤,김예상,Yu Il-Han,Kim Kyung-Rai,Jung Youngsoo,Chin Sangyoon,Kim Yea-Sang 한국건설관리학회 2004 건설관리 : 한국건설관리학회 학회지 Vol.5 No.5
성과측정시스템(PMS)은 경영성과의 평가, 인적자원관리, 전략적 성과창출의 중요한 도구로 사용된다. 1990년대 이전까지 대부분의 기업들은 재무 중심의 성과측정을 하였지만, 최근 들어 비재무적 요소를 함께 고려한 다양한 관점에서의 균형 있는 성과측정을 하고 있다. 그러나 건설산업에서는 현실성 있는 PMS를 갖추고 있지 못한 실정이며, 이로 인해 건설산업 참 여 주체들이 스스로의 성과를 측정하고 관리하는데 한계와 문제점을 나타내고 있다. 따라서 본 연구는 건설산업의 핵심 참여 주체인 발주자, 시공사, 설계자가 스스로의 성과수준을 상대적으로 파악하고 관리할 수 있으며, 산업적 차원에서 이를 진단하고 서로 공유할 수 있는 비교가능한 PMS의 개념과 framework을 제시하고자 하였다. 연구결과로는 균형성과표(BSC) 기반의 성과지표 체계 및 측정방법, 그리고 지속적인 연구의 방향이 함께 제시되었다. The performance measurement system of a company is an important tool to evaluate business result, to manage human resource and to achieve strategic management goals. Until 1990's, the performance in most of companies had been measured by financial perspectives. Recently non-financial perspectives with various and balanced view points are used. In the construction industry, the same situation is happened. However, effective tools are not developed yet. Therefore, this research proposes a framework of the comparable performance measurement in the construction industry. This framework is based on concept of the balanced scorecard(BSC) and prepared respectively for owner, contractor and architect/engineer Using this framework, it is possible to compare performance of a company with each other and to benchmark the best performance.
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Factors Associated with Favorable Outcome of Topiramate Migraine Prophylaxis in Pediatric Patients
유일한,김우중,김훈민,임병찬,황희,채종희,최지은,김기중 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.3
Background and Purpose There are few studies that have investigated predictive factors related to migraine prophylaxis of which produced inconsistent results. The aim of this study was to identify factors that can predict the treatment response to topiramate prophylaxis in pediatric patients with migraine. Methods One hundred and thirteen patients who were older than 7 years and received topiramate for at least 3 months were recruited from the Seoul National University Bundang Hospital outpatient clinic from 2005 to 2014. A positive response was defined as a reduction of more than 50% in the number of migraine episodes after topiramate treatment. Proposed predictive factors such as migraine characteristics including severity and frequency were assessed, as were other data on sex, disease duration, associated symptoms, family history, and impairment of daily activities. Results Seventy patients (61.9%) responded to prophylactic treatment with topiramate. Patients who experienced significant impairment in daily activities showed significant benefit from the treatment (p=0.004). Sex, the severity, frequency, and duration of migraine episodes, disease duration, treatment duration, age at onset, and associated symptoms were not significantly related to a response to topiramate treatment. Conclusions Migraine characteristics and associated symptoms were not significantly related to a response to topiramate treatment. However, patients with significant impairment in daily activities showed significant benefit from the treatment, and so prophylactic topiramate treatment should be strongly encouraged in this patient group.
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