뇌성마비의 기능성평가도구에 대한 고찰 -GMFCS, GMFM 과 PEDI 중심으로-

유선애 ( Sun Ae Lyu ),김보경 ( Bo Kyong Kim ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.1

Objectives: This study is to investigate the method for assesment of cerebral palsy(CP), especislly focusing on function assesment Methods: We searched the recent date of the publication and paper in Cerebral Palsy Results: Measuring the function of children with cerebral palsy is mobility, self-care and social ability. Early adequate evaluation of motor development and prognosis of degree of long-term motor disability is very important not only for parents, but also for correct management of goal oriented rehabilitation treatment and for planning of preventive measures. 1. Gross Motor Function Classification System(GMFCS) is valuable to prognostication about gross motor progress in children with CP, using longitudinal observation. 2. Gross Motor Function Measure(GMFM) is the instrument most commonly used to measure gross motor function in children with cerebral palsy (CP). 3. Pediatric Evaluation of Disability Inventory(PEDI) is one of the most commonly used assessments for children with a disability. Conclusions: The functional Assesment of children with CP are used GMFCS, GMFM and PEDI.

소아복통 환아에 대한 향사육군자탕 가미방의 임상적 효능에 관한 연구

정민정,유선애,이승연,Jeong, Min-Jeong,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.3

Objectives This study for evaluating the effects of HyangsayukgunjatangGamibang on childhood with abdominal pain. Methods This clinical study has been carried out with 38 children, who visited to the Department of Pediatrics, $\bigcirc\;\bigcirc$oriental medical center from January 2005 to August 2007, who had been treated for abdominal pain with herbal medicine (HyangsayukgunjatangGamibang). This study had done by chart-review or by telephone research. Results 1. After treating with HyangsayukgunjatangGamibang, 34 children's abdominal pain was improved. (63.2%) 2. After treating with HyangsayukgunjatangGamibang, 13 children eat more than before. 3. After treatment with HyangsayukgunjatangGamibang, children's symptoms-constipation, nausea, headache, anorexia were improved. Conclusions HyangsayukgunjatangGamibang is effective in childhood abdominal pain.

주의력 간섭검사와 허약아 증상에 관한 연구 - 스트룹 아동 색상-단어검사 중심으로-

곡수영,유선애,이승연,Gok, Su-Yeong,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives The purpose of this study is to find out the correlation between Stroop interference and the symptoms of weak children. Methods Questionnaire and performed Stroop interference test were done by 145 patients in OO Oriental Medical Hospital from May to October 2009. 120 patients who were considered as the weak children were divided into two groups: Stroop Interference T score above average group and below average group, and were surveyed again. Results 1. The study showed that age, the highest marked subject and behavior habits correlate to interference score and subjects characteristics. 2. Weak children groups had the highest tendency of having weak heart followed by weak lung spleen, liver, and kidney. Normally, a patient belonged to more than one of the weak children groups. 3. The study showed that a group of children who has weak heart and lung were related to interference score. The group which earned below average interference score had the highest frequency of being children with weak heart group. The group scored above average, however, had the highest chance of being children with weak lung group. 4. The study showed that interference score was related to four out of fifty questions about the weak children symptoms. Plus, related questions were all about the heart weak children symptoms. Conclusions In conclusion, there were significant correlation between interference score and the group consists of children who were weak: more specifically with children with weak heart.

뇌성마비의 조기치료에 관한 문헌적 고찰 - 최근 중의 잡지 중심으로 -

곡수영,이승연,유선애,Gok, Su-Yeong,Lee, Seung-Yeon,Lyu, Sun-Ae 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : This study has been carried out to look into the methods of early treatment of cerebral palsy and the treatment effect by ages. Methods : The fifteen theses dealing with treatment effects by ages were analyzed, which were selected from the 121 theses retrieved out of the wu-ruan(五軟), wu-chi(五遲), wu-ying(五硬), naotan(腦?), naoxing-tanhuan(腦性??), during the period between the January 2004 to August 2008 by using the China Academic Journal(CAJ) of China National Knowledge Infrastructure(CNKI). Results : 1. Among the study objects in the 15 theses, it was identified that there were 1.97 times more boys with cerebral palsy than that of girls, and it appeared that there was no significant relationship between gender and the treatment. 2. The early treatment referred to the treatment which was carried out based on the early diagnosis within 6 months to one year after the birth. This is the time when the adaptability and plasticity of the brain are high, and it was found out that the treatment effective as babies are young. 3. For the treatment of cerebral palsy, the combination of Traditional Chinese and Western Medicine Therapy was more frequently used than the exclusive Chinese medical treatment method, and it was more effective. Especially in the case, the Chinese medical treatment was focused on the acupuncture and the Tuina Massage. Conclusions : 1. For the treatment of cerebral palsy, when the age between one and two years old was established as the standard. The younger the babies were, the higher treatment effects were obtained. 2. It appeared that the early treatment of oriental medicine had relatively excellent effects on cerebral palsy, but it turned out that we needed more studies for accurate results.

The Anti-allergy Effects of Injinho-tang on the RBL-2H3 cells

어경정,류지효,유선애,윤화정,고우신,Eo, Kyeong-Jeong,Lyu, Ji-Hyo,Lyu, Sun-Ae,Yoon, Hwa-Jung,Ko, Woo-Shin The Society of Korean Medicine Ophthalmology 2009 한방안이비인후피부과학회지 Vol.22 No.1

인진호탕(茵蔯蒿湯)은 한의학에서 여러 가지 질환에 사용되어 왔다. 특히 간경의 습열(濕熱)로 인한 질환에 습열을 제거함으로써 증(證)의 완화에 많은 응용이 되어 왔다. 본 연구는 습열(濕熱)로 인한 질환중의 하나인 아토피 피부염에 그동안 응용이 적은 인진호탕(茵蔯蒿湯)을 실험적으로 응용함으로써 임상적인 가치를 가질 수 있는 지에 대한 기초연구를 진행하였다. 본 실험에 사용된 세포주는 rat leukemia (RBL-2H3) cells로 인진호탕(茵蔯蒿湯)은 알레르기와 관련된 사이토카인인 tumor necrosis factor (TNF)-$\alpha$, interleukin (IL)-4를 용량의존적으로 억제하였지만 세포독성은 일으키지 않았다. 그리고 동물실험에서 인진호탕(茵蔯蒿湯)은 PCA반응에서 충분한 억제효과를 나타내었다. 또한 Compound 48/80으로 유도된 anaphylaxis shock도 용량 의존적으로 억제함이 밝혀졌다.

The Anti-allergic Effects of Dictamni Radicis Cortex(白鮮皮) on the PMA plus A23187-stimulated RBL-2H3 Cells

강호건,류지효,유선애,강경화,윤화정,김영희,김기영,이승연,고우신,Kang, Ho-Gun,Lyu, Ji-Hyo,Lyu, Sun-Ae,Kang, Kyung-Hwa,Yoon, Hwa-Jung,Kim, Young-Hee,Kim, Gi-Young,Lee, Seung-Yeon,Ko, Woo-Shin The Society of Korean Medicine Ophthalmology 2007 한방안이비인후피부과학회지 Vol.20 No.1

RBL-2H3 cell line을 이용하여 백선피의 항알레르기 효과를 알아보기 위하여 PMA와 A23187로 자극한 후 RBL-2H3 내의 과립에 Histamine와 같이 존재하는 ${\beta}-hexosaminidase$의 유출량의 억제 정도 및 합성된 후 분비되는 $TNF-{\alpha}$, IL-4의 합성조절 정도를 살펴본 결과, 백선피는 세포생존율에는 영향을 미치지 않고 백선피의 농도가 증가함에 따라 ${\beta}-hexosaminidase$의 세포 위로의 유출을 억제하였으며, 또한 알레르기 반응과 밀접한 관련이 있는 사이토 카인 중에 하나인 $TNF-{\alpha}$, IL-4의 mRNA 수준에서의 발현의 조절을 통한 합성도 감소하였다. 이 결과로 보아 백선피는 알레르기와 관련된 질환에 응용이 가능할 것으로 사료된다.

폐계허약아(肺系虛弱兒)에 대한 가감보폐양영전(加減保肺養營煎)의 임상적 효능 연구

곡수영,정선경,유선애,이승연,Gok, Su-Yeong,Jung, Sun-Kyung,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.2

Objectives The purpose of this study is to evaluate the clinical effectiveness and prophylactic treatment effectiveness of Gagam-Bopyeyangyeongjeon(GGBYJ) on the Lung Weakness Children(肺系虛弱兒) who catch cold easily. Methods The study has been carried out from 27 children, who were treated with GGBYJ in Department of Pediatrics, $\bigcirc\bigcirc$ Oriental Medical Hospital from August to December in 2009. The study was completed through patient chart review and telephone survey. Results 1. Immediately after the treatment, there was significantly decreasing(p=0.005) on respiratory symptoms in the Lung Weakness Children(肺系虛弱兒) who catch cold easily. 2. After the treatment, when season changes (three months later), there were preventive and continuous effects on reducing morbidity and on decreasing degree of symptoms against new respiratory infections compared to the previous year before taking medicine. 3. GGBYJ improved the respiratory symptoms, and also anorexia, constipation, heights, skin and fatigue. Conclusions In conclusion, there were significant clinical and preventive effectiveness of GGBYJ for the Lung Weakness Children(肺系虛弱兒) who caught a cold easily. Further studies are needed with more clinical cases.

승갈탕(升葛湯)의 제형변화에 따른 항알레르기 효과의 비교 연구

이승연,강경화,이해웅,유선애,김홍배,류지효,Lee, Seung-Yeon,Kang, Kyung-Hwa,Lee, Hai-Woong,Lyu, Sun-Ae,Kim, Hong-Bae,Lyu, Ji-Hyo 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1

Objectives Seunggal-tang is one of the prescriptions of oriental herbal medicine, which has been applied to several allergic diseases such as atopic dermatitis. This study was planned to compare differences of anti-allergic effects based on different form of Seunggal-tang by manufacturing differently. Methods Two types herb medicine products were used; aqueous extract (SG-T, Seunggal-Tang) and powder (SG-S, Seunggal-San) which were made from the same mixed formula of Seunggal-tang. To investigate in vitro anti-allergic activities, rat basophilic leukemia (RBL-2H3) cells were treated with SG-T and SG-S for 1 hour, and then stimulated with the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. We examined the release of beta-hexosaminidase, as a marker of degranulation, and the releases of tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, as proinflammatory cytokines. Results SG-T and SG-S didn't have effects on cell viabilities in concentrations under 2㎎/㎖. In additionto that, SG-T more inhibited releasing ${\beta}$-hexosaminidase, TNF-${\alpha}$ and IL-4 than SG-S. Conclusions These results indicate that SG-T is more effective against mast cell-mediated allergic reactions than SG-S.

갈근추출액이 알레르기 염증반응에 미치는 영향

김홍배,강경화,황원덕,유선애,이승연,Kim, Hong-Bae,Kang, Kyung-Hwa,Hwang, Won-Deuk,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives To evaluate that Okwada affected which factors for treatment of lung fibrosis. Methods Bleomycin induced lung fibrosis model made in mice. After Okwada lyophilized, power sample obtained and melt in distilled water. Okwada solution administered mice through oral route on 21 days after bleomycin instillation and this procedure performed once a day for 7 days. We divided by three groups; normal (control), bleomycin induced lung fibrosis without treatment (experimental), bleomycin induced lung fibrosis with treatment (treatment). On six weeks after bleomycin instillation, mice sacrificed and removed lung. We performed Western blot analysis for TGF-beta, phosphodiesterase 5A, interleukin (4,5,13) and compared therapeutic effects of Okwada. Results On western blot analysis, all normal and experimental mice detected TGF-beta, phosphodiesterase 5A, interleukin 4,5,13. The amount of band of TGF-beta, phosphodiesterase 5A, interleukin 5 in experimental and treatment group was similar. However, interleukin 4,13 of treatment group decreased compared with experimental group. Conclusions Okwada would be effected the lung fibrosis through suppression of interleukin 4,13.

승갈탕(升葛湯)을 사용한 아토피 피부염 환자에 대한 임상시험

신상호,김자혜,김미보,윤화정,유선애,이승연,이미연,김규곤,고우신,Shin, Sang-Ho,Kim, Ja-Hye,Kim, Mi,Yoon, Hwa-Jung,Lyu, Sun-Ae,Lee, Seung-Yeon,Lee, Mi-Yeon,Kim, Kyu-Kon,Ko, Woo-Shin 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objective : The purpose of this clinical research was to investigate the effects of Seunggaltang on patients with atopic dermatitis. Methods : Thirteen patients were treated with Seunggaltang and ten patients were treated with placebo for 8 weeks. We observed skin humidity, skin sebum,, transepidermal water loss, skin melanin, skin erythema, total IgE class and number of allergen. And Clinic Index of Atopic Dermatitis(Extent, Intensity, Subjective symptoms, Total score) was used to evaluate the effects of Seunggaltang. Statistical analysis was performed by using paired sample T-test. Statistical significance was achieved if the probability was less than 5%(P<0.05). The result were as follows : 1. Statistically, Seunggaltang didn't showed significant effect on skin humidity, skin sebum, skin transepidermal water loss, skin melanin and skin erythema. 2. Statistically, Seunggaltang showed significant effect on Clinic Index of atopic dermatitis. 3. Statistically, Seunggaltang didn't showed significant effect on total IgE class and number of allergen. 4. Before and after treatment, the results of blood test and urinalysis were normal. Conclusion : We speculate that Seunggaltang has some therapeutic effects in mitigating the symptoms of atopic dermatitis.