약물요법/전립선비대의 약물요법

유구한,이선주 대한의사협회 2008 대한의사협회지 Vol.51 No.7

Benign prostate hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in men older than the middle age, and is a pathologic process that contributes to lower urinary tract symptoms in aging men. Despite the significantly different proportion of men with moderate to severe symptoms, a clear trend toward an increase in symptom scores with advancing age is noticeable. Complications of LUTS and BPH, such as urinary tract infections, bladder decompensation, bladder stones, hematuria, urinary incontinence, upper urinary tract deterioration with renal insufficiency, and others are in general rare in properly supervised patients. Medical therapies investigated for BPH include α- adrenergic blockers, 5α- reductase inhibitors, combination, aromatase inhibitors, and numerous plant extracts. Medical therapy is now the usual first- line management of uncomplicated BPH with either an α- adrenergic blocker or (if the prostate is large) a 5α- reductase inhibitor. Combination therapy with both an α- adrenergic blocker and a 5α- reductase inhibitor has been demonstrated to be the most effective means of preventing disease progression.

투석 환자에서 복강경 근치적 신적출술 및 신요관적출술

유구한,전승현,김태환,이형래 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.8

Association of IL10, IL10RA, and IL10RB Polymorphisms with Benign Prostate Hyperplasia in Korean Population

유구한,김수강,정주호,장성구 대한의학회 2011 Journal of Korean medical science Vol.26 No.5

Cytokines such as interleukin 10 (IL10) may play an important role in the process of inflammation. The aim of this study was to analyze the association between IL10, IL10RA and IL10RB single nucleotide polymorphisms (SNPs), and benign prostate hyperplasia (BPH)in Korean population. All patients with BPH were divided into two groups according to international porostate symptom score (IPSS), prostate specific antigen (PSA) level, Q_max,and prostate volume. We selected two IL10 SNPs (rs1518111 and rs1554286), three IL10RA SNPs (rs2256111, rs4252243, and rs2228054), and two IL10RB SNPs (rs999788 and rs2834167). Genotypes of seven SNPs were determined through direct sequencing. The G/G genotype of IL10RB polymorphism (rs2834167) was associated with a high PSA level compared with the A/G + A/A genotypes (P = 0.009). Of IL10 SNP, the A/A genotype of rs1518111 and T/T genotype of rs1554286 were associated with small prostate volume,respectively (P = 0.011, P = 0.014). Moreover, the T/T genotype of IL10RB polymorphism (rs999788) was associated with high prostatic volume compared with the T/C + C/C genotypes (P = 0.033). The linkage disequilibrium (LD) blocks were formed in IL10 and IL10RA. However, haplotypes in the LD block were not associated with BPH. It is concluded that there is a strong association between the IL10 and IL10RB SNPs, and BPH in Korean population.

Treatment of Infected Urachal Cysts

유구한,이성주,장성구 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.3

방광경부 현수술후 봉합사에 의해 발생된 재발성 방광결석

유구한,안규일,장성구 경희대학교 2006 慶熙醫學 Vol.22 No.1

Stress urinary incontinence is a common problem which can be corrected surgically. Burch colposuspension is one of successful operation performed for stress urinary incontinence. We report a patient who presented urgency, tenesmus, frequency, dysuria after Burch colposuspension. Any patients with unexplained lower urinary tract symptoms following Burch colposuspension must be evaluated radiologically and urologically to find iatrogenic bladder stone.

방광경부 현수술후 봉합사에 의해 발생된 재발성 방광결석

유구한,안규일,장성구 경희대학교 경희의료원 2006 慶熙醫學 Vol.22 No.1

Renal Function Outcomes in Patients Undergoing Open or Laparoscopic Radical Nephrectomy

유구한,이형래,장성구,전승현 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.6

Purpose: We compared renal function outcomes in patients undergoing open or laparoscopic radical nephrectomy. Materials and Methods: Seventy-one patients undergoing open or laparoscopic radical nephrectomy for kidney disease with a normal contralateral kidney were identified between January 2004 and December 2007. Renal function was calculated by using the Cockcroft-Gault formula. Serial renal functions were checked from the day before surgery to 1 year after surgery. Exclusion criteria were preexisting renal insufficiency, urinary stone disease, and pancreatic and liver disorders. Results: Forty-one and 30 patients were treated with open radical nephrectomy or laparoscopic radical nephrectomy, respectively. The operative time and urine output of patients who underwent open and laparoscopic radical nephrectomy were 211.7±5.8 and 330.8±15.6 and 196.4±19.6 and 130.7±12.1, respectively (p=0.001, p=0.013). The glomerular filtration rates of patients who underwent open or laparoscopic radical nephrectomy were insignificant from baseline to postoperative day 360 (p>0.05). Conclusions: No significant differences in renal function were detected in the groups of patients who underwent open or laparoscopic radical nephrectomy from baseline to long-term follow-up. Purpose: We compared renal function outcomes in patients undergoing open or laparoscopic radical nephrectomy. Materials and Methods: Seventy-one patients undergoing open or laparoscopic radical nephrectomy for kidney disease with a normal contralateral kidney were identified between January 2004 and December 2007. Renal function was calculated by using the Cockcroft-Gault formula. Serial renal functions were checked from the day before surgery to 1 year after surgery. Exclusion criteria were preexisting renal insufficiency, urinary stone disease, and pancreatic and liver disorders. Results: Forty-one and 30 patients were treated with open radical nephrectomy or laparoscopic radical nephrectomy, respectively. The operative time and urine output of patients who underwent open and laparoscopic radical nephrectomy were 211.7±5.8 and 330.8±15.6 and 196.4±19.6 and 130.7±12.1, respectively (p=0.001, p=0.013). The glomerular filtration rates of patients who underwent open or laparoscopic radical nephrectomy were insignificant from baseline to postoperative day 360 (p>0.05). Conclusions: No significant differences in renal function were detected in the groups of patients who underwent open or laparoscopic radical nephrectomy from baseline to long-term follow-up.

전립선암 진단을 위한 경직장초음파검사에서 저반향병소와 혈류증가의 의의

유구한,전승현,임주원,장성구 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.2

Experimental Animal Models of Neurogenic Bladder Dysfunction

유구한,이선주 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.1

Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson’s disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha- blockers. In the development of a new medication, it is necessary to test the medication’s efficacy and toxicity by using a laboratory animal. The proper laboratory animal should have several characteristics. These are biological similarity to humans, a short generation period, and an environment that is easy to control. We describe the development of laboratory animals for the study of neurogenic bladder by decerebration, stroke, and spinal cord injury.

QR코드 교육계획안 활용이 유치원 학부모의 수업활동만족도에 미치는 영향

유구종(Ku Jong Yoo),한명옥(Myoung Og Han),김명숙(Myeong Sook Kim),최승연(Seung Yeon Choi) 한국열린유아교육학회 2014 열린유아교육연구 Vol.19 No.2

본 연구는 학부모의 수업활동 이해를 돕는 구체적인 자료를 수록한 QR코드를 교육계획안에 기록하여 제작한 QR코드 교육계획안을 활용했을 때와 기존의 교육계획안을 각각 활용하였을 때 학부모의 수업활동만족도에 어떠한 차이가 있는지 알아보고자 하였다. 이를 위해 서울시에 위치한 A유치원 만 5세 연령 두 학급 학부모 40명(비교집단 20명, 실험집단 20명)을 대상으로 기존의 교육계획안에 대한 만족도 측정을 실시하고, 12주간 실험집단 학급을 대상으로 QR코드 교육계획안을 활용한 후 교육계획안에 대한 만족도 측정을 실시하여 측정치를 분석하였다. 그 결과 첫째, QR코드 교육계획안을 활용하였을 때 교육활동 전반에 관한 만족도, 유아의 발달 이해에 대한 만족도, 유치원과 가정간의 연계교육 수행, 유치원과 가정간의 의사소통, 유아교육관련 정보획득 등에 있어 유의미한 차이가 있는 것으로 나타났다. 둘째, QR코드 교육계획안을 활용하였을 때 학부모의 교사 전문성 인식에 있어서 유의미한 차이가 나타났으나 지속적 활용 인식에서는 유의미한 차이가 나타나지 않았다. 본 연구는 교사-학부모간 효율적 의사소통으로 유아의 교육·보육에 대한 정보를 공유하고 서로간의 피드백을 통하여 효과적인 상호작용을 기대할 뿐 아니라 유치원의 교육계획안 작성 및 활용의 발전 방향을 모색하는데 그 목적이 있다. This study compares the use of a previous teaching plan with that of a QR code teaching plan. A plan made by recording on the teaching plan the QR codes that contain detailed data intended to help parents understand a class activity. The study`s purpose is to examine how parents` class activity satisfaction differs. Also, with this, the study intends to allow teachers and parents to share information about their children`s education and nurturing, realize effective interaction among them through giving and receiving feedback, and find out a developmental direction to make and use a teaching plan for kindergarteners. The study selected 40 parents (20 for the control group and 20 for the experimental group) of two classes of 5-year-olds at A Kindergarten located in Seoul. The study measured satisfaction with the previous teaching plan and analyzed the values of satisfaction about the teaching plan after using (for 12 weeks) the QR code teaching plan for the experimental group. According to the results, first, there was significant difference when the QR code teaching plan was utilized regarding satisfaction with a general educational activity, satisfaction with understanding their children`s development, implementation of connected education between the kindergarten and the family, communication between the kindergarten and the family, or acquisition of information about their children`s education. Second, there was a significant difference, when the QR code teaching plan was used, in the recognition of parents on the teacher`s expertise; however, no significant difference was shown in recognition on continual utility.