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자근에 의한 백혈병 세포주인 L1210 세포의 세포사 유도
원경숙,김대근,오찬호,소준노,은재순 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
Cellular death by apoptosis is an active process, depending on gene transcription and protein synthesis. It was reported that nitric oxide can induce apoptosis in several cancer cell-lines. We studied effects of Lithospermum erythrorhizon Siebold et Zuccarinii (Boraginaceae) Radix water extract (LE) on induction of transplanted-L1210 cells apoptosis in mice. When LE (500 mg/kg) was administered orally once a day for 7 days after transplantation of L1210 cells to mice, DNA fragmentation of transplanted-L1210 cells was induced and mitochondrial transmembrance potential of those cells was reduced. Also, DNA fragmentation of L1210 cells was enhanced by co-culture with the peritoneal macrophages obtained from LE-administered mice and was partly inhibited by L-NMMA in vitro. LE enhanced the production of nitric oxide from peritoneal macrophages. These results suggest that administration of LE partly induces apoptosis of transplanted-L1210 cells in the early stage via stimulation of nitric oxide production from macrophages.
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원경숙 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.1
Since 1946, radioiodine (I-131) therapy has been one of the standard treatments for differentiated thyroid cancer (DTC). Recently the occurrence of thyroid cancer was markedly increasing and most of them were limited disease. Several reports said that there is no significant difference of outcome between low and high dose radioiodine therapy in patients with low to intermediate risk category of thyroid cancer. In this review, current effectiveness and toxicity of radioiodine ablation will be compared between low and high dose radioiodine in patient with low to intermediate risk DTC.
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원경숙,이태원,은재순,송정모 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
The specific immune response of unripened fruits and ripened fruits of Rubus coreanus Miquel was examined in BALB/C mice. The 70% ethyl alcohol extracts (20 or 100 ㎎/㎏) of unripened fruits (RCE-Ⅰ) and of ripened fruits (RCE-Ⅱ) were administered p.o. once a day for 7 days. RCE-Ⅰ and RCE-Ⅱ decreased the viability of thymocytes, but increased the viability of splenocytes. Also, RCE-Ⅰ enhanced the population of helper T and cytotoxic T cells in thymocytes and RCE-Ⅱ enhanced the population of helper T cells. Furthermore, RCE-Ⅰ and RCE-Ⅱ decreased the population of B220^+ cells and Thy1^+ cells and helper T cells in splenocytes. In a general way, the immunosuppressive action of RCE-Ⅰ was more potent than those of RCE-Ⅱ. These results suggest that RCE-Ⅰ and RCE-Ⅱ have a regulative action of immune response via decrease the viability of thymocytes and increase the viability of splenocytes.
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Recent Trends in Nuclear Cardiology Practice
원경숙,송봉일 전남대학교 의과학연구소 2013 전남의대학술지 Vol.49 No.2
Over the past three decades, radionuclide myocardial perfusion scintigraphy (MPS)has become established as the main functional cardiac imaging technique for ischemic heart disease. It is currently appropriate for all aspects of detecting and managing ischemic heart disease, including diagnosis, risk assessment and stratification, assessment of myocardial viability, and evaluation of left ventricular function. The purpose of this article was to review recent trends in nuclear cardiology practice, excluding positron emission tomography. The past few years have brought several rapid developments that have increased photon sensitivity in nuclear cardiology scanner hardware. Additionally, software applying new methods of single photon emission tomography (SPECT) reconstruction on conventional and dedicated systems has preserved or even improved SPECT image quality with lower count statistics. On the other hand, much interest has been shown in lowering the radiation dose by the stakeholders of MPS.
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T1-201 게이트 심근 SPECT에서 디피리다몰 부하로 유도된 일시적 좌심실 기능이상
원경숙 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.3
목적 : 이 연구의 목적은 TI-201 게이트 심근 SPECT시 나타나는 부하 후 일시적 좌심실 기능이상의 임상적 의미를 알아보고자 하는 것이다. 대상 및 방법 : 연구대상은 디피리다몰 부하 게이트 심근 SPECT를 시행한 환자 중 관상동맥조영술을 두 달 이내에 시행한 환자로 이 중 심근경색이 있는 경우는 제외하였다. 게이트 SPECT는 부하기와 재분포기 모두 실시하였으며 부하시 좌심실 구혈률이 재분포기에 비하여 11%이상 감소한 경우에 부하 후 심근 기질이 있다고 정의하였다. 총 93명의 대상환자를 관상동맥조영술 결과에 따라 정상(1군)과 관상동맥 질환(2군)의 두 군으로 나누어 부하 후 좌심실 기능이상의 빈도에 차이가 있는지 알아보았다. 결과 : 정상 대조군에서 좌심실 구혈률은 4시간 재분포기에 비하여 부하기에 평균 3.1% 증가하였으나, 관상동맥질환군에서는 평균 4.1% 감소하였다(p<0.01). 이완기말 좌심실 용적은 두 군 모두 부하기에 증가를 보였으며, 두 군 간에 유의한 차이가 없었다. 수축기말 좌심실 용적은 정상 대조군에서는 부하기에 0.7% 감소하였으나, 관상동맥질환군에서는 7.2% 증가하였다(p<0.01). 부하 후 좌심실 기능 이상은 1군 62명 중 0명, 2군 44명 중 8명(18.2%)으로 2군에서 유의하게 많았다(p<0.01). 정상 대조군에서 부하 후 일시적 좌심실 기능이상은 한 예도 관찰되지 않았다. 44명의 관상동맥질환 환자 중 8명에서 일시적 좌심실 기능이상이 관찰되었는데 단일혈과 협착에서 1 예(9.1%), 2 혈관 협착에서 0(0%), 3 혈관 협착에서 2 예(14.3%), 좌주간동맥협착에서 5 예(62.5%)였다. 관상동맥질환 환자군을 다시 단일과 두 혈관 협착군과 세 혈관협착과 좌주간동맥 협착군의 두 군으로 나누어 일시적 좌심실기능이상의 빈도를 비교하였을 때 4.5%와 31.8%로 유의한 차이를 보였다)p<0.05). 결론 : 디피리다몰과 TI-201을 이용한 게이트 심근 SPECT에서 심근경색을 제외한 관상동맥질환이 있는 경우 약 20%에서 부하 후 심근기절이 나타남을 알 수 있었으며, 하나 또는 두 혈관질환보다는 세 혈관 질환 또는 좌주간지 협착에서 더 많이 발생하는 경향이 있어 관상동맥질환의 중증도 계층화와 예후추정에 대한 부가적인 정보를 제공할 수 있을 것으로 보인다. Purpose : Recently the occurrence of dipyridamole stress-induced short term stunning was proven and it is reported that Bland Altman analysis by repeated acquisition TI-201 gated myocardial SPECT (gSPECT) revealed the 95% limit of agreement for LVEF was 10.3 %. The purpose of this study was to investigate the clinical value of dipyridamole induced transient LV dysfunction on TI-201 gSPECT. Materials and Methods : Total 93 patients were included and coronary angiography was performed in all patients less than 2 month from gSPECT. The patients with myocardial infarction were excluded. All patients underwent both dipyridamole stress and 4-h redistribution TI-201 gSPECT. Forty nine patients of total 93 showed normal coronary arteries (Group 1) and the remaining 44 patients had coronary artery disease (Group 2). We compared LV EF, EDV and ESV during post-stress and 4-h redistribution period calculated by gSPECT using quantitative gated SPECT software and the incidence of dipyridamole induced transient LV dysfunction between group 1 and 2. The criteria for transient LV dysfunction was defined more decrease ≥11% of LVEF during post-stress than 4-h redistribution according to previous reported Bland Altman analysis. Results: During post-stress and 4-h redistribution average of 3.1% increment in LVEF, 6.6% increment in LVEDV and 0.7% decrement in LVESV were shown after stress in Group 1, whereas 4.1% decrement, 9.7% increment and 7.2% increment in Group 2 respectively. Dipyridamole induced transient LV dysfunction was only detected in group 2 (18.2%) and not in group 1. It was more frequently observed in triple in triple vessel disease and left main disease (31.8%, N=22) than one and two vessel disease (4.5%, N=22). Conclusion: As with Tc-99m myocardial agent post-stress LV dysfunction was observed in dipyridamole TI-201 gSPECT. It was only detected in CAD and more frequently occurred in multivessel disease. Thus this finding seems to provide additional information in the diagnosis of coronary artery disease and prediction of prognosis.
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