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고혈압 환자에서 내피의존성 혈관반응에 대한 칼슘길항제와 비타민 C 의 효과에 대한 요구
온영근(Young Yeun On),최진호(Jin Ho Choi),채인호(In Ho Chae),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi) 대한내과학회 2001 대한내과학회지 Vol.61 No.5
N/A Background: The effect s of antihypertensive agents on endothelial function have not been fully evaluated in human hypertension and data on the forearm circulation of humans are controversial. The aim of this study was 1) to evaluate the endothelial function in hypertensive patients 2) to investigate whether vitamin C administration has any benefit on the endothelial function and 3) to determine whether treatment with calcium ant agonist improves endothelial dysfunction in hypertensive patients. Methods: The endothelial function was estimated using venous occlusion plethysmography (VOP) in 8 hyper tensive patients and 8 healthy volunteer s. The patients in the hypertension group were treated with amlodipine, then examined again. The change of forearm blood flow (FBF) was measured wit hacetylcholine infusion through brachial artery and also with intra-ar terial vitamin C. Results: Forearm blood flow response to acetylcholine was significantly enhanced with intra- arterial infusion of vitamin C in hypertensive group before antihypertensive treatment. Co- infusion of L- NMMA, an inhibit or of nitric oxide synthase, blunted forearm blood flow response toacetylcholine. After treatment with amlodipine for 2 months in hypertensive group, endothelium-dependent vasorelaxation to acetylcholine was significantly improved comparedt opretreatment, and vitamin C did not affect the improved endothelial function by amlodipine treatment. Conclusion: Vitamin C (acutely) and amlodipine (chronically) improved endothelial function inhypertensive patients. These results suggest that increased oxidative stress, at least in part , maybe involved in the decreased endothelial function in hypertension.(Korean J Med 61:518- 526, 2001)
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