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Polarity형성 T 세포와 Non-polarity T 세포에서 Microvilli 형성의 Small GTPase RhoA의 관련성
오지윤,서희주,이재설,김해영,문경미,최우봉,김병우,이종환 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4
The microvilli of circulating lymphocytes play an important role as specialized touching mediators including L-selectin and VLA-4 for transmigration of emigration from circulation to tissue during normal immunosurveillance and in response to inflammation. The microvilli change of circulatory T cells are controlled by the stimulation of chemokines or the interaction of other cells. In addition to this, T cell polarity is also important for cell biological function, effectively. Small GTPase RhoA controls cytoskeleton reorganization and ERM protein is a cross-linker between F-actin cytoskeleton and membrane proteins such as CD44, ICAM1-3. Above molecules is thought to be implicated to the control of cell polarity including microvilli formation. The present study was tried to understand some relation ship between polarity and microvilli. First of all, polarized T cells show that cell surface is smooth surface feature without microvilli, whereas non-polarized T cells display microvilli on the cell surface observed with SEM. Microvilli of non-polarized Jurkat T cell was disrupted in experiment to investigate the involvement of RhoA-ROCK signaling by using ROCK specific inhibitor, Y27632. Cells treated with bombesin, which is Rac1 activator, display surface feature without microvilli. When T cells touch BLDS that was derived from mouse lymph node microvilli was disappeared. In polarized EL4 T cells bearing over-expressing plasmid of PDZ domain constructed to increase active form of RhoA, polarity was disappeared, whereas microvilli was produced. Collectively, these data suggest that small GTPase RhoA and Rac1 is involved in microvilli formation. (Cancer Prev Res 15, 277-284, 2010)
전세가격의 비용화와 소비자물가지수: 소비자물가지수 자가주거비 반영을 중심으로
오지윤 한국개발연구원 2023 KDI Journal of Economic Policy (KDI JEP) Vol.45 No.4
The Chonsei component holds the highest level of weight (5.4%) in the composition of the Korean consumer price index (CPI). The variations in Chonsei prices are directly reflected in the CPI as a representation of cost swings. The Chonsei refers to a deposit that accumulates the costs related to housing services and is mostly affected by variations in rental rates. Nevertheless, it is important to note that Chonsei prices are also susceptible to fluctuations in interest rates, regardless of the rent prices. Therefore, if Chonsei were directly and one-to-one indexed to the CPI, they could include changes other than residential service prices. After analyzing the time series data of the Chonsei index and rent index inside the CPI, it becomes apparent that the Chonsei index displays an average annual growth rate of 2.3%, whilst the rent index reveals a growth rate of 0.9%. The observed disparity in growth rates indicates a divergence in trends between the two indices. It is posited that the Chonsei index, when capitalized, has had a more rapid increase compared to the rental index, owing to the gradual drop in interest rates. To effectively reflect fluctuations in the housing service costs, proxies for the Chonsei index were utilized in the construction of a consumer price index. The findings of our study suggest that, overall, the newly developed CPI demonstrates a comparatively lower rate of inflation when compared to the official CPI. Furthermore, the inclusion of imputed rents for owner-occupied housing in CPI amplifies this effect.
The Micro-Level Anatomy of Korea’s Rising Labor Share
오지윤 한국경제학회 2025 The Korean Economic Review Vol.41 No.1
This paper investigates the unique upward trend in the corporate labor share in South Korea since the 2000s, contrasting to the global decline observed during the same period. Analyzing financial statements from externally audited Korean firms, the study reveals that the increase in labor share is pervasive across all sectors, driven primarily by within-firm effects rather than the between-firm effects observed in the decline in the U.S. Notably, large firms have experienced a significant rise in labor share, attributed to the relatively slower growth in value-added compared to wages. The study also identifies a decreasing trend in industry concentration in South Korea, diverging from the increasing concentration and markups seen in the United States. These findings challenge the prevailing narrative attributing declining labor shares to technological advancements and the emergence of superstar firms, instead highlighting distinctive dynamics within the Korean corporate sector.
오지윤 한국응용경제학회 2020 응용경제 Vol.22 No.3
This study empirically estimates variety growth in Korea according to Bills and Klenow (2001). Using the Household Income and Expenditure Survey, the annual growth rate of tradable goods between 1990 and 2012 is 4.7 percent and 4.2 percent for non-tradable goods. When the period is divided into the first period (1991~2000) and the second half (2001~2012), the tradable goods grow 1.4% annually and 7.5% in the second half, accelerating the growth rate in the second half. On the other hand, non-tradable goods grow an average of 5.0 percent annually in the first half and 3.2 percent annually in the second half. 상품의 다양성 확대는 내생적 경제성장 이론에서 혁신의 지표로 간주되고, 경제성장과 밀접한 관련이 있는 것으로 알려져 있으나, 거시적 실증 연구는 제한적이다. 본 연구는 Bils and Klenow(2001)의 방법론을 주로 이용하여 수요측면에서 접근 가능한 자료를 이용하여 한국의 상품 다양성을 실증적으로 추정하였다. 가계동향조사 자료를 이용하여 수요측면에서의 상품 다양성을 측정한 결과, 1990년부터 2012년까지의 기간 중 교역재는 연평균 4.7%, 비교역재는 연평균 4.2% 성장한 것으로 나타났다. 전체 기간을 1991년부터 2000년, 그리고 2001년부터 2012년까지 나누어 보면, 교역재는 전반기 연평균 1.4%, 후반기에는 7.5%로 성장하여 후반기에 큰 폭으로 증가한 것으로 나타난다. 서비스재 중심의 비교역재는 전반기 연평균 5.5%, 후반기 3.2% 성장하여 오히려 후반기에 다양성의 성장이 감소한 것으로 나타났다.
오지윤,홍선호,이삭,전재호 서울교육대학교 초등교육연구원 2022 한국초등교육 Vol.33 No.2
This study examines the educational role of AI PengTalk, an English-speaking system powered by artificial intelligence (AI) technology, and proposes strategies for its use in elementary English education. A questionnaire was administered to examine the perceptions of AI PengTalk users (students, teachers, and parents), and the data were analyzed both quantitatively and qualitatively. The findings are as follows. First, students and teachers had more favorable perceptions of AI PengTalk than parents. Second, when teachers used AI PengTalk, they encouraged students to engage in more active use of it, attempted to scaffold the students’ learning, and designed lessons that seamlessly utilized the application. Third, regarding user preferences for the activities offered within the application, both students and teachers reported that they frequently used the “Topic World” and “Speaking” activities but rarely used the “Scan It” or “School Talk” activities. Lastly, with regard to suggestions for improving the application, the student comments focused on enhancing voice recognition capabilities and developing additional activities. The teacher comments, on the other hand, were more related with the application’s user interface and user experience. The researchers draws conclusions and makes several recommendations in light of these findings. 본 연구는 인공지능기술 기반 영어 말하기 연습 시스템인 EBS AI펭톡의 초등영어교육에서의 역할및 활용 방안을 탐색하는데 그 목적이 있다. 이를 위해 AI펭톡 활용에 관한 사용자의 인식 조사를 목적으로 AI펭톡 활용에 대한 전반적인 인식 및 만족도를 비롯하여 여섯 가지 항목으로 문항에 따라 리커트 6점 척도, 복수 문항 선택형, 주관식 단답형으로 설문지를 제작하였다. 교사, 학생, 학부모의 집단별특성에 따라 서로 다른 설문 문항을 구성하였으며, EBSe 웹사이트에 설문지를 게시하여 전국의 AI펭톡 사용자들이 자발적으로 온라인 설문에 참여하는 방식으로 진행되었다. 설문조사에 응답한 학생, 학부모, 교사의 응답 결과를 바탕으로 크게 AI펭톡에 대한 역할 인식, AI펭톡의 활용 현황, AI펭톡 개선요구 분석 및 활용 증대 방안을 제시하였다. 연구 결과 첫째, AI펭톡에 대한 역할 인식을 조사한 결과교사는 AI펭톡을 학습 상태 점검 도구 및 대화상대자로 인식한 반면, 학생과 학부모는 학습도우미와동기유발 도구로 인식하는 경향이 나타났다. 둘째, AI펭톡의 활용 현황을 분석한 결과, 교사는 자기주도학습 측면에서 더 높은 활용도를 보였다. 정규 수업에서 AI펭톡을 활용하는 경우에는 한 단원에 한차시를 활용하는 빈도수가 가장 높았으며, 주로 연습 활동과 마무리 활동에서 가장 많이 활용된다는 것으로 나타났다. 한편, 학생과 교사가 가장 많이 활용하는 학습영역을 비교하고 분석한 결과 두 집단 모두 토픽월드와 스피킹을 집중적으로 활용하였으며, 렛츠톡과 스캔잇은 교사가 사용을 주도하기보다는학생이 스스로 사용하는 것으로 나타났다. 셋째, AI펭톡의 개선 방안에 대해 분석한 결과 학생들은 음성인식 개선, 재미있는 활동(게임)추가, 참치캔을 활용한 다양한 활동 기능 추가, 매주 기록이 초기화되지 않도록 개선 등의 의견을 제시하였다. 교사들은 단원별 학습 콘텐츠를 쉽게 찾을 수 있도록 앱을 구성할 필요성, 학생들의 사용 기록을 종합적으로 보기 쉽게 나타내는 것이 필요하다는 의견을 제시하였다. 마지막으로 학부모의 접근성을 확대하기 위한 방안에 대한 언급을 한 것으로 분석되었다. 한편, AI 펭톡을 사용하지 않는 교사들은 교실내 학생 수준 차로 인한 활용의 어려움, 기자재 환경의 열악함, 교실 수업보다는 가정학습에 효과적이라는 의견 등을 제시하였다. 이와 같은 본 연구 결과는 EBS가 AI펭톡의 내용과 운영 구성을 보다 효과적이고 효율적으로 개선하고, 이를 기반으로 초등영어교육 현장에서 훨씬 더 유용하게 활용하고, 더 많이 사용할 수 있도록 하는 데 도움을 줄 것으로 본다.
오지윤,최유나,조수정,정찬영,조현석,이승덕,김갑성,김은정 대한침구의학회 2015 대한침구의학회지 Vol.32 No.4
Objectives: The Oriental medical device industry is expected to continue to experience signif- icant growth. It should increase its global market share rather than focusing on the domestic market. Countries around the world self-regulate their domestic market, so this study aims to aid in the development of a particular overseas market by introducing the U.S.(the largest market) medical device registration and approval process. Methods: For an understanding of the US medical device licensing process, we researched the relevant regulatory organization (FDA), the history, definition and classification of medical de- vices, the approval and 510(k) submission process related to substantial equivalence, IEC 60601-1 Edition 3, usability tests, and so on. Results: Medical devices in the United States are assigned to one of three regulatory classes: Class I, Class II and Class III, based on the level of control necessary to assure the safety and effectiveness of the device. If a company's device is classified as Class II and if it is not exempt, a 510k will be required for marketing. 1) A 510(k) is a premarket submission made to the FDA to demonstrate that the new device to be marketed is“substantially equivalent”to a legally marketed device (predicate device) 2) The IEC 60601-1 Edition 3 preparation process, which contains information related to us- ability, is expensive and time-consuming but a critical requirement. Conclusions: Although the U.S. market has high barriers to entry, access to this, large overseas market will encourage development of the Oriental medical device industry and commercial value enhancement is expected.
오지윤 한국응용경제학회 2024 응용경제 Vol.26 No.2
우리나라에서는 전세가 주요 임대 계약 형태로 자리 잡고 있어, 순수 임대료 추이를 직접 관찰하기 어렵다. 본 연구에서는 임대 실거래 정보를 포괄하여 월세 상당액을 반영한 통합주거비지수를 산출하고, 이 지수가 전세 지수 대비 차별적인 정보를 제공하는지 살펴보았다. 2011년부터 2023년까지 통합주거비와 전세 지수를 비교한 결과, 임대료 변화를 나타내는 통합주거비 지수는 전세 지수와 다른 방향을 보인 기간이 더 길었다. 2012년부터 2019년까지 전세 지수는 누적 64% 상승하였으나 동 기간 중 통합주거비지수는 5% 하락하면서 장기간 괴리를 보였다. 통합주거비지수와 전세 지수의 괴리는 금리 등 경제환경 변화와 연관되어 있다. 따라서 임대시장의 순수 가격 변화를 관찰하기 위해서는 금리에 민감한 전세 지수 이외에 통합주거비와 같은 월세 실거래 지수 작성이 긴요하다고 판단된다. In Korea, "Jeonse" has become the primary form of rental contract, making it difficult to directly observe pure rent trends. This study calculates an integrated new rent index that includes all types of rental transactions. By comparing the integrated new rent index and the Jeonse index from 2011 to 2023, we find that the new rent index often moves in a different direction than the Jeonse index. From 2012 to 2019, the Jeonse index cumulatively increased by 64%, while the new rent index decreased by 5% over the same period, highlighting a prolonged divergence. The divergence between the new rent index and the Jeonse index is associated with changes in the economic environment, such as interest rates. Therefore, in order to observe pure price changes in the rental market, it is crucial to create a new rent index instead of the Jeonse index, which is sensitive to interest rates.
오지윤,곽재환,권도영,김아영,오달석,제남경,이재원,정영석 한국독성학회 2014 Toxicological Research Vol.30 No.4
Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) havebeen implicated in cancer development and progression. However, the effects ofPAHs on carcinogenesis are still poorly understood. Here, we characterized amouse cancer cell line BNL 1ME A. 7R.1 (1MEA) derived by transformation of non-tumorigenic liver cell line BNL CL.2 (BNL) using 3-methylcholanthrene (3MC), acarcinogenic PAH. RT-PCR and immunoblot analysis were used to determine theexpression level of mRNA and proteins, respectively. To determine functionality, cellmotility was assessed in vitro using a transwell migration assay. Both mRNA andprotein levels of E-cadherin were significantly decreased in 1MEA cells incomparison with BNL cells. While the expression levels of mesenchymal markers and related transcription factors were enhanced in 1MEA cells, which could lead toincrease in cell motility. Indeed, we found that 7-day exposure of BNL cells to 3-MCreduced the level of the adhesion molecule and epithelial marker Ecadherinand increased reciprocally the level of the mesenchymal marker vimentin in a dose-dependent manner. Taken together, these results indicate that the process ofepithelial-mesenchymal transition (EMT) may be activated during premalignanttransformation induced by 3-MC. A mechanism study to elucidate the relationbetween 3-MC exposure and EMT is underway in our laboratory.