수종의 One-bottle 상아질 결합제의 전단 결합 강도에 관한 연구

오소희,김종수,권순원,Oh, So-Hee,Kim, Jong-Soo,Kwon, Soon-Won 대한소아치과학회 2001 대한소아치과학회지 Vol.28 No.4

One-bottle adhesive system was recently developed in order to simplify the clinical skills and save chair time after continuous improvements on dentin bonding agents. To test the shear bond strength of a new "one-bottle adhesive" system to bovine dentin various commercially available one-bottle adhesives(Prime & Bond $2.1^{(R)}$, One Coat $Bond^{(R)}$, Syntac $Sprint^{(R)}$, Single $Bond^{(R)}$) were included for comparison. And we observe the interfacial morphology by scanning electron microscope. The results were as follows; 1. Group II (One Coat $Bond^{(R)}$) showed higher shear bond strength than group I (Prime & Bond $2.1^{(R)}$), group III(Syntac $Sprint^{(R)}$), and group IV(Single $Bond^{(R)}$), but no statistically significant difference was founded between groups(p>.05). 2. Relating reverse-cone shape resin tags were observed in samples of all groups under SEM. We could observed hybrid layer, resin tag and many lateral branches in every group. But, we observed in group III rare lateral branched than other three groups, and discontinuous hybrid layer.

[행복일기] 생존이 삶으로 바뀌는 곳

오소희 샘터사 2013 월간 샘터 Vol.521 No.-

무용교사의 수행체험을 통해서 본 무용교육의 가치와 의미 : 자문화기술지를 통한 분석

오소희 무용역사기록학회(구 한국무용사학회) 2019 무용역사기록학 Vol.53 No.-

메타인지 향상을 위한 엔트리 프로그래밍 교육 콘텐츠 개발 및 적용

오소희,김응진,김성식,Oh, So-Hee,Kim, Eung-Jin,Kim, Seong-Sik 한국컴퓨터교육학회 2017 컴퓨터교육학회 논문지 Vol.20 No.5

The purpose of this study is to develop and validate the effects of the software education contents for enhancing metacognition of the cognitive issues that improve the creative problem solving ability. The experimental group was taught by entry programming class using the software education contents developed in this study while the control group was taught by traditional method for entry programming. To confirm the changes of two groups, metacognitive post t-test was performed and compared with pre t-test results. The analysis result of the post t-test showed the following: There are statistically significant differences between the experimental group and the control group at a significance level of 0.05 for the interest of the experimental group. Therefore it was confirmed that the programming classes using software contents is effective in improving the metacognition of students.

[행복일기] 부딪히면서 배워요

오소희 샘터사 2012 월간 샘터 Vol.513 No.-

Available Alternative Biologics and Disease Groups Influence Biologic Drug Survival in Patients with Psoriasis and Psoriatic Arthritis

오소희,최성준,윤현선 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5

Background: Factors other than efficacy and safety could influence the survival of biologics in patients with psoriasis. Little is known about whether different disease groups affect drug survival of biologics or not. Objective: This study aimed to investigate whether the availability of alternative biologics and disease groups could influence drug survival of biologics approved for psoriasis and psoriasis arthritis (PsA). Methods: A nationwide population-based retrospective cohort study was conducted using the Health Insurance and Review Assessment data in Korea between January 2009 and August 2019. Results: The drug survival analysis included 5,634 biologic episodes. Ustekinumab was the most frequently prescribed drug (n=2,488, 44.2%). Multivariable time-dependent Cox regression analysis showed that higher age, female sex, no comorbidity, concomitant cy- closporine or acitretin use, biologic-experienced and use of tumor necrosis factor (TNF)-α inhibitors were predictors of drug discontinuation. PsA was a predictor of drug persis- tence, particularly for TNF-α inhibitors. Ustekinumab and adalimumab discontinuation significantly increased after introducing secukinumab and ustekinumab, respectively. Conclusion: The availability of alternative biologics and disease groups affect biologic drug survival in patients with psoriasis and PsA.

Joint Identification of Multiple Genetic Variants of Obesity in a Korean Genome-wide Association Study

오소희,조서애,박태성 한국유전체학회 2010 Genomics & informatics Vol.8 No.3

In recent years, genome-wide association (GWA) studies have successfully led to many discoveries of genetic variants affecting common complex traits, including height, blood pressure, and diabetes. Although GWA studies have made much progress in finding single nucleotide polymorphisms (SNPs) associated with many complex traits, such SNPs have been shown to explain only a very small proportion of the underlying genetic variance of complex traits. This is partly due to that fact that most current GWA studies have relied on single-marker approaches that identify single genetic factors individually and have limitations in considering the joint effects of multiple genetic factors on complex traits. Joint identification of multiple genetic factors would be more powerful and provide a better prediction of complex traits, since it utilizes combined information across variants. Recently, a new statistical method for joint identification of genetic variants for common complex traits via the elastic-net regularization method was proposed. In this study, we applied this joint identification approach to a large-scale GWA dataset (i.e.,8842 samples and 327,872 SNPs) in order to identify genetic variants of obesity for the Korean population. In addition, in order to test for the biological significance of the jointly identified SNPs, gene ontology and pathway enrichment analyses were further conducted.

치아 우식증에 따른 치수내 유전자 발현 변화에 관한 분석

오소희,김종수,Oh, So-Hee,Kim, Jong-Soo 대한소아치과학회 2010 대한소아치과학회지 Vol.37 No.3

Deep caries may induce pulpitis and the pulpal tissue interacts with microbial invasion. The immune response to protect the pulpal tissue can be mediated by cellular signal molecules produced by the pulpal cells. The understanding of these processes is important to find future therapeutic method for the diseased pulp. The pulp tissue from sound teeth was set as control group (n=30) and the pulp tissue from decayed teeth was set as test group (n=30). Total RNA was extracted from the pulp of each group and it was used for cDNA microarray and reverse transcriptase-polymerase chain reaction(RT-PCR). The expression of TGF-${\beta}1$ was studied by immunohistochemistry. The results were as follows: 1. cDNA microarray analysis identified 520 genes with 6-fold or greater difference in expression level with 143 genes more abundant in health and 377 genes more abundant in disease. 2. The RT-PCR analysis was done for randomly selected 14 genes and the results supported the result of cDNA microarray assay. 3. TGF-${\beta}1$ was highly expressed in the carious pulp and it was found in odontoblast by immunohistochemistry. In conclusion, many cytokines were found to be significantly changed their expression in the diseased pulp(/M/>1.6).

외배엽 이형성증 환자의 임상적 치험례

오소희,권순원,김종수,김용기,임헌송 대한소아치과학회 2000 대한소아치과학회지 Vol.27 No.2

Ectodermal dysplasia(외배엽 이형성증)은 외배엽성 기관에 한가지 이상의 선천적 이상소견을 특징으로 하는 질환이다. Ectodermal dysplasia는 약 120종류 이상이 보고되고 있고, 이 중 Hypohidrotic ectodermal dysplasia가 가장 잘 알려져 있으며 이는 성염색체 열성인자에 의해 유전되며 남성에서 호발한다고 한다. 임상증상으로는 무한증, 감모증, 무치증 혹은 핍지증이 가장 특징적이다. 이외에도 무피지증, 손톱이형성증, 가늘고 성긴 머리카락, 두드러진 이마, 안장코, 돌출된 안와상부, 입술의 돌출과 함께 피부가 건조하고 땀샘이 결핍되어 있어서 더위를 참지 못하고 발열이 일어나기 쉽다. 본 증례의 환자는 단국대학교 치과병원 소아치과에 내원한 6세 6개월된 남아로써 무치증을 보이는 Hypohidrotic ectodermal dysplasia로 진단되었고 환자의 심미적, 기능적 결함을 해소하기 위해 총의치로 치료를 시행하는 동안 다소의 지견을 얻어 이를 보고하는 바이다. 주요어 : 외배엽 이형성증, 무치증, 총의치

더덕 에탄올 추출물의 도시미세먼지 노출로 인한 폐 세포 산화스트레스 발생과 세포밀착연접 손상 억제 효과

소희정(Hee-Jung So),전수현(Su-Hyun Chun),이진원(Jin-Won Lee),이광원(Kwang-Won Lee) 한국식품과학회 2021 한국식품과학회지 Vol.53 No.2

본 연구에서는 UPM에 의해 유발되는 NCI-H441 세포 내 ROS 생성과 그에 따른 tight junction 단백질(N-cadherin, fibronectin, occluding, ZO-1, 및 claudin-4 등)의 발현 억제를 확인하였고 ECL의 전처리로 인하여 해당 ROS 생성 및 tight junction 단백질 발현 억제 현상이 완화되는 보호효과를 확인하였다. 그 결과, 폐 세포에서 UPM에 의해 유발된 산화 스트레스 및 tight junction 단백질의 발현 감소가 ECL을 선 처리함으로써 억제되어 결과적으로 산화 스트레스와 같은 미세먼지에 의한 폐 손상으로부터 보호 효과를 나타내고 tight junction 수준의 유지를 확인하였다. 이러한 결과를 통해 ECL 추출물은 폐와 기관지의 보호효과를 나타내며 폐 관련 질병의 예방효과가 있는 기능성 천연 물질로써 활용이 가능할 것으로 기대된다. One of the major sources of air pollution is urban particulate matter (UPM), which causes lung diseases involving oxidative stress, inflammation, and cancer. Codonopsis lanceolata (CL) has been used in East Asia as a traditional oriental medicinal ingredient for lung diseases (e.g., asthma and bronchitis). However, the connection between the impact of CL and UPM in the lungs has rarely been investigated. This study aimed to confirm the inhibitory activity of the ethanol extract of CL (ECL) against oxidative stress and disruption of tight cell junctions in human pulmonary epithelial cells after exposure to UPM. As the lung cells were pre-treated with ECL, the UPM-induced increase in cellular reactive oxygen species production suppressed tight junction proteins (e.g., N-cadherin, fibronectin, occludin, zonula occludens-1, and claudin-4). These results suggest that ECL prevents the possible effects of UPM toxicity on the lungs.