Prostate-Specific Membrane Antigen PET Imaging in Prostate Cancer: Opportunities and Challenges

오소원,천기정 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.5

The aim of this systematic review was to describe the characteristics of prostate-specific membrane antigen (PSMA)-targeting PET and their clinical applications in prostate cancer patients. There have been major strides in the design, synthesis of PSMA-targeting PET tracers over the past several years. PSMA-targeting PET tracers can be categorized, according to positron emitters and targeting strategies for the PSMA. The majority of PSMA PET studies has been focused on patients with biochemical recurrence, but additional values of PSMA PET have also been investigated for use in primary staging, treatment planning, response evaluation, and PSMA radioligand therapy. PSMA PET is expected to bring improvements in the management of patients, but the impact of improved diagnosis by PSMA on overall survival remains unanswered. Many challenges still await PSMA PET to expedite the use in the clinical practice. At this early stage, prospective multicenter trials are needed to validate the effectiveness and usefulness of PSMA PET.

Current Status of PSMA-Targeted Radioligand Therapy in the Era of Radiopharmaceutical Therapy Acquiring Marketing Authorization

오소원,천기정,서민석 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.6

Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors,metastatic tumors, and tumors nonresponsive to androgen deprivation therapy. PSMA has been a topic of interest during thepast decade for both diagnostic and therapeutic targets. Radioligand therapy (RLT) utilizes the delivery of radioactive nuclidesto tumors and tumor-associated targets, and it has shown better efficacy with minimal toxicity compared to other systemiccancer therapies. Nuclear medicine has faced a new turning point claiming theranosis as the core of academic identity, sincenew RLTs have been introduced to clinics through the official new drug development processes for approval from the Foodand Drug Administration (FDA) or European Medical Agency. Recently, PSMA targeting RLT was approved by the USFDA in March 2022. This review introduces PSMA RLT focusing on ongoing clinical trials to enhance our understandingof nuclear medicine theranosis and strive for the development of new radiopharmaceuticals.

방사성요오드 치료저항성 갑상선암에서 방사성요오드 병용치료의 새로운 전략

오소원,팽진철,정준기 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.1

The prognosis of differentiated thyroid cancer (DTC) is excellent, which is mainly due to the high therapeutic efficacy of radioactive iodine (RAI) therapy as well as indolent nature of thyroid cancer itself. Although most patients with DTC are well treated with RAI therapy, a certain number of patients have been suffered from refractoriness to RAI therapy. To overcome refractoriness, many alternative treatments have been investigated, and they could be classified based on the mechanisms of action; redifferentiation drug and molecular targeted drug. Not only redifferentiated drugs but also molecular targeted drugs could induce differentiation of thyroid cancer cells. Consequently, alternative treatments allowing tumor cells of RAI avidity followed by RAI therapy could utilize a synergistic effect of both therapies. Combined RAI therapy is expected to improve therapeutic effects and prognoses of RAI refractory thyroid cancers.

A correlation between comprehensive neck dissection and increased uptake around the sternoclavicular joint on post-operative 18F-FDG PET/CT

오소원,이도영,김보해,김광현,김유경,정영호,Oh, So Won,Lee, Doh Young,Kim, Bo Hae,Kim, Kwang Hyun,Kim, Yu Kyeong,Jung, Young Ho The Korean Society for Head and Neck Oncology 2018 대한두경부 종양학회지 Vol.34 No.1

Background/Objectives: This study aimed to evaluate the changes of uptake around the sternoclavicular joint (SCJ) according to 18F-FDG PET images in patients with head and neck cancer who underwent neck dissection. Materials & Methods: Retrospectively, the medical records of patients who received selective or comprehensive neck dissection were reviewed. Preoperative and 1-year postoperative 18F-FDG PET images, if available, were analyzed by nuclear medicine physicians in both qualitative and quantitative manners. Correlation between the changes of uptake around SCJ and perioperative data were statistically analyzed. Results: Thirty-seven patients satisfying the inclusion criteria were enrolled. Seven patients with increased uptake around SCJ on 1-year postoperative 18F-FDG PET showed a correlation with radical or comprehensive neck dissection, accessory nerve sacrifice, and high postoperative SUVmax. When 20 patients with increased uptake around SCJ according to quantitative measurement were compared with other patients without increased uptake, no parameter was significantly different, except postoperative SUVmax. Bivariate logistic regression analysis revealed that the clinical symptom (shoulder or sternal pain) was significantly correlated with the extent of neck dissection (OR 0.227, CI 0.053-0.966, p=0.045) and spinal accessory nerve sacrifice (OR 13.500, CI 1.189-153.331, p=0.036). Conclusions: Increased uptake around SCJ on 1-year postoperative 18 F-FDG PET was correlated with either the radical or comprehensive procedure, as well as with accessory nerve sacrifice. This suggests that subjective analysis of 18F-FDG PET can be used to detect subclinical shoulder instability.

The effects of negative emotions on binge eating among bulimics: Comparisons among anger, anxiety, and depression

소원현 한국건강심리학회 2009 한국심리학회지 건강 Vol.14 No.2

The goal of this study was to investigate the influences of overall and specific negative emotions affecting eating behaviors, especially, binge eating. This study first examined the influence of each specific negative emotion (anxiety, anger, and depression) on binge eating of bulimics through self-report questionnaires, and then conducted a laboratory experiment in order to clarify a causal relationship between binge eating and anxiety. With 357 results of BULIT-R, K-EAT, DEBQ, and EES tests, this study first showed that negative emotions had significant correlations with binge eating. Moreover, it also demonstrated that anxiety was the most influential negative emotion that affected eating behaviors by bulimic and normal eaters. The laboratory experiments were conducted with 52 participants in order to examine a causal relationship between anxiety and binge eating. The result indicated that bulimic eaters eat more when they are irritated or worried, but normal eaters eat less in the same situation.

Low-rate TCP 공격 탐지를 위한 스케일링 기반 DTW 알고리즘의 성능 분석

소원호,심상헌,김영천,유경민 대한전자공학회 2007 電子工學會論文誌-TC (Telecommunications) Vol.44 No.3

In this paper, low-rate TCP attack as one of shrew attacks is considered and the scaling based dynamic time warping (S-DTW) algorithm is introduced. The low-rate TCP attack can not be detected by the detection method for the previous flooding DoS/DDoS (Denial of Service/Distirbuted Denial of Service) attacks due to its low average traffic rate. It, however, is a periodic short burst that exploits the homogeneity of the minimum retransmission timeout (RTO) of TCP flows and then some pattern matching mechanisms have been proposed to detect it among legitimate input flows. A DTW mechanism as one of detection approaches has proposed to detect attack input stream consisting of many legitimate or attack flows, and shown a depending method as well. This approach, however, has a problem that legitimate input stream may be caught as an attack one. In addition, it is difficult to decide a threshold for separation between the legitimate and the malicious. Thus, the causes of this problem are analyzed through simulation and the scaling by maximum auto-correlation value is executed before computing the DTW. We also discuss the results on applying various scaling approaches and using standard deviation of input streams monitored. 본 논문에서는 최근 새롭게 발견된 low-rate TCP (LRT) 공격과 이 공격을 감지하기 위한 DTW (Dynamic Time Warping) 알고리즘을 분석하고 공격 검출에 대한 성능 향상을 위한 스케일링 기반 DTW (Scaling based DTW; S-DTW) 알고리즘을 소개한다. Low-rate TCP 공격은 대용량 트래픽을 사용한 기존 서비스 거부 공격과는 다르게 공격 트래픽의 평균 트래픽 양이 적어서 기존 DoS 공격에 대한 감지 방식으로는 검출되지 않는다. 그러나 LRT 공격은 주기적이고 짧은 버스트 트래픽으로 TCP 연결의 최소 재전송 타임아웃 (Retransmission Timeout; RTO)에 대한 취약성을 공격하기 때문에 패턴 매칭으로 공격 감지가 가능하다. 기존 메커니즘에 의한 감지 기법은 공격 패턴의 입력 샘플 템플릿을 기준으로 입력 트래픽이 정상 트래픽인지 또는 공격 트래픽인지를 판별한다. 이 과정에서 입력 트래픽의 특성에 따라서 DTW 알고리즘은 정상 트래픽을 공격 트래픽으로 오판하는 문제점을 갖는다. 따라서 본 논문에서는 이러한 오판을 줄이기 위하여 기존 DTW 알고리즘의 전처리 과정인 자기상관 (auto-correlation) 처리를 분석하여 오판을 규명한다. 또한 스케일링 기반으로 자기상관 처리 결과를 수정하여 공격 트래픽과 정상 트래픽의 특성의 차이를 증가시킴으로써 DTW 알고리즘에 의한 공격 감지 능력을 향상시킨다. 마지막으로 다양한 스케일링 방식과 표준편차에 의한 트래픽 분석 방법도 논의된다.

80年代 새로운 運送秩序의 摸索 <上>

小原三佑嘉 한국해사문제연구소 1978 (月刊)海洋韓國 Vol.53 No.-

한국 수산물 가공식품기업의 이미지가 제품평가 및 구매의도에 미치는 영향

소원현 ( Won Hyun So ),김하균 ( Ha Kyun Kim ) 한국수산경영학회 2013 수산경영론집 Vol.44 No.1

The purpose of this study is examining an influence of a corporate on processed marine product`s purchase intention with moderating effect of consumers` product evaluation adding processed marine product`s evaluations as new variable. The hypothesis of a positive influence of processed marine product`s corporate image on processed marine product`s purchase intension is partially supported. Specifically, product itself, service, reliability, and communication among the factors of a processed marine product`s corporate image significantly affect processed marine product`s purchase intension whereas corporate social responsibility does not affect processed marine product`s purchase intention. Processed marine product`s evaluation also positively affects processed marine product`s purchase intention. It implies that there are somewhat differences between influences of various factors of a processed marine product`s corporate image on processed marine product`s purchase intention but are overall influences of a processed marine product`s corporate image on processed marine product`s evaluation both directly and indirectly. Nowadays, consumer considers not only good quality of product but also its invisible image and value. Therefore, future studies should consider various ways to investigate a processed marine product`s corporate image and processed marine product`s product evaluation.

Region 기반 라우팅 구성 요소의 효율적 운용을 위한 무선 라우팅 프로토콜의 성능 분석

소원호(Wonho So),김진일(Jinil Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11

As new services continue to emerge and service functions become more and more complicated, it is clear that no single wireless mobile routing protocol can fit all the needs. In this paper, in order to show a simple approach for the end, R-AODV (Region based Ad-hoc On-Demand Distance Vector) protocol which includes a function of region based routing is proposed and evaluated in terms of throughput, delay, and routing overhead.

광 버스트 교환 망을 위한 GMPLS 기반 기능 모델과 연결 수락 제어 알고리즘

소원호,노선식,김영천 한국통신학회 2004 韓國通信學會論文誌 Vol.29 No.9