백서에서의 개두술 또는 비개두술적 방법에 의한 영구적 중대뇌동맥 폐쇄술에 관한 비교 관찰 : Evaluation of the Model With or Without Craniectomy

오세문,정병주,이종인,최선길,강성구 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.1

The purpose of our present study was to asses the effectiveness of middle cerebral artery occlusion in producing acute focal cerebral ischemia in rats by use of Bederson's or Longa's method in which occlusion was performed with or without craniectomy respectively. In twenty-nine Spraye-Dawley rats weighing 25@3OOgm, right middle cerebral artery occlusion was achieved by use of either Bederson's method or Long's method. After 4 hours of ischemia. neurological evaluation was performed and then brain water content was determined in the central. intermediate. and outer zones of each cortical mantle. In both groups, a significant neurological deficit caused by focal cerebral ischemia was observed. More severe neurological deficit was achieved by Longa's method than by Ekderson's method(p<0.001). In Bederson's method group. significant brain edema was observed only in the ischemic central and intermediate zones. However, in Longa's method group, significant brain edema was observed in all of the three ischemic zones. And more severe brain edema was achieved by Longa's method in each of three ischemic zones than by Bederson's method (p<o.OOl, respectively). Theses results incicate that Longa's metl-d is more effective and persistent method in producing acute focal cerebral ischemia than Bederson's method. Longa's method is considered as one of a good. less invasive, and technically easy method to achieve focal cerebral ischemia in rats.

외래 잡초인‘단풍잎돼지풀’의 발생소장 및 효율적 방제

오세문,O, Se-Mun 한국작물보호협회 2006 자연과 농업 Vol.27 No.8

전단 링크보의 이력 거동 및 변형능력

오세문,김태영,김정석,김상섭,김규석 대한건축학회 2001 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.21 No.2

The length of the links in eccentrically braced frame will dictate the behavior of the frame. Link length controls the yielding mechanism and the ultimate failure mode. For short links, the link shear forces reaches the plastic shear capacity before the end moments reach the plastic moment capacity, and the link yields in shear, forming a shear hinge. These links are termed shear links. For long links, the end moments reach the plastic moment capacity before the link shear forces reaches the plastic shear capacity, forming moment hinges. These links are termed moment links. In long links, flexural yielding dominates the response, and very high bending strains are required at the link ends to produce large link deformations. In a shear links the shear force is constant along the length of the link, and inelastic shear strain are uniformly distributed over the length of the link. This permits the development of large inelastic link deformations without the development of excessively high local strains. In this paper experimental program is conducted to assess the response of shear links m eccentrically braced frame. Twelve specimens are tested using a cyclic load.

제초제 사용 40년, 수도용 제초제 생산과 잡초발생 양상(2) - 저성분.고활성 제초제 보급 계열 다른 약제 바꾸어 사용해야

오세문,O, Se-Mun 한국작물보호협회 2009 자연과 농업 Vol.248 No.-

제초제가 보급되면서 분명 벼 재배의 생력화는 누구도 부인할 수 없을 것이다. 농업인들은 저항성 잡초가 발생하지 않도록 계열이 다른 약제를 바꾸어 가며 사용하고, 이미 발생된 포장에는 빠른 기간 내에 제거될 수 있도록 제초제를 체계적으로 잘 사용하여야 한다.

Effects of Oxygen-Derived Free Radicals on Brain Microsomal $Na^+-K^+-ATPase$ Activity

오세문,손영숙,최길수,임정규,정명희,Oh, Sae-Moon,Son, Young-Sook,Choi, Kil-Soo,Lim, Jung-Kyoo,Chung, Myung-Hee The Korean Society of Pharmacology 1982 대한약리학잡지 Vol.18 No.2

중추신경계의 혈관폐쇄 또는 충격손상에 의한 허혈병소에서 진행되는 병리적 변화에 산소유리라디칼이 중요한 역할을 할 것으로 시사되고 있다. 저자는 산소유리라디칼이 뇌조직에 미치는 영향 중 특히 신경세포 정지막전위 유지에 중요한 $Na^+-K^+-ATPase$의 활성도에 미치는 영향을 관찰하기 위하여 산틴산화효소 반응계와 뇌조직미크로좀을 이용하여 본 연구를 시행하였다. 미크로좀분획(microsomal fraction)을 산틴과 산틴산화효소와 함께 반응시켰을 때, 분획의 $Na^+-K^+-ATPase$의 활성도는 현저한 불활성화를 보인 반면, $Mg^{++}-ATPase$의 활성도는 별로 영향을 받지 않았다. 이 불활성화는 산틴과 신틴산화효소 중 어느 한 물질이라도 반응계에 존재하지 않는 경우에는 나타나지 않았고, 두 물질이 같이 반응계에 존재할 때 나타났다. 산틴과 산틴산화효소의 반응에서 생성되는 산소유리라디칼들 중, 어떤 것이 $Na^+-K^+-ATPase$불활성화에 관계하고 있는가를 알아보기 위하여, 산수유리라디칼 각각에 대하여 제독작용을 가진 효소나 화학물질을 사용하여 불활성화의 저해유무를 관찰하였다. $O_{\bar{2}}{\cdot}$의 제독효소인 superoxide dismutase, $H_2O_2$의 제독효소인 catalase와 $^1O_2$의 제독물질인 1,4-diazabixyclo(2,2,2)octane을 각각 사용하였을 때, 이들 물질들이 농도에 비례하여 $Na^+-K^+-ATPase$의 불활성화가 저해되었다. 그러나 $OH{\cdot}$의 제독물질인 mannitol은 뚜렷한 효과를 보이지 못했다. 이상의 결과는 산소유리라디칼들 중 $O_{\bar{2}}{\cdot},\;H_2O_2$ 및 $^1O_2$가 $Na^+-K^+-ATPase$의 불활성화에 관계하고 있고, $OH{\cdot}$는 거의 관계하지 않는다는 것을 시사하여 주었다. 이로 미루어, 산소유리라디칼에 의한 뇌조직 $Na^+-K^+-ATPase$의 불활성화는 뇌 허혈병소에서 관찰되는 신경세로의 기능적 장해를 유발시키는 한 요인으로 사료되었다. The effects of xanthine-xanthine oxidase reaction on brain microsomal $Na^+-K^+-ATPase$ activity were studied to see possible involvement of oxygen free radicals in pathologic change occurring in ischemic state of CNS accompanied by cerebral vascular occlusion or impact injury. When microsomal fraction was incubated with xanthine ana xanthine oxidase, $Na^+-K^+-ATPase$ activity of the fraction was markedly inactivated (80% inactivation) whereas btssl $Mg^{++}-ATPase$ was much less sensitive (less than 10% inactivation) compared to that of $Na^+-K^+-ATPase$. The inactivation was observed only in the presence of both xanthine and xanthine oxidase, not either of them alone, and the extent of inactivation was dependent on the concentration of xanthine. In an attempt to determine which of the oxygen species was responsible for the inactivation, the ability of various scavengers to overcome the inactivation was tested. Superoxide dismutase, catalase and 1,4-diazabicyclo(2,2,2)octane were shown to reverse the inactivation of the ATPase in dose-dependent manner. In contrast, mannitol as well as other $OH{\cdot}$quenchers were ineffective in limiting oxygen radical-induced inactivation. Thus $O_{\bar{2}}{\cdot},\;H_2O_2$ and $^1O_2$ were implicated to be mediators involved in the inactivation. Since oxygen radicals are suspected as being a cause of the peroxidative damaging process in train ischemia, the ATPase inactivation by oxygen radicals may be a possible contributing factor which gives rise to functional derangement of nerve cells observed in the pathologic process.

특별강연 및 학술연구 발표요지 : 외래잡초 발생 현황과 관리 대책

오세문 한국잡초학회 2007 한국잡초학회 별책(학술대회 초록집) Vol.27 No.2

저선량에서의 TrueX 재구성 방법에 의한 유용성 평가

오세문,김계환,김승정,이홍재,김진의,Oh, Se-Moon,Kim, Kye-Hwan,Kim, Seung-Jeong,Lee, Hong-Jae,Kim, Jin-Eui 대한핵의학기술학회 2011 핵의학 기술 Vol.15 No.2

Purpose: Recently in diagnostics area PET/CT is using a variety of areas including oncology, as well as in cardiology, neurology, etc. While increasing in the importance of PET/CT, there are various researches in the image quality related to reconstruction method. We compared and tested Iterative 2D Reconstruction Method with True X Reconstruction method by Siemens through phantom experiment, so we can see increasing of clinical usefulness of PET/CT. Materials and Methods: We measured contrast ratio and FWHM due to evaluating images on dose and experiment using Biograph 40 True Point PET/CT (Siemens, Germany). Getting a result of contrast ratio and FWHM, we used NEMA IEC PET body phantom (Data Spectrum Corp.) and capillary tube. We used the current TrueX and the previous Iterative 2D algorithm for all images which have 10 minutes long. Also, a clinical suitability of parameter for Iterative 2D and a recommended parameter by Siemens for True X are applied to the experiment. Results: We tested FWHM using capillary tube. As a result, TrueX was less than Iterative 2D. Also, the differences of FWHM get bigger in low dose. On the other hand, we tested contrasts ratio using NEMA IEC PET body phantom. As a result, TrueX was better aspect than Iterative 2D. However, there was no difference in dose. Conclusion: In this experiment, TrueX get higher results of contrast ratio and spatial resolution than Itertive 2D through experiment. Also, in the reconstruction result through TrueX, TrueX had better aspect of resolution than Iterative 2D in low dose. However, contrast ratio had no specific difference. In other words, TrueX reconstruction method in PET/CT had higher clinical value in use because TrueX can reduce exposure of patient and had a better quality of screen.

불안정 경추손상 23례의 치료후 안정성 복원에 관한 임상적 고찰

오세문,최선길 한림대학교의료원 1989 人間科學 Vol.13 No.3

리뷰 - 제초제 사용 40년, 수도용 제초제 생산과 잡초발생 양상(1)

오세문,O, Se-Mun 한국작물보호협회 2009 자연과 농업 Vol.247 No.-

1990년 중반이후 저항성 잡초에 대한 방제체계가 확립되지 못함에 따라 제초제의 사용량이 더욱 늘었다. 그러다가 2000년 이후부터 단위 면적당 투여량이 적은 제초제가 늘면서 유효성분 함량이 낮은 약제끼리 합제로 개발되고 있어 성분이 낮은 제초제가 많이 늘어나고 있다.

기고 - 생활주변 악성 잡초 제거로 '푸른 농촌 희망 찾기'

오세문,O, Se-Mun 한국작물보호협회 2010 자연과 농업 Vol.254 No.-

우리 생활주변의 문제 잡초를 제거하는 일이 곧 깨끗한 농촌을 만들어 갈수 있는 중요한 과정이므로 범정부적 차원에서 이들 잡초 제거에도 관심을 갖도록 해야 할 것이다.