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오남묵,오경택,윤유석,이덕근,차경휘,이은성 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.1
Tiotropium, a longer acting anticholinergic bronchodilator, has been widely used for treatment of chronic obstructive pulmonary disease (COPD). To improve the therapeutic effect of tiotropium, we developed various inhalation microparticular formulations of tiotropium using starch, hyaluronate, bovine serum albumin (BSA), and poly(lactide-co-glycolide) (PLGA). All formulations showed *90 % inhalation efficiency in the lung epithelium of BALB/c mice after initial administration. Interestingly, when compared to other formulations using starch, hyaluronate, and BSA, the inhalation formulation of tiotropium using PLGA showed longer drug residence (up to 7 days) in in vivo lung epithelium. We believe that this microparticle system is expected to improve the treatment efficacy for the patients with COPD by maintaining drug therapeutic effect during the extended period after initial inhalation.
이민지,이은성,오남묵,오경택,윤유석 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
We developed novel poly(L-lysine) [poly(Lys)]derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemicalreaction of poly(Lys) and 3-diethylaminopropyl isothiocyanate(DEAP), and was coupled with poly(ethyleneglycol) (PEG). The obtained poly(Lys-DEAP)-b-PEG wascrosslinked by genipin (crosslinking agent) in an oil/wateremulsion condition, producing poly(Lys) derivative nanogels. These nanogels (*95 nm in diameter, pH 7.4)showed volume expansion (*200 nm in diameter) in theendosomal pH (*pH 6.0) due to extensive protonabsorption of DEAP moieties in the crosslinked nanogelcore. These nanogels reversibly swelled at pH 6.0 andshrank at pH 7.4, correspond to maximized drug release atpH 6.0 and minimized drug release at pH 7.4. We concludethat this nanogel system will have great potential for tumortherapy.
Preparation of Chlorine e6-Conjugated Single-Wall Carbon Nanotube for Photodynamic Therapy
이동진,이은성,박소영,오영택,오남묵,오경택,윤유석 한국고분자학회 2011 Macromolecular Research Vol.19 No.8
We fabricated single-wall carbon nanotubes (SWNTs) modified with chlorine e6 (as a photosensitizing drug: Ce6) and poly(ethylene glycol) (PEG, as a polymeric stabilizer) were fabricated to develop a light-sensitive nanovehicle for tumor treatment. The carboxyl group of Ce6 and poly(ethylene glycol) (PEG) was coupled with aminated SWNT via N,N'-dicyclohexyl carbodiimide (DCC)- and N-hydroxysuccinimide (NHS)-mediated amide formation. During light irradiation, singlet oxygen generation from Ce6 coupled to the SWNTs was reduced due to the quenching effect of SWNTs for Ce6. Unlike free Ce6, Ce6 coupled to the SWNTs accumulated to a significant degree in the tumor site, reflecting its pharmaceutical potential under in vivo conditions. This might become a potential carrier system for improving photodynamic therapy.