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Cimetidine 및 16 , 16 - dimethyl prostaglandin E2 가 흰쥐 위액분비 및 위궤양형성에 미치는 영향
이기환(Ki Whan Lee),김종숙(Chong Sook Kim),박실무(Sil Moo Park),박병국(Byung Goog Park),차광수(Kwang Soo Cha),서승천(Seung Cheon Seo),엄석준(Souk Jun Um) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.2
N/A the effect of prostaglandin E2 and cimetidine on acute gastric mucosal lesions produced by topical aspirin(200 mg/kg) plus HCI(150 mM) in the pylorus ligated rats were studied. 16, 16-dimethyl prcstaglandin E2 and cimetidine significantly reduced gastric juice secreticn, pH and acid output. A 1so 16, 16-dimethyl prostaglandin E2 and cimetidine significantly reduced acute gastric muicosal lesion although acid was given exogenously so as to negate any antisecretory effect of the drugs studied. We conclude that both 16, 16-dimethyl prostaglandin E2 and cimetidine reduced gastric juice secretion, pH, and acid output and also protect gastric mucosal lesion by some means other than their effect on acid output.
위십이자장 점막내 Prostaglandin E_2치에 관한 연구
엄석준,김종숙 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.3
Prostaglandin E₂may play the role in the control of gastric seretion, protective action of gastric mucosa and may be involved in pathophysiologic precess of the peptic ulcer. PGE₂was measured by radioimmunoassay in endoscopic biopsy specimens obtained from 12 healthy volunteers, 6 patients with duodenal ulcer, 9 with chronic gastritis, and 6 with intestinal metaplasia. We also studied the effects of indomethacin on PGE₂levels in rat gastric mucosa. The results were as follows: 1. In the healthy volunteers, mean PGE₂value of antral mucosa was 302.12±132.21ng/g,which was higher than that of the body with 171.17±87.34ng/g(p<0.05), or that of the duodenum with 54.66±32.86ng/g(p<0.01). The PGE₂levels of the duodenum was significantly lower than that of the body. 2. In the 6 patients with duodenal ulcer, mean PGE₂level of duodenal bulb was 42.21±11.01ng/g,which was lower than that of the antrum with 145.28±21.54ng/g, or that of the body with 127.83±86.31ng/g(p<0.01). Antral PGE₂level in patients with duodenal ulcer was lower than that of the healthy volunteers(p<0.05). However, there was no significant difference in PGE₂level of the body and that of the duodenal bulb. 3. In patients with chronic gastritis, there was no significant difference in PGE₂level of the antrum, body, and the duodenal bulb from those of the healthy volunteers. However, in patients with intestinal metaplasia, PGE₂levels from allareas were significantly lower than those from all other patients. 4. In all four groups, the mucosal PGE₂levels of the duodenal bulb were significantly lower than those of the antrum and the body. 5. In the animal studies, mean antral PGE₂values of the rat was 130.12±77.47ng/g, which was higher than that of the body with 91.51±85.09ng/g, but the difference was not significant. 6. With indomethacin treatment, the mucosal PGE₂level of the antrum and body was significantly lower than that of control group, and the treatment with 20 ㎍/㎏ of indomethacin resulted in a great decrease in PGE₂level than that with 6㎍/㎏ of indomethacin. As a result, gastric and duodenal mncosal PGE₂levels were different from those of gastric body, antrum and duodenal bulb, and PGE₂level may be one of the pathophysiologic factors of duodenal ulcer. Lower PGE₂levels were observed in patients with intestinal metaplasia, the cause of these lower values are unknown and need further study.