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양현일,강진석 남서울대학교 2014 남서울대학교 논문집 Vol.20 No.1-2
Test substance is a novel selective peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with a thiazolidinediones (TZDs) structural motif, and is expected to improve insulin sensitivity and blood lipid profiles in non-insulin dependent diabetes mellitus (NIDDM). However, existing PPAR-γ agonist by TZDs have been reported, this is accompanied by the induction of several undesirable side effects such as cardiovascular diseases (CVD). In this study, we investigated potential cardiotoxicity of test substance and compared its toxicity with that of rosiglitazone (RGT) or pioglitazone (PGT) in ZDF rats. After 7 weeks repeated administration of test substance at doses of 2.5, 5 and 10 mg/kg/day or RGT at dose of 40 mg/kg/day or PGT at dose of 300 mg/kg/day, animals were sacrificed for study of potential toxicities. Histopathological examination of heart was carried out and areas of cardiomyocytes were measured. And lipid accumulation and apoptosis in heart muscle were examined by oil red O staining and TUNEL staining, respectively. All test chemical induced the myocardial cell hypertrophy to varying degrees. And administration-dependent increasing tendency to myocardial cell hypertrophy was observed in RGT and PGT treatment groups. However, myocardial cell hypertrophy were not increasing tendencies of proportional relation to dose levels in test substance dose treatment groups. RGT, PGT or test substance low dose treatment groups induced significant increase in the area of cardiomyocytes in heart compared to control (p<0.01), in regular order as PGT , RGT and test substance. However, lipid accumulation and apoptotic changes in heart were not detected in all dosing groups. Taken together, the myocardial cell hypertrophy of test substance was relatively lower than that of RGT or PGT. It was suggested that test substance might be expected to become a useful antidiabetic agent for further preclinical and clinical study.
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장애인활동보조인의 직무만족에 미치는 영향 : 장애인에 대한 태도와 소진을 중심으로
양현일,박석돈 한국장애인재활협회 2012 재활복지 Vol.16 No.3
본 연구는 활동보조인의 장애인에 대한 태도와 소진이 직무만족에 미치는 영향을 분석함으로써, 활동보조인의 직무만족도를 향상시킬 수 있는 방안을 모색하는데 연구목적이 있다. 활동보조인의 장애인에 대한 태도가 직무만족도에는 친교의 거부가 영향을 미치는 것으로 나타났으며, 소진의 경우 감정적 고갈과 성취감 결여가 근무환경과 전체 직무만족도에 영향을 미치는 것으로 나타났다. 장애인에 대한 태도와 소진이 직무만족도에 미치는 영향을 분석한 결과 감정적 고갈과 성취감 결여, 친교의 거부와 기능제한의 요인이 영향을 미치는 것으로 나타났다. 연구결과를 통해 볼 때 장애인에 대한 태도를 긍정적으로 형성할 수 있는 프로그램이 필요하며, 동료상담이나 슈퍼비전과 같은 소진의 예방책과 승급체계 및 추가적인 인센티브가 필요할 것이다. The purpose of this study is to find strategies for promoting job satisfaction of personal assistants for the disabled by analyzing how attitudes of personal assistants for the disabled to disabled people and their burnout affect their job satisfaction. The major results of this study that are summarized as follows: First, rejection of intimacy negatively affected to job satisfaction. Second, emotional exhaustion and lack of achievement negatively affected job environment and overall job satisfaction. Third, rejection of intimacy, emotional exhaustion negatively, emotional exhaustion and lack of achievements affected job satisfaction. Regarding the results of this study, suggestions to promote job satisfaction of personal assistants for the disabled are as follows: First, it might be effective to prepare previous basic education programs including field placement programs for personal assistants for the disabled in order to make their attitudes to disabled people positively. Second, it might be necessary to prepare some programs such as colleague counseling programs, supervision and promotion systems in order to prevent burnout of personal assistants for the disabled.
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양현아(Yang Hyunah) 한국사회학회 2002 韓國社會學 Vol.36 No.5
본 논문은 호주제도의 존속과 현실가족의 변화라는 문제를 중심으로 하여 20이년 3월 서울지방법원에서 내려진 호주제도 위헌법률심판의 제청결정을 법사회학적으로 조망한다. 이를 위해 위헌심판이 제정된 사건의 내용과 그에 관한 재판부의 담론을 분석하고, 핵가족화 논의를 중심으로 한국가족의 변화와 호주제도의 성격을 살펴본다. 이어서 호주 제도라는 제도적 ‘가족’이 실제 ‘가족들’ 속에서 어떠한 양상으로 작동하는지를 인구 및 주택 총조사에서 드러난 가구변화 추이를 통해서 살펴본다. 여기서는 (1) 가족의 소규모화, (2) 출생아 성비, (3) 이혼 및 재혼 양상을 호주제도의 제도적 원리와 대응시키면서 살펴보았다. 그 결과, 가구변동에서 나타나는 소규모화 양상과 아들을 필요로 하는 호주의 승계제도와는 구조적으로 부조응하다는 것을 알 수 있었다(괴리). 하지만 성비 불균형은 호주의 승계제도가 소규모 가족들 속에서 무리하게 실현되어 왔다는 것을 말해준다(실현). 다른 한편, 이혼 및 재혼관계를 가진 가족 등 호주제도의 틀 속에서 ‘비정상적’ 가족으로 규정되는 가족이 급증하고 있다(억압). 이렇게 볼 때, 본 호주제 위헌소송은 개별 사건의 당사자에 국한된 사익(私益)이 아니라 사회적이고 역사적 맥락 속에서 바라본 공익(公益)의 관점에 섰을 때에만 그 판단기준이 명확히 설 수 있다는 것을 밝히면서 이번 소송에 있어 사회학적 전망의 중요성을 강조한다. This is a study of the lawsuit about the unconstitutionality of the family-head system(戶主制度) in the current Korean Family Law from the perspective of sociology of law. The lawsuit was filed in 2000 by the victims of the system with the support of lawyers and social movement organizations and the final decision in the Constitutional Court is now pending. This study tries to incorporate the divergence between the law and society through the examination of the relationship between the family-head(hoju) system and the changes in 'the families' in Korea. After delineating issues in the lawsuit, this paper reviews the nature of family-head system and the 'nuclear' family in Korean society. It then investigates if and how the 'family model' instituted in the family-head system could be realized in the current Korean families as revealed in the statistics in the national survey of the population and household. There are three focuses in this investigation: small￢family tendency (structural discrepancy); sex-ratio imbalance (realization); divorce and remarriage trends (oppression). As shown in this study, the system has been structurally discrepant from the current family trends and yet the influences of the family-head system are prevailing in the families in Korea. Thus, the judgement for this lawsuit need to be the criteria of 'public interests,' rather than that of 'private interests' of the individual victim families. This study points out indispensability of the sociological perspective for this lawsuit and suggests the abolishment of the system is not so much as the ending as the beginning of the new family relationship in Korea.
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닭 오브알부민 프로모터의 길이에 따른 유전자 발현 활성 및 에스트로겐 반응성 분석
양현,김경운,김점순,우제석,이휘철,최훈성,정선근,수레쉬쿠마,이해선,오건봉,변승준 한국가금학회 2019 韓國家禽學會誌 Vol.46 No.1
Chickens have been considered as well-defined animal bioreactor. The optimized ovalbumin promoter is essential for recombinant protein production in transgenic chicken. Here we try to compare the activity and identify the effect of estrogen on ovalbumin promoter according to each promoter length with estrogen response element (ERE) existence. We cloned two (2.8 and 5.5 kb) ovalbumin promoters that the 5.5 kb contained the ERE but the 2.8 kb did not, and these two promoters were cloned to pGL4.11 vector. Additionally, we constructed another pGL4.11 vector containing of the 4.4 kb (with ERE) ovalbumin promoter deleted with 1 kb between ERE region and the 2.8 kb promoter. For reporter assay, HeLa, MES-SA, LMH/2A, and cEF cells were transfected with all the pGL4.11 vectors. The comparative analysis showed that the mutated 4.4 kb promoter has more potent activity than the 2.8 and 5.5 kb promoters in HeLa, MES-SA, and LMH/2A cells. However, there is no significant difference in cEFs. Also, these cells transfected with the mutated 4.4 kb promoter were treated with the 17β -estradiol (0∼3,000 nM) and HeLa, MES-SA, and LMH/2A cells showed estrogen responsibilities, but cEFs did not. Besides, the mutated 4.4 kb promoter has still higher activity than the 2.8 and 5.5 kb promoter, and there is no transcriptional induction effect in 2.8 kb promoter at 500 nM estrogen that is blood concentration of laying hens. Hence our study strongly suggested that the mutated 4.4 kb promoter is considered as one of the most efficient length for generating transgenic chicken.
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