Differentiation of Osteoporotic Fracture from Metastatic Fracture in Spine using MRI

양준영,Ho Jin Lee,이준규,Jun Yeong Park,Byungkon Shin 대한골다공증학회 2012 Osteoporosis and Sarcopenia Vol.10 No.2

Objectives: To determine that compression fracture of L5 and posterior convexity of the vertebral body on MRI are useful indicators of spinal metastasis. Materials and Methods: Forty seven cases of vertebral compression fractures with magnetic resonance imaging (MRI) were reviewed. They were classified into two groups: the metastatic fracture (MF) group (n=23) and the osteoporotic fracture (OF) group (n=24). Each cases were evaluated according to their MRI findings of fracture site location, and the presence of posterior convexity of the vertebral body, intact midseptum and anterior signal change. Conventional T1 and T2 weighted images were obtained. Statistical analysis was done using the paired t-test and fisher’s exact test. Results: The MF group had 100% incidence of fracture in L5 (P<0.01). The incidence of positive posterior convexity was also 100%. The incidence of a positive anterior signal change was 67% (n=16) and intact septum was seen in 16 patients (67%). In the OF group, there were no fractures in L5 (16 cases with L1 fractures [67%]) and only 3 cases with posterior convexity (12.5%). Midseptum was intact in 19 cases (79%) and 6 patients with positive anterior signal change (25%). Conclusions: The location of vertebral fracture, especially in L5 and convex deformity of posterior vertebral body are reliable indicators of spinal metastasis.

한국 척수 및 마미 손상 환자의 다기관 공동 역학조사

양준영,심대무,김태균,문은수,손홍문,홍창화,나기호,차수민,주용범 대한척추외과학회 2011 대한척추외과학회지 Vol.18 No.3

Study Design: Multi-center study, questionnaire survey. Objectives: To offer a database of spinal cord injury (SCI) by reviewing statistics and literatures of other countries, investigating the overall mechanism, injury patterns and treatment of SCI. Summary of Literature Review: There are no preexisting domestic studies (collectively conducted by multi-centers) of the prevalence and treatment of SCI. Materials and Methods: From September 2006 to August 2009, 47 cases of SCI in 6 universities were investigated retrospectively. 17questionnaire contents including the courses of injury-to-treatment were studied with data gathered from surveys. Results: The average age of patients was 48.4-years-old, male to female ratio was 33 to 14. The cases of falling from a height were 22cases (47%), lumbar area 19 cases (40%), and unstable bursting fracture 24 cases (51%) the most. Complete and incomplete paralyses were 19 cases (40%) and 28 cases (60%), respectively. High dose steroids were injected in 16 cases (NASCIS II) and 9 cases (NASCIS III). 14 cases presented complications and operations were performed 46 cases (98%). 12 cases (26%) arrived at the hospital within 4 hours of injury, 11 cases (23%) in 8 hours. On the way to the hospital, proper emergency treatment was performed in 25 cases (53%), and 30cases (64%) had a clear understanding of SCI after the final diagnosis. Conclusions: This is the first study that offers a comprehensive database of spinal cord injury (SCI), by investigating the overall mechanism, injury patterns, and treatment of SCI; this study is expected to be used in the future as an important reference material for spinal cord injury statistics and a standard for care. Key Words: Spinal cord injury, Multi-center study, Prevalence

유전자 변화를 근거로 한 척수손상의 단계의 구분

양준영,이준호,이준규,주용범,차수민 대한척추외과학회 2011 대한척추외과학회지 Vol.18 No.3

Study Design: An experimental study. Objectives: To define the phases of chronic spinal cord injury by researching the changes in gene expression. Summary of the Literature Review: The exact time of conversion from acute stage to chronic stage in spinal cord injury is unknown. Materials and Methods: We used 18 month-old Beagle dogs as study subjects. Under spinal cord monitoring, we underwent laminectomy on thoracic vertebra 10 and 11, and induced cord injury by a weight-drop injury method. Dogs in each group with spinal cord injury and group without spinal cord injury on POD 1, 7, 30, and 90. The motor functions were evaluated using the Tarlov scale. Tissues were prepared from 0.5cm up and down from the 10th thoracic level. Additional cephalic and caudal lesions from the injured site were prepared. We have checked the differentially expressed gene(DEG). Results: The mean Tarlov value was 0.67 which indicated a significant cord injury. 4 DEG (GP3, 9, 25, 34) were detected among 40primers after screening, the detection percentage of which was 10. In the tissues of study subjects with spinal injury, DEG was found at the injury site and cephalic lesion. DEG expressed GP3, GP9 and GP34 started expression on day 30, and GP25 was expressed on day 90. Conclusions: According to the changes in gene expression, the day 30 would be considered as the date of conversion from acute to chronic phase of cord injury. Inhibiting secondary inflammatory change and apoptosis following spinal cord injury until this period would maximize the effect of chronic phase therapy such as cell-transplantation. Key Words: Spinal cord injury, Differentially expressed gene

Improvement of Adhesion between Fluorinated Polymer and Copper Films Using Ion Beam Treatment for FCCL

양준영,정성훈,변은연,최승회,김도근,김효정,이승훈 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1

시즈닝에 따른 아동용 고단백 스낵의 구매행동 및 소비자 기호도 연구

양준영,오혜인,장진아,오지은,강남이,조미숙 한국식생활문화학회 2018 한국식생활문화학회지 Vol.33 No.5

This study was conducted to evaluate children’s purchase behavior (frequency of snack consumption and purchase) and preference for high protein snack products developed for weight control and nutritional balance. A total of 80 elementary school students (from the 3rd to 6th graders) in the Gyeonggi-do learning center were participated and 76 were used for the analysis. The most common response for liking snacks was taste (71.4%), and the most preferred types of snacks were chips (42.1%) and puff snacks (34.2%). The highest frequency of snack ingestion was 1-3 times per week (48; 63.2%), and the main purchasers were parents (65.8%). Cheese, corn and chili flavors were more preferred than the control, while yogurt taste was slightly less preferred than the control. The results of this study showed the possibility of commercialization of new protein snacks according to children’s seasoning preference and provide the insights into the snack preferences of children as main consumers.

골다공증성 척추 골절에서 편측 부분 척추성형술의 임상 결과

양준영,이준규,차수민,주용범 대한척추외과학회 2011 대한척추외과학회지 Vol.18 No.2

Study Design: This is a prospective clinical study Objectives: We wanted to compare the clinical results of conventional vertebroplasty(VP) and the newly devised unilateral partial vertebroplasty(UPVP) . Summary of Literature Review: There has not been any study on how to reduce the amount of cement used while maintaining the height of the vertebral body and minimizing the adjacent compression fractures. Materials and Methods: From 2004 to 2008, Group 1 underwent VP and group 2 underwent UPVP. We compared the difference of the VAS score, the period of hospitalization, the infused amount of cement, the progression of the vertebral body collapse and fresh fracture of the adjacent vertebral body on the follow-up simple radiographs. Results: In group 1, the mean VAS score changed from 6.69 to 2.80, the mean period of hospitalization was 2.30 days and the mean amount of cement infused was 6.50cc. The degree of vertebral body collapse was 0.83, 0.76, 0.69 and 0.63 on follow-up, and 3 cases had fresh fracture. In group 2, the mean VAS score changed from 6.41 to 2.61, the mean period of hospitalization was 2.23 days and the mean amount of cement infused was 3.74cc. The degree of collapse was 0.71, 0.69, 0.68 and 0.63 on follow up and 1 case had fresh fracture. The two groups showed no statistical significance for the change of the VAS score and the period of hospitalization, and the amount of cement was significantly less in group 2. The degree of collapse was not significantly different on the 4 times of follow-up. The frequency of fresh fracture was significantly less in group 2. Conclusions: UPVP could achieve similar results for pain relief, the period of hospitalization and vertebral body collapse as compared to that of VP, but fresh fracture of the adjacent vertebral body was less. So, UPVP could be a better method than VP. Key Words: Unilateral pedicle, Osteoporotic Compression Fracture, Vertebroplasty, Unilateral Partial Vertebroplasty 연구 계획: 전향적 임상 연구목적: 골다공증성 척추 골절의 시멘트를 이용한 척추 성형술에서 전통적 척추 성형술과 편측 척추경을 통한 부분 척추 성형술과의 임상 결과를 비교하고자 하였다. 선행문헌의 요약: 척추체 높이를 유지하면서 인접 분절의 골절을 최소화 할 수 있는, 시멘트의 양을 줄일 수 있는 기존의 연구는 없었다. 대상 및 방법: 2004년부터 2008년까지 68예를 대상으로 하였다. 1군(35예)은 양측 척추경을 통해 척추 성형술을 시행하였고 2군(33예)은 편측 척추 성형술을 시행하였다. 시술 후 VAS 점수 변화의 정도, 입원 기간, 주입된 시멘트 양의 차이를 비교하였다. 시술 후 3개월, 9개월, 15개월, 24개월째 추시단순 방사선 사진에서의 추체 함몰의 진행 정도 및 인접 추체의 신생 골절 여부를 파악, 비교하였다. 결과: 1군의 VAS 점수는 평균 6.69에서 2.80로 감소되었으며, 입원 기간은 시술 후 평균 2.30일, 주입된 시멘트 양은 평균 6.50 cc였다. 추체 함몰의 정도는 추시 3개월, 9개월, 15개월, 24개월째 평균 0.83, 0.76, 0.69, 0.63였으며 신생 골절은 3예에서 존재하였다. 2군의 VAS 점수는 평균 6.41에서 2.61로, 입원 기간은 시술 후 평균 2.23일, 주입된 시멘트 양은 평균 3.74 cc였다. 추체 함몰의 정도는 추시 3개월, 9개월, 15개월, 24개월째 평균 0.71, 0.69,0.68, 0.63이었다. 신생 골절은 1예에서 존재하였다. VAS 점수의 변화 및 입원 기간은 두 군간에 유의한 차이는 없었으며, 주입된 시멘트 양은 2군에서유의하게 적었다. 함몰의 정도 역시 4번의 추시 계측상 유의한 차이는 없었다. 신생 골절의 빈도는 2군에서 유의하게 1군에 비해 적었다. 결론: 골다공증성 척추 압박 골절에서 편측 부분 척추 성형술은 전통적인 방법에 비해 더 적은 양의 골 시멘트를 주입하더라도 통증 완화 정도 및 입원기간, 추체 함몰의 진행에 있어서 통계학적 유의한 차이는 없었고, 인접 분절의 신생 골절 비율은 더 적게 나타나는 바, 양측 척추경을 통한 방법에 비해보다 우수한 방법으로 판단되는 바이다. 색인 단어: 편측 척추경, 골다공증성 척추 압박 골절, 척추 성형술, 편측 부분 척추 성형술약칭 제목: 편측 부분 척추성형술의 임상 결과

하이프로틴바(high protein bar)의 개발을 위한 소비자 인식 및 기호도 연구

양준영,오혜인,오지은,조미숙 한국식생활문화학회 2018 한국식생활문화학회학술대회논문집 Vol.2018 No.10

딥러닝 모델 adaptation 기술의 연구 동향

양준영,장준혁 한국통신학회 2016 정보와 통신 Vol.33 No.9

딥러닝 기술은 수많은 입력 데이터에 내재하고 있는 특징을 추출 및 합성함으로써 복잡한 특징공간을 모델링할 수 있는 강점을 가지지만, 테스트 환경에서 나타날 수 있는 특정 데이터 분포에 대하여 일반화가 잘 되지 않을 경우에는 해당 데이터를 이용하여 주어진 환경에 모델을 적응시킬 수 있는 기술을 필요로 한다. 이 글에서는 DNN 모델의 adaptation 기술 연구가 가장 활발하게 진행되고 있는 음향모델링에서의 다양한 adaptation 기술을 통해 연구 동향을 알아본다.

임상 결과를 근거로한 마미 증후군 환자의 예후 평가 점수 체계

양준영,이준규,송호섭,주용범,차수민 대한척추외과학회 2011 대한척추외과학회지 Vol.18 No.2

연구 계획: 후향적 연구목적: 마미 증후군의 임상증상을 이용한 평가 점수 체계를 만들고 예후 예측에 대한 유용성을 평가하였다. 선행문헌의 요약: 마미 증후군의 임상 결과를 예측할 만한 명확한 인자들에 대한 적절한 평가 점수 체계는 현재까지 알려져 있지 않다. 대상 및 방법: 1998년부터 2006년까지 마미 증후군으로 진단받고 2년 이상 추시가 가능하였던 21예를 대상으로 하였고, 추간판 탈출증 6예, 퇴행성척추병변 6예, 척추골절 7예, 전이성 척추종양 2예였다. 일반적으로 마미 증후군에 동반되는 임상 증상 중 요통, 좌골 신경통, 하지감각장애, 하지운동장애, 안장감각 소실, 배뇨장애, 항문 괄약근 수축력장애, 심부건반사장애를 이용하여 8가지로 평가 점수 체계를 만들었다(Scoring System for Cauda Equina Syndrome (SSCES)). 결과: 최종 추시결과 우수 3예, 양호 5예, 보통 5예, 불량 8예였다. 마미 증후군의 술전 점수는 평균 11.7 ± 2.8점(7-16점)이었고, 최종 추시상 점수는 평균 7.6± 3.4점(2-13점)이었다. 술전 SSCES 점수가 6점 이하인 8예는 최종 추시상 점수는 평균 3.9 ± 11점(2-5점)으로 임상결과가 양호하였으며 술전SSCES 점수가 7점 이상인 13예는 최종 추시상 점수가 평균 9.9 ± 1.9점(7-13점)으로 임상결과가 나쁜 경향을 보였다. 결론: 술전 환자의 SSCES가 낮을수록 최종 추시상 좋은 예후를 보이는 것을 확인할 수 있었다. 그러므로 마미 증후군 환자의 치료에 있어서 SSCES를이용한 술전 평가는 환자의 예후를 예측하는데 있어서 매우 유용한 것으로 사료된다. 색인 단어: 마미 증후군, 예후인자, 평가 체계약칭 제목: 마미 증후군 환자의 예후 평가 Study Design: This is a retrospective study Objectives: We made a scoring system using the symptoms of cauda equina syndrome(CES) and we studied the efficacy of the scoring system. Summary of the Literature Review: There has been no definite scoring system with clear factors that can predict the clinical results of cauda equine syndrome Materials and Methods: Between 1998 and 2006, 21 patients who were diagnosed with CES and who were followed for more than 2 years were enrolled in this study. There were 6 cases of HIVD, 6 cases of degenerative spondylosis, 7 cases of vertebral fracture and 2 cases of metastatic spinal tumor. We made a scoring system for CES (SSCES) using 8 symptoms among the general clinical manifestations that accompany CES, which are low back pain, sciatic neuropathy, sensory and motor disorder of the lower extremities,loss of a saddle sensation, voiding difficulty, disorder of the anal sphincter tone and deep tendon reflex disorder. Results: The last clinical outcomes were 3 excellent patients, 5 good patients, 5 fair patients and 8 poor patients. The mean preoperative SSCES was 11.7±2.8(7-16) and the mean final follow up score was 7.6±3.4(2-13). Eight cases that had a mean preoperative SSCES score of 6 or below showed good clinical results with a mean SSCES of 3.9±11(2-5) on the final follow up, and 13 cases with a mean preoperative SSCES score of 7 or above showed bad clinical results with a mean SSCES of 9.9±1.9(7-13) on the final follow up. Conclusions: The prognosis was better on the final follow up for the patients with a lowere preoperative SSCES. So, for the treatment of CES, preoperative evaluation using the SSCES is thought to be very useful for predicting the prognosis. Key Words: Cauda equina syndrome, Prognostic factor, Scoring system

연령대에 따른 근위 대퇴부 및 요추부 골밀도 검사의 상관관계

양준영,이준규,주용범,차수민,박준영 대한골다공증학회 2011 Osteoporosis and Sarcopenia Vol.9 No.3

Objectives: To analogize the test results through analyzing the correlation of bone mineral density (BMD) values between 2 sites (proximal femur and lumbar spine). Materials and Methods: Among the 1557 cases that underwent BMD test on their proximal femur and lumbar spine without history of trauma or disease of the hip or lumbar region, according to their age, they were divided into 4 groups, and the T-score and Z-score of the proximal femur and lumbar spine were each investigated. Results: The correlation figured out through the regression analysis was that, considering the lumbar spine value as the independent variable (L), and the proximal femur value as the dependant variable (H), the T-score was H=0.508×L-0.723 in group 1, H=0.445×L-0.649 in group 2, H=0.363×L-1.124 in group 3 and H=0.404×L-1.467 in group 4. The correlation coefficient of T-score value of the 2 sites of each group was 0.58, 0.59, 0.47, 0.54 each, and which were statistically significant. Z-score was H=0.485xL-0.514 in group 1, H=0.451×L-0.141 in group 2, H=0.390×L-0.401 in group3, L=0.897×H-0.481 in group 4. Conclusion: On the BMD test performed in an age group of over 40 years old, T-score and Z-score each showed significant increase and this is thought to be related to low bone mineral due to bone mineral decrease because of the old age. Also, in cases with lesion in the hip joint or spine, there is a clinical usefulness of analogizing the result of the other region with a result of a single region.