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입원 환자의 섬망 치료에서 멜라토닌의 효과에 관한 후향적 연구
양정우,김종우,강원섭,이상민,김영종,백종우 한국정신신체의학회 2018 정신신체의학 Vol.26 No.2
Objectives:Delirium is one of the most common mental illnesses that can affect cognitive function. Melatonin has been shown to be effective in the treatment of insomnia, and recent studies have shown a protective effect to prevent delirium. This study was conducted to investigate the efficacy of melatonin in delirium patients. Methods:All patients were referred to psychiatric department for insomnia and symptoms of delirium, and were diagnosed delirium by the DSM-5 diagnostic criteria. We compared base line severity of delirium with KDRS- R-98-R (Korean version of Delirium Rating Scale revised 98) and after taking 2mg of melatonin, retrospectively. The side effects were also identified by referring to the medical records. Results:A total 21 patients had taken melatonin for insomnia and delirious symptoms. The K-DRS-R-98 scores were decreased from 15.24±2.64 before treatment to 6.57±5.42 after treatment. And CGI-S scores were also decreased from 4.14±0.48 before treatment to 2.81±0.93 after treatment (p<0.05). Conclusions:This study illustrates the possibility of melatonin as an effective treatment option for delirious symptoms such as disorientation, motor agitation, lability of affect and hallucinations as well as insomnia, with less concerns of drug side effect. Further study with a larger sample and prospective design will be required to confirm these results. 연구목적: 섬망은 신체 질환과 같은 기저 의학적 상태의 변화에 의해 나타나는 뇌의 기능장애로 환자의 사망률을 높이고 치매의 위험도를 높이는 등 불량한 예후와 연관되어 있다. 기존 섬망의 치료에 주로 사용된 항정신병약제는치료 효과에 대한 논란이 있으며 추체외로 부작용 등에 대한 우려가 있다. 따라서 수면 주기 조절 및 섬망 예방효과가 있는 것으로 알려진 멜라토닌 투여를 통해 섬망 호전 정도와 안전성을 조사하고자 하였다. 방 법: 불면을 동반한 섬망 증상으로 정신건강의학과에 진료 의뢰되어 멜라토닌 2mg을 투여 받은 환자를 대상으로 의무기록을 통해 섬망 증상의 초기 중증도 및 멜라토닌 투여 후의 섬망 증상 변화 여부를 한국판 섬망 평가척도-98 개정판(K-DRS-R-98)과 CGI-S를 통해 확인하였으며 부작용을 검토하였다. 결 과: 총 21명의 환자가 불면을 동반한 섬망 증상으로 멜라토닌을 투여받았다. K-DRS-R-98 심각도 점수는 투약전 15.24±2.64에서 투약 후 6.57±5.42로 감소하였으며 CGI-S 점수는 4.14±0.48에서 2.81±0.93로 감소하였다(p<0.05). 의무기록 상 부작용은 관찰되지 않았다. 결 론: 약물의 기전 상 추체외로 증상과 QTc연장 등의 문제를 유발하지 않는 멜라토닌의 사용은 보다 안정성을
양정우,채승아,Minjee Lee,Won Yeong Bang 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.4
In the previous study, we isolated Bacillus coagulans IDCC 1201 from green malt and found that it was safe for use as a probiotic, based on phenotypic and genomic analysis. In the present study, we investigated the anti-inflammatory and antibacterial activity using the cell-free lysate of this strain since the two properties can be its additional advantages as a probiotic. The following results were obtained: 1) In the RAW 264.7 (a mouse macrophage cell line) treated with lipopolysaccharide, the lysate of this strain inhibited the decrease of cell viability, the increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the increased expressions of inducible NO synthase (iNOS) (a NO producer), inducible cyclooxygenase-2 (a PGE2 producer) and proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6. 2) The lysate also inhibited the growth of five pathogens such as Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella Typhimurium, and Streptococcus pneumoniae. These two properties obtained provide B. coagulans IDCC 1201 with merits for a probiotic that can be of help particularly to the bowel in the inflammatory condition. Thus, it is thought to be worth developing this strain as a health supplement for this purpose. In the previous study, we isolated Bacillus coagulans IDCC 1201 from green malt and found that it was safe for use as a probiotic, based on phenotypic and genomic analysis. In the present study, we investigated the anti-inflammatory and antibacterial activity using the cell-free lysate of this strain since the two properties can be its additional advantages as a probiotic. The following results were obtained: 1) In the RAW 264.7 (a mouse macrophage cell line) treated with lipopolysaccharide, the lysate of this strain inhibited the decrease of cell viability, the increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the increased expressions of inducible NO synthase (iNOS) (a NO producer), inducible cyclooxygenase-2 (a PGE2 producer) and proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6. 2) The lysate also inhibited the growth of five pathogens such as Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella Typhimurium, and Streptococcus pneumoniae. These two properties obtained provide B. coagulans IDCC 1201 with merits for a probiotic that can be of help particularly to the bowel in the inflammatory condition. Thus, it is thought to be worth developing this strain as a health supplement for this purpose.
Phonon spectra of clean and Ni-terminated diamond (111) surfaces: An ab-initio study
양정우,박종환,변민교,황농문,박진우,유병덕 한국물리학회 2021 Current Applied Physics Vol.21 No.-
The phonon densities of states (ph-DOSs) of clean and Ni-terminated C(111) surfaces with 1 × 1 and 2 × 1 surface structures were investigated using ab-initio density functional perturbation theory. The ph-DOSs showed vibrational spectra associated with the surface structures of C(111) and Ni/C(111). Further analyses of various surface phonon modes were performed to identify vibrational features involving the surface atoms of C(111) and Ni/C(111). These features provide important information for experimentally verifying the formation of a diamond bulk-like structure at Ni/C(111), as suggested in a previous study.