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백일해 백신이 Streptozotocin 유발성 당뇨백서의 당대사에 미치는 영향
박상기,문경래,박춘호,김갑승,박영봉,이병래,양남웅 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
Streptozotocin(STZ) may produce a permanent form of insulin-dependent diabetes (IDD) in experimental animals. This STZ-induced diabetes has become an useful model to study the pathogenesis of IDD in man primarily because it approximate clinical findings and also because it lends itself easily to controlled manipulation. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and pertussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine(bPV; incubating the PV at 80℃ for 30 minutes) against the development of IDD induced by STZ in young rats, and also the effect of PV on the activities of glycolytic & gluconeogeneic enzymes in both liver and muscle of rat. PV at a dose of 1.2×10^(10) microorganism was administrated intrapntoneally on 3days before & 7days after a single injection of STZ (GO㎎/㎏ body wt). The blood glucose and insulin levels were measured at 1st wk, 2nd wk, 4th wk, 6th wk and 8th wk after STZ injection, and the enzyme activities were exemined at 8th wk. The following results were obtained. 1. No significant difference was noted in blood glucose levels between STZ group and STZ+PV or STZ+bPV groups (P>0.05). 2. Blood insulin levels in STZ group decreased significantly from 2nd wk(P<0.05). Compared with STZ group, blood insulin levels in STZ+PV & STZ+bPV groups were higher, but not a significant value except at 2nd wk in STZ+PV grouP (P<0.05). 3. Compared with STZ group, hepatic glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups, and muscular glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. 4. Compared with STZ group, hepatic gluconeogeneic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. These results suggest that the PV has somewhat protective effects on blood insulin levels and tissue glycolytic enzyme activities in rats, but it could not reduced blood glucose levels significantly, probably because of excessive increase of hepatic gluconeogeneic enzymes.
Nocardia Otitidiscaviarum에 의한 피하농양 1예
양남웅,이현국,박정평,박영진,문대수,장숙진 대한감염학회 1991 감염 Vol.23 No.2
A 61-year-old-Korean woman suffering from hypopituitarism accompanied by thyroid insufficiency, adrenal insufficiency, Diabetes mellitus was examined for subcutaneous abscess on her left inner thigh. The causative organism was identified as Nocardia otitidiscaviarum. To our knowledge, the present case in the first known Korean case of primary cutaneous nocardiosis caused by Nocardia otitidiscaviarum.
Staphylococcus aureus에 대한 Rifampin과 Quinolone의 항균효과 및 병합효과
임용,양남웅 中央醫學社 1990 中央醫學 Vol.55 No.7
Methicillin susceptibility test for 29 strains of Staphylococcus aureus isolated from clinical specimens was done by oxacillin disc diffusion method. In the test, methicillin-resistant-Staphylococc. is aureus (MRSA) and Methicillin-susceptible-Staphylococcus aureus (MSSA) were 19 (65 %) and 9 (31 %) strains, respectively. MICs (minimal inhibitory concentration) to rifampin, nalidixic acid, pipemidic acid, ciprofloxacin, enoxacin, ofloxacin, and norfloxacin were tested against MRSA and MSSA. (Table 1, 2). As results of antibiotic combination tests of Rp + Na, RP + Pa, Rp + Cx, and Na + Pa, Rp + Cx and Rp + Pa exhibited relatively high antagonism. But, in the. case of RP + Na, all strains of MSSA did not show any antagonism against this combination. Combination of Na + Pa exhibited one antagonistic strain of MRSA and MSSA each.
녹농균의 quinolone제재에 대한 감수성 및 혈청형 분포
최승호,고한철,이현국,박정평,임용,양남웅,김학렬,박열 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
123 strains of Pseudomonas aeruginosa isolated from various clinical specimens were tested for the distrution of serotypes and the evaluation of the antimicrobial susceptibility to each generation quinolone impounds. The results were as follows : 1. 107 strains(87%) were typable out of clinical isolate 123 strains. Serotype G was prevalent with 33 strains (26.8%) and followed by serotype E, 31 strains (25.2%), serotype B, 15 strains (12.2%) and successively typed in the order of serotype A, C, D, F, H, I, L, M, but serotype J,K and N were not entirely typed. 2. MIC peak was 1024ug/ml in case of nalidixic acid, 32ug/ml in pipemidic acid, 0.25ug/ml in ciprofloxacin, 2ug / ml in ofloxacin. 2ug/ml in enoxacin. 0.5ug/ml in norfloxacin, finally 8ug/ml in rosoxacin. 3. The second generation quinolone compound, pipemidic acid exhibited 8 to 30 times higher activity to Pseudomonas aeruyrtcisa than the first generation quinlolne, nalidixic acid. And the third generation compounds showed 4 to 100 times higher activities than the second generation quinolone. Especially ciprofloxacin showed 2 to 30 times higher antimicrobial activity than other generation quinolone compounds. 4. There were no significant differences to susceptibility patterns among the serotypes.
녹농균의 항균제 내성양상 및 Rifampin과 Quinolone제와의 병합효과
박정평,고한철,나영천,임용,이현국,양남웅,박열 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Clinically isolated 92 strains of Pseudomonas aeruginosa were serotyped and their resistance patterns to total 24 kinds of antimicrobial agents (i.e., Penicillins, aminoglycosides, cephalosporins, quinolones) were studied by MIC(minimal inhibitory concentration). In addition, serotype G(16 strains) and E(16 strains), which isolated with high frequency in clinical field, were used for a study about combined effects of quinolones and rifampin by the checkerboard method. These drugs are being spotlighted as therapeutics of Pseudomonas aeruginosa infections. The results were as follows; Serotypable strains of Pseudomonas aeruginosa were 87 strains(94.6%) out of 92 strains clinically isolated. In these strains, G types were isolated in largest numbers(28 strains, 30.4%), E types were 25 strains (27.2%), B types 12 strains (13.0%), the other types were less than 7% and J,K,N types were not typed at all. In the MIC peak of each antibiotics, ciprofloxacin showed lowest peak as 0.25㎍/㎖, another third generation quinolones also showed low MIC peaks of 8㎍/㎖ and less. Amikacin, the aminoglycosides, and rifampin revealed MIC as low as 32㎍/㎖ relatively, but the others did not. MIC of gentamicin, tobramycin, nalidixic acid, rifampin, piperacillin and amikacin were distributed in a wide range of 0.5㎍/㎖ to >512㎍/㎖, but in MIC_(50) of all above antibiotics were 256㎍/㎖ or more, and MIC_(90) were above 512㎍/㎖, the third generation quinolones except rosoxacin showed very low MIC ranges less than 64㎍/㎖, and revealed good antimicrobial activities as seen in that MIC_(50) were less than 2㎍/㎖ and MIC_(90) were below 8㎍/㎖. On seeing MIC ranges according to serotypes, in most antibiotics, E types were slightly resistant than G types but there are no much differences. In combinations of rifampin and quinolones, rifampin-enoxacin combination revealed relatively as good synergistic effect as 37.5%(12 strains), rifampin-nalidixic acid showed 34.4%(11 strains), and the other combinations also showed good results comparatively. In addition, rifampin-ciprofloxacin had antagonistic effect of 31.3%(10 strains). But on the whole, it can be said that these combinations have much affirmative significance in antibiotic therapy to Pseudomonas aeruginosa. According to the serotypes, synergism of rifampin-nalidixic acid to G types was zero%(0 strain) and 31.3%(5 strains) to E types. All combinations except rifampin-nalidixic acid revealed high synergistic effects to E types and in proportion to this, antagonistic effects were low. This high synergistic effects to E types were in a contrast to slightly high resistance patterns of E types.