1P-220 Blue Emitter을 기반으로 한 Aromatic polymer의 합성과 발광 특성

양가람,이하윤,박종욱 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.0

Effect of Snake Venom Toxin from Vipera lebetina turanica on Breast Cancer Cells

양가람,송호섭 대한침구의학회 2009 대한침구의학회지 Vol.26 No.3

목적 : 이 연구는 Vipera lebetina turanica의 蛇毒藥鍼液(Snake venom toxin, SVT)이 인간 유방암 세포주인 MCF-7과 MDA-MB-231 세포에서 암세포성장의 억제 및 그 기전에 대하여 살펴보고자 하였다. 방법 : SVT를 처리한 후 MCF-7과 MDA-MB-231의 성장억제를 관찰하기 위해 CCK-8 assay를 시행하였고, apoptosis 평가에는 TUNEL assay를 시행하였다. 세포자멸사 관련 세포기전을 보기 위하여 세포내 활성산소량 및 미토콘드리아의 세포막전위 변화를 측정하였고, 세포자멸사 조절 단백인 Bax, Bcl-2 발현 변화 관찰에는 western blot analysis를 시행하였다. 결과 : MCF-7과 MDA-MB-231 세포에 SVT를 처리한 후, 유방암 세포의 성장, Apoptosis의 유발 및 기전에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. MCF-7 세포와 MDA-MB-231 세포에서 SVT를 처리한 후 유방암 세포 성장이 억제되었다. 2. TUNEL assay를 통한 세포자멸사 평가에서 SVT를 처리한 MCF-7세포와 MDA-MB-231 세포 모두 세포자멸사 활성세포의 유의한 증가를 나타내었다. 3. 세포자멸사 관련 세포기전연구에서 SVT를 처리한 MCF-7 세포와 MDA-MB-231 세포에서 세포내 활성산소의 유의한 증가와 미토콘드리아 세포막 전위의 유의한 변동이 관찰되었다. 4. SVT를 처리한 MCF-7세포와 MDA-MB-231세포는 세포자멸사 관련 단백 발현에서 Bax의 유의한 증가와 Bcl-2의 유의한 감소를 나타내었다. 결론 : 이상의 결과는 SVT가 세포내 활성산소를 증가시킴으로써 미토콘드리아의 세포막전위에 변화를 일으켜 유방암 세포주인 MCF-7과 MDA-MB-231 세포에 세포자멸사를 유발하여 증식억제 효과가 있음을 입증한 것이다.

항공 전투 시뮬레이션의 합성전장환경 구축을 위한 환경 데이터 관리 및 공급 방안

양가람,함원경,박상철,Yang, Ka-Ram,Hwam, Won K.,Park, Sang C. 한국시뮬레이션학회 2013 한국시뮬레이션학회 논문지 Vol.22 No.3

본 논문에서는 항공전장 환경의 구축을 통한 항공 무기체계의 가상시험에 환경적 영향을 반영하여 모의할 수 있도록 환경데이터를 제공하기 위한 내용을 수행하였다. 항공 전투 시뮬레이션에서 전투 개체들이 모의하는 작전은 환경 영향에 의하여 그 달성 결과가 달라져야 한다. 본 연구에서는 항공 전투 시뮬레이션 시스템에 합성전장환경 구축을 위해, 실제 항공 전장환경을 분석하여 합성전장환경을 설계한다. 설계한 합성전장환경의 구현을 위해 적합한 실제 환경 데이터를 수집하고, 수집된 환경데이터를 기반으로 합성전장환경 구축을 위해 공간 보간법(GIS, Geographic information system interpolation)을 활용하여 데이터를 가공한다. 본 논문의 최종 목적은 항공 전투 시뮬레이션에 환경 영향을 반영하기 위해 대기 환경 속성의 스펙트럼 중 시뮬레이션에서 요구하는 속성을 도출하여 합성전장환경을 설계하고, 실제 대기 데이터를 기반으로 설계된 합성전장환경을 구현한다. 구현된 합성전장환경을 분산 시뮬레이션 시스템에서 환경 데이터 요구에 대해 전장환경 데이터를 제공하여 시뮬레이션 시스템이 실제 환경 데이터에 기반한 합성전장환경을 시뮬레이션에 반영할 수 있게 한다. In this paper, there is a research for providing environmental data to reflect environmental effects to the simulation for the aviation weapon systems by the construction of the synthetic battlefield. The results of the aviation engagement simulation are able to differ by environmental effect. This paper analyzes the real aviation battlefield and designs the synthetic battlefield based on the analysis. In order to construct the designed synthetic battlefield, we collects the real environmental data for the atmosphere and structures the collected data using GIS (Geographic information system interpolation). The main objective of this paper is to design the synthetic battlefield based on the derived environmental factors from the analysis of the real aviation battlefield, and it constructs the designed synthetic battlefield by the collection of real atmosphere data. The constructed synthetic battlefield provides the environmental data which are requested from the distributed simulation system, and it makes the system reflect environmental effects to the simulation.

Poly(9-(3-vinyl-phenyl)-phenanthrene)의 합성과 발광 특성

양가람,박종욱 한국고분자학회 2014 한국고분자학회 학술대회 연구논문 초록집 Vol.2014 No.4

Backward planning을 이용한 Bottleneck detection

양가람,안의국,정용호,장대순,김병희,서정철,박상철 대한산업공학회 2013 대한산업공학회 춘계학술대회논문집 Vol.2013 No.5

퇴행성슬관절염에 대한 봉약침과 온침효과 비교

양가람,송호섭,Yang, Ka-Ram,Song, Ho-Sueb KOREAN PHARMACOPUNCTURE INSTITUTE 2008 Journal of pharmacopuncture Vol.11 No.2

Objective This study was performed to investigate whether Bee Venom Pharmacopuncture(BVP) could be a more effective modality than Warm Needling(WN) in relieving pain and symptoms of knee osteoarthritis(OA). Design Prospective, randomized and controlled clinical trial. Setting Single center trial in Korea Patients 49 volunteers with knee OA participated in the study. All the participants were screened through an inclusion and exclusion criteria. 33 participants were completed the clinical trial. Intervention The subjects were randomly assigned to one of two groups. One group received BVP(n=18), while the other group received WN(n=15). Sixteen sessions of BVP or WN were given at the pain region of the problematic knee for 8 weeks. Primary outcome measure is the Korean translation of Western Ontario and McMaster Universities Osteoarthritis Index scores(Korean WOMAC, KWOMAC). Secondary outcome measure is the physical health scores based on the 36-Item Short-Form Health Survey(SF-36) and Patient Global Assessment(PGA). KWOMAC and SF-36 were measured third (baseline, 4 and 8 weeks). PGA was measured twice(4 and 8 weeks). Results BVP group showed significant decrease compared to WN group in pain, function and total scores of KWOMAC according to the Mann-Whitney U-test. In the PGA, BVP group, compared to WN group, showed a significant increase. Conclusions BVP was more effective in relieving pain of knee OA than WN. These findings suggest that BVP is a promising alternative for treating knee OA.

味覺障碍가 末梢性顔面神經麻痺의 예후에 미치는 영향

양가람,송호섭 대한침구의학회 2007 대한침구의학회지 Vol.24 No.3

Objectives : This study was to evaluate the influence of dysgeusia on prognosis of peripheral facial paralysis. Methods : We investigated 40 cases of patients with Peripheral Facial Paralysis, and classified them as existence of dysgeusia. we evaluated the treatment effect of each group by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System before treatment and after final treatment. Results : 1. Postauricular pain showed the highest frequency in symptoms at onset. 2. As a result of evaluation by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System, treatment score after final treatment was marked higher than that before treatment within each group. 3. After final treatment, non-dysgeusia group showed signficant difference on Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System compared with dysgeusia group. Conclusions : These results suggested that non-dysgeusia group should be get better than dysgeusia group in the patient with peripheral facial paralysis.

말초성안면신경마비에 대한 봉약침 복합치료

양가람,송호섭 대한침구의학회 2009 대한침구의학회지 Vol.26 No.4

Objectives : This study was to investigate the effectiveness of Bee Venom Pharmacopuncture complex therapy on peripheral facial paralysis. Methods : We investigated 30 cases of patients with Peripheral Facial Paralysis, and devided patients into two groups : We treated one group by complex oriental medical treatment with Bee Venom Pharmacopuncture therapy, and did the other group by complex oriental medical treatment without Bee Venom pharmacopuncture therapy. To investigate the effectiveness of treatment applied for two groups, we used Gross Grading System of House-Brackmann, Yanagihara’s Unweighed Grading System at baseline, 3 weeks and final. Results : 1. Male, Female is same ratio in distribution of sex, the number of left side is more than that of right side in distribution of lesion, the average age is 49.33. 2. Pain back of the ear showed the highest frequency among Bell’s palsy related symptoms at onset, the overwork was a major cause of Bell’s palsy in distribution of cause. 3. As a result of evaluation by using Gross Grading System of House-Brackmann, Yanagihara’s Unweighed Grading System, treatment score after 3weeks was marked higher than that before treatment and treatment score after final treatment was also marked higher than that after 3weeks within each group. 4. After final treatment, Bee Venom Pharmacopuncture therapy group showed signficant difference on Gross Grading System of House-Brackmann, Yanagihara’s Unweighed Grading System compared with Acupuncture therapy group. Conclusions : Bee Venom Pharmacopuncture therapy can be available for relieving symptoms related with peripheral facial paralysis.

Synthesis and luminescent properties of poly (9-(3-vinyl-phenyl)-phenanthrene)

양가람,이하윤,신환규,이재현,정효철,강석우,이수지,박종욱 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1

Recently, interest of polymer light-emitting diode (PLED) fabricated from conjugated polymer has augmented because PLED has advantage property that is well-suited to flexible lighting and solution processed device. In this presentation, we suggest a new polymer host based on phenanthrene, poly(9-(3-Vinyl-phenyl)-phenanthrene) (PVPP). It can be easily synthesized through simple synthetic methods which are Suzuki and Wittig reactions. From NMR data, vinyl group protons were disappeared and aromatic protons showed broad proton peaks because of polymer characteristics. PVPP film can be obtained from spin coating with solution used by common solvent. It exhibited PL maximum value of 381nm and broad PL spectrum of 70nm FWHM value. Energy transfer smoothly occurred when the three dopants for green, red and yellow were used in PVPP.

Heterogeneous 촉매를 적용한 Hiyama coupling 반응 연구

양가람,진선철,김신영,엄기원,정유진,송광호,이선우,배고운 한국공업화학회 2009 한국공업화학회 연구논문 초록집 Vol.2009 No.1