춘계학술대회 : 지상발표부 ; 의화의대 : Malignant Angioendothelioma 1예

안화영,함정희 대한피부과학회 1983 대한피부과학회 학술발표대회집 Vol.35 No.1

갑상선호르몬이 ATP-binding Cassette Sterol Transporter ABCG5의 발현에 미치는 영향

안화영,장진미,이관재,김순희,김경원,박도준,장학철,박영주 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.1

Background and Objectives: Excretion of bile acid and free cholesterol of bile was important to maintain cholesterol homeostasis. ATP-binding cassette transporter G5 (ABCG5) and G8 (ABCG8) promoted biliary cholesterol excretion. In previous study, hepatic secretion of cholesterol and ABCG5/G8 expression are strongly stimulated in hypophysectomized rats during treatment with thyroid hormone. In this study, we aimed to evaluate the effect of thyroid hormone to expression of ABCG5 and G8 in mouse liver. Materials and Methods:We administered thyroid hormone (T3) to C57BL/6 mice and then RNA and protein was isolated from liver. We isolated primary hepatocyte and administered T3 to evaluate in vitro effect. HepG2 cells were cotransfected with either a control plasmid or expression plasmids for human thyroid hormone receptor (hTR)β/human retinoid X receptor (hRXR)α or human liver X receptor (hLXR)α in combination with reporter plasmids TK-LXRE3-LUC with or without T3. Results: Serum total cholesterol was decreased after 5 days of T3 treatment. Expression of ABCG5/8 mRNA and ABCG5 protein was increased after T3 treatment. In primary hepatocytes, T3 also increased ABCG5/8 mRNA expression. LXRα mRNA was not increased by T3. However, when we cotransfected liver X receptor response element (LXRE) construct and TRβ/RXRα with T3, the activity of LXRE containing construct was markedly increased. Conclusion: We confirmed that thyroid hormone increased expression of ABCG5/8. This result suggested that thyroid hormone played an important role in decreasing serum cholesterol through bile excretion.

추계학술대회 : 구연부 ; H1 및 H2 수용체 차단제와 β2 아드레날린성 수용체 흥분제가 피부 히스타민반응에 미치는 영향에 관한 연구

안화영,명기범,국홍일 대한피부과학회 1983 대한피부과학회 학술발표대회집 Vol.35 No.2

갑상선호르몬이 담즙수송체인 Bile Salt Export Pump 발현에 미치는 영향

안화영,이관재,김순희,김은기,강아름,임정아,윤지완,김경원,박도준,조보연,박영주 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.3

Background: Bile acids were important for the regulation of cholesterol homeostasis. Thyroid hormone increased the expression of CYP7A1 (cholesterol 7α-hydroxylase), catalyzing the first step in the biosynthesis of bile acids. However, the effect of thyroid hormone on bile acid export has not been previously assessed. The principal objective of this study is to evaluate the effects of thyroid hormone on the bile salt export pump (BSEP). Methods: Thyroid hormone, T3 (1 mg/g) was administered to male mice via intraperitoneal injection. After 6 hours and 5 days of T3treatment, we measured serum total and LDL cholesterol and hepatobiliary bile acid concentrations. We assessed the changes associated with bile acid synthesis and transport. In order to evaluate the direct effect of thyroid hormone, we assessed the changes in the levels of BSEP protein after T3 administration in human hepatoma cells. Results: Serum total and LDL cholesterol were reduced and hepatobiliary bile acid concentrations were increased following T3treatment. Expressions of Cyp7a1 and BSEP mRNA were increased following T3 treatment. The levels of the BSEP protein in the mouse liver as well as in the human hepatoma cells were increased after T3 treatment.Conclusion: Thyroid hormone can regulate LDL cholesterol metabolism. It increases bile acid synthesis and the excretion of bile acids via increased BSEP expression.

다발성 Bowen병

안화영,함정희 임상약학사 1989 臨床藥學 Vol.9 No.11

Changes of Nodular Size and Its Risk Factors in Iodine-Sufficient Area: a Retrospective Cohort Analysis of 7753 Thyroid Nodules

안화영,김경원,최훈성,문재훈,이가희,현민경,강민주,심정임,이자연,박도준,박영주 대한갑상선학회 2020 International Journal of Thyroidology Vol.13 No.2

Background and Objectives: Iodine is known to be an important factor in the occurrence of goiter, and SouthKorea is a region with sufficient iodine supplementation. In this regard, we checked the size change of thyroidnodules found by health check-up in Koreans and examined which risk factors influence the size change. Materialsand Methods: A total 7753 subjects who underwent thyroid sonography two or more times were included. Wedefined that there was a change in the size of the nodule when the difference in diameter identified in the lastultrasound was more than 3 mm. Results: Thyroid nodules were decreased in 895 subjects (11.5%) and increasedin 1041 subjects (13.5%). The rate of increased nodule was on an increasing trend according to the duration(annual percent change 2.6%, p<0.001). In contrast, the rate of decreased nodule was unchanged. Predictivefactors related to decrease of the nodule size were young age, male sex, larger initial nodule size and thyroiditis. Similarly, young age, larger initial nodule size and diffuse parenchymal abnormality were significant predictivefactors for increased nodules. However, diffuse parenchymal abnormality was not a predictive factor when weanalyzed only thyroid nodules larger than 1 cm. Conclusion: In our study, 11.5-13.5% of benign thyroid noduleswere increased or decreased during median 27 months of follow-up in iodine sufficient condition. Young age,larger initial size and diffuse parenchymal abnormality were common predictive factor affecting both the increaseand decrease of thyroid nodules.

Six-Box Model을 이용한 일개대학 부속 한방병원의 조직진단과 직무만족, 조직몰입에 미치는 영향

안화영,권성복 보건의료산업학회 2018 보건의료산업학회지 Vol.12 No.1

Objectives : The purpose of this study was to present basic data on organizational changes in a Korean medicine hospital by performing organizational diagnosis and examining the job satisfaction and organizational commitment of the hospital. Methods : The subjects were a total of 218 employees in four Korean medicine hospitals, and data were collected from 1st to 25th September 2015. Using SPSS 21.0, frequency analysis, technical statistical analysis, t-test, ANOVA, Pearson’s correlation analysis, and multiple regression analysis were performed. Results : The Korean medicine hospital tended to value relationships, the rewards for and attitudes towards change were low. The number of participants in this study with higher organizational diagnosis scores was high for job satisfaction and organizational commitment, and there was a strong positive correlation. It was seen that rewards, relationship, helpful mechanisms, and leadership among organizational diagnosis areas had an effect on job satisfaction, and helpful mechanisms, purposes, and leadership had an effect on organizational commitment. Conclusions : These findings will be useful because policies, research, and education are needed to facilitate organizational changes in Korean medicine hospitals.

Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation

안화영,정경천,박도준,박영주,조보연 대한갑상선학회 2017 International Journal of Thyroidology Vol.10 No.2

Background and Objectives: Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with anaplastic foci. Materials and Methods: Eighteen patients with DTC with anaplastic foci were enrolled in this study. To compare the clinicopathologic characteristics and prognosis of anaplastic foci subjects with conventional ATC or DTC, we additionally included 12 ATC and 1030 DTC patients who diagnosed during same period. Immunohistochemistry was performed to check the gene expression in anaplastic foci and DTC component. Results: In anaplastic foci group, tumor size was larger (2.5±1.3 vs. 1.2±0.9 cm, p=0.001), distant metastasis was more frequent (11.1 vs. 0%, p=0.000) and 1-year survival rate was low (88.9 vs. 100%, p=0.000) than DTC group. In contrast, compared with ATC group, anaplastic foci group showed younger age at diagnosis (50±16 vs. 63±18 years, p=0.039), smaller tumor size (2.5±1.3 vs. 3.8±1.4 cm, p=0.027), less distant metastasis (11.1 vs. 41.7%, p=0.084) and longer 1-year survival rate (88.9 vs. 25.0%, p=0.001). Expression of p53 protein was observed in 100% of anaplastic foci, ATC and 12.5% of papillary thyroid carcinoma component. Conclusion: DTC with foci of anaplastic transformation has a worse prognosis than DTC, but a better prognosis than ATC. Our results support that DTC with anaplastic foci was intermediate state from DTC to ATC.

비만과 갑상선결절의 역학

안화영 대한갑상선학회 2017 International Journal of Thyroidology Vol.10 No.1

Recently, the incidence of thyroid nodule has been rising due to the usage of ultrasonography in health check-up. Also, modern society is faced with increasing rates of obesity by sedentary life style and high caloric intake. Obesity is closely related to metabolic syndrome and insulin resistance. Insulin resistance leads to hyperinsulinemia, increased insulin-like growth factor 1 and alteration of adipocytokine level. These factors not only have a role in metabolic regulation, but they also have mitogenic effect in cell proliferation. Epidemiologic and clinical evidence about the association between obesity and thyroid nodule are reviewed in this section.

수종 화장품의 자극성, 알레르기성, 광알레르기성, 광독성에 관한 연구

안화영,류경옥,조미형,명기범,국홍일 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.4

Each year a number of consumers experience some type of adverse reaction to cosmetic products. So it is important to recognize the reactions from cosmetics that may be of a general nature and to determine the causative agents in the formulation. In the present study, we performed patch test and photopatch test for the determination of irritancy, allergenicity, photoallergenicity, and phototoxicity of several cosmetics composed of usual cosmetic ingredients. The results of the study which were performed in 100 volunteers with six cosmetics and one perfume are as follows;1) The patch tests for irritancy and allergenicity of cosmetic were negative in 100 volunteers. 2) The photopatch test using perfume(0.3%) revealed positive response in one of 100 volunteers.