비당뇨병성 말기신부전 환자에서 심혈관질환 발생의 예측 인자로서 아디포넥틴의 유용성

안혜림 ( Hye Rim An ),문성진 ( Sung Jin Moon ),박형천 ( Hyeong Cheon Park ),이용규 ( Yong Kyu Lee ),김좌경 ( Jwa Kyung Kim ),김범석 ( Beom Seok Kim ),김형종 ( Hyung Jong Kim ),한대석 ( Dae Suk Han ),하성규 ( Sung Kyu Ha ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4

Purpose: Adiponectin (ADPN) has been known to protect against cardiovascular disease (CVD) in metabolic syndrome with normal renal function for its anti-inflammatory and anti-atherogenic property. However, it is still unclear whether ADPN is associated with cardiovascular outcomes in end-stage renal disease (ESRD) patients. Methods: This study included 80 non-diabetic ESRD patients [mean age, 52.8±13.7 years; dialysis duration, 67.1±52.0 months; hemodialysis (HD), 35 pts; peritoneal dialysis (PD), 45 pts] who survived for more than 3 months after the start of dialysis, and serum ADPN levels were measured at the beginning of the study. We conducted a longitudinal follow-up to evaluate the association of serum ADPN level with cardiovascular outcomes for 29.3±6.7 months. Results: ADPN was inversely correlated with fasting serum insulin (r=-0.309, p=0.006) and HOMA-IR (r=-0.321, p=0.004) in ESRD patients. In a multiple linear regression analysis adjusted for age, gender, waist to hip ratio (WHR), and HDL-cholesterol, HOMA-IR (β=-0.880, p=0.041) was an independent factor associated with serum ADPN level. Kaplan-Meier analysis revealed that patients with higher ADPN levels (≥15.8 μg/mL) had a significantly higher survival rate compared with lowers (<15.8 μg/mL) (p=0.032). Cox proportional hazard model adjusted for age, WHR, creatinine, CRP, and previous CVD history revealed that serum ADPN level (HR, 0.899; 95% CI, 0.818-0.987; p=0.026) was an independent determinant of cardiovascular outcomes. Conclusion: These findings suggest that lower ADPN levels independently predict cardiovascular events in non-diabetic ESRD patients.

자가 면역성 갑상선염 환자에서 발생한 쇼그렌 증후군과 원위 세뇨관 산증 1예

안혜림 ( Hye Rim An ),배성창 ( Sung Chang Bae ),이기병 ( Ki Byung Lee ),이용규 ( Yong Kyu Lee ),김좌경 ( Jwa Kyung Kim ),박형천 ( Hyeong Cheon Park ),하성규 ( Sung Kyu Ha ),이정은 ( Jung Eun Lee ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.1

A 52-year old woman, who had hypothyroidism associated with autoimmune thyroiditis for 5 years, was hospitalized for tingling sensation and muscle weakness of both lower extremities. Her initial laboratory findings showed severe hypokalemia, metabolic acidosis, and high titer of thyroid autoimmune antibodies. She was diagnosed of distal renal tubular acidosis by bicarbonate loading test (FEHCO3-<3.0%) and renal calcifications on pre-enhanced CT scan. Since she had other symptoms of xerostomia and xerophthalmia, primary Sjogren`s syndrome was diagnosed by Schirmer test, salivary scan, and serologic findings. She was treated with potassium citrate, potassium chloride, and hydroxychlorquine. Four months later, she has remained well with those treatments. There were only a few case reports about distal renal tubular acidosis associated with Sjogren`s syndrome and autoimmune thyroiditis. In Korea, there has not been any report of such cases. Therefore, we report a case of distal renal tubular acidosis and Sjogren`s syndrome in a patient with autoimmune thyroiditis.

Full-mouth rehabilitation by immediate implantation combined with orthognathic surgery: a clinical report

안혜림,허지예,김철훈,황희성,김복주,Ahn, Hye-Rim,Heo, Ji-Ye,Kim, Chul-Hoon,Hwang, Hee-Seong,Kim, Bok-Joo The Korean Academy of Prosthodonitics 2016 대한치과보철학회지 Vol.54 No.1

악교정 수술과 임플란트 보철을 통한 전악재건술의 임상적 치료는 보철과 의사에게 도전적인 과제이다. 본 증례는 골격적 부조화를 가진 다발성 우식증 환자의 진단과 치료에 있어서 치의학의 여러 분야의 협진을 보여주었다. 그 결과로 악교정 수술을 동반한 발치 후 즉시 임플란트 식립 및 조기 하중을 가하는 임플란트 보철물에 의한 전악 재건이 예견가능하고 효과적인 치료 방법이었기에 이를 보고하고자 한다. Clinical therapy that combines full-mouth rehabilitation with immediate implantation and orthognathic surgery poses a challenge to prosthodontists. This clinical report describes a multidisciplinary approach to the diagnosis and treatment of a patient presenting with skeletal discrepancy and rampant caries. The results thus achieved indicate that full-mouth rehabilitation by fixed immediate and early loading implantation accompanied by orthognathic surgery can be a predictable and effective treatment procedure.

초심상담자들의 자해 및 자살 위기 상담 수퍼비전 경험 분석 : 합의적 질적 연구법(CQR)을 중심으로

최혜림(Choi, Hye-Rim),최영숙(Choi, Yeong-Sook,안진아(Ahn, Jina) 한국교육치료학회 2024 교육치료연구 Vol.16 No.1

본 연구는 초심상담자들이 상담한 자해 및 자살 위기 상담사례 수퍼비전의 구체적인 경험을 추적하여, 위기 역량 강화를 위한 수퍼비전 구성요소를 탐구하고자 한다. 이를 위해, 위기 상담 수퍼비전을 받은 초심상담자 10명을 대상으로, 수퍼비전 사전 기대, 수퍼비전의 긍정적 성과, 수퍼비전의 아쉬운 점을 면담하고, 합의적 질적 연구 방법(CQR)으로 분석하였다. 연구 결과, 총 3개의 영역에서 20개의 범주가 도출되었다. 첫째, 수퍼비전 사전 기대 영역에서 참여자들은 위기 사례에 대한 명확하고 구체적인 상담 방안을 가장 기대하였으며, 본인의 위기 개입 적절성을 점검받길 원하였다. 둘째, 수퍼비전의 긍정적 성과로 위기 개입 어려움에 대한 지지와 상담자의 애씀에 대한 타당화, 위기 개입 관련 의학적 지식과 실무정보 제공, 위기 이면의 내담자 삶에 대한 이해 확장이 주로 도출되었다. 셋째, 수퍼비전의 아쉬운 점은 내담자의 특수성과 동떨어진 원론적인 제언과 지도받은 내용을 내담자에게 어떻게 적용할지 구체적인 방안이 부족했던 점이 주로 도출되었고, ‘못했거나 놓쳤다’는 평가적인 지적에 긴장감이 고조됨으로 분석되었다. 이상의 내용을 종합하여 초심상담자를 위한 위기 상담 수퍼비전이 갖추어야 할 요소들을 논의하였다. This study explores novice counselors’ experiences in receiving supervision for self-harm and suicide crisis counseling and identifies critical components of supervision to enhance crisis competency. Ten novice counselors who underwent crisis counseling supervision were interviewed about their expectations, positive outcomes, and disappointments. Using Consensual Qualitative Research(CQR), the study identified 20 categories across three areas. The counselors’ primary expectation was to receive a clear, specific crisis intervention plan and verify the appropriateness of their crisis response. Positive outcomes included support for crisis intervention challenges, validation of their efforts, medical/practical knowledge provision, and deeper client understanding. Disappointments centered on the lack of a concrete plan to apply supervision guidelines, which often did not align with clients’ unique needs and increased tension from assessment critiques. The findings inform the essential elements that crisis counseling guidance for novice practitioners should encompass.

자연동(自然銅)에 대(對)한 문헌적(文獻的) 고찰(考察)

설재욱,김세진,안혜림,정일문,신미숙,장하정,최진봉,Sul, Jae-Uk,Kim, Se-Jin,An, Hye-Rim,Chung, Il-Mun,Shin, Mi-Sook,Jang, Ha-Jeong,Choi, Jin-Bong 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.1

Objectives: The aim of this study is to find the therapeutic meaning of the Pyrite in herbal medication. Methods: About the origin, the component, the processing the drug, the properties and tastes of drugs, the meridian tropism, the effects, the treating disease, the contraindication and the method of administration. We have researched thirty three literatures to mention the pyrite in time sequence. Results: 1. The pyrite belongs to the metallic herbs and it consists of Iron sulfide, sometimes containing small amounts of cobalt, nickel. silver, and gold. 2. The processing the drug are the tempering, the annealing with vinegar. the refining drug with water or RADIX GLYCYRRHIZAE and et cetra, and accoring to these methods, the pyrite classified into three groups - the rough pyrite, the tempered pyrite, the annealed pyrite. 3. The properties and tastes of drugs is pungent and regular. If pyrite is well refine, it is nearly safe form the metallic virulence. the meridian tropism is mainly liver meridian. 4. From old times, pyrite has come into general use to treat the injury of muscles and tendons and bone facture because it is effective on dissipating blood stasis, alleviating pain and reunion of bone, muscles and ligament. 5. When the symptom is gone, a medicine to contain pyrite must be stoped taking. Because of pyrite's effect on regulateing Gi and promoting blood flow. Conclusions: This study showed that the pyrite is useful herb to treat the injury of muscles and tendons and bone facture.

소아비만의 효과적인 접근을 위한 문헌적 고찰 -1996~2007년 국외 논문을 중심으로

신미숙 ( Mi Sook Shin ),안혜림 ( Hye Rim Ahn ) 한방비만학회 2007 한방비만학회지 Vol.7 No.1

This study was designed to collect the latest papers and to find more effective approach for childhood obesity. Methods : We searched 107 papers in English from Pubmed(www.ncbi.nlm.nih.gov) and selected 52 in favor of our study. In addition to that, we searched 29 papers in Chinese from www.cnki.net. Results are as follows. Results and Conclusions : There are not completely new treatments for childhood obesity. Instead of that, many studies aimed for prevention through family education, nutrition education, and exercises education. Specially, because some diseases including hypertension, diabetes and heart disease are connected with obese children, medication can be prescribed optionally. In that case, their mental health must be laid emphasis. And in China, TCM(Traditional Chinese Medicine) is very common treatment for childhood obesity. Acupuncture, herb medication and manual therapy could be used usefully. It is suggested that above latest treatments can be combined with Korean traditional treatments method in treating obese children.

고령 혈액투석 환자에서 바이오임피던스법으로 측정한 체수분량 상태

이신아 ( Shin A Lee ),안혜림 ( Hye Rim An ),류정화 ( Jung Hwa Ryu ),유민아 ( Min A Yu ),류동열 ( Dong Ryeol Ryu ),김승정 ( Seung Jung Kim ),강덕희 ( Duk Hee Kang ),최규복 ( Kyu Bok Choi ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6

Purpose: This study was aimed to compare hydration status between young and elderly end-stage renal disease (ESRD) patients on hemodialysis (HD) and to analyze factors related to overhydration. Methods: We measured fluid status before a mid-week HD session in clinically stable 47 patients on maintenance HD using bioimpedance spectroscopy (BIS) device. In addition, weight and blood pressure (BP) were recorded during the treatment. Results: Participants were divided into young (<65 years, n=32) and elderly (65 years, n=15) patients.≥In elderly patients, pre-HD diastolic BP, intracellular water (ICW), and lean tissue index (LTI) were significantly lower and extracellular water (ECW)/total body water (TBW) was significantly higher than in young patients. However, there were no differences in pre-HD body mass index (BMI), ultrafiltration volume, pre-HD systolic BP, TBW, ECW, and fat tissue index between the two groups. ECW/TBW ratio and LTI were significantly correlated with age. In a multivariate regression analysis, age and pre-HD pulse pressure were significantly associated with ECW/TBW. Conclusion: Although BMI and TBW of elderly ESRD patients were similar to those of young patients, ICW and LTI were lower and ECW/TBW was higher in elderly patients than in young patients. Therefore, clinical manifestations related to overhydration may develop more frequently in elderly patients compared with young patients.

코로나19 팬데믹시대 노인건강유지를 위한 실내운동기구 디자인제안

곽봉철(Kwak Bong Cheol),안혜림(Ahn Hye Rim) 휴먼이미지디자인학회 2022 한국휴먼이미지디자인 Vol.4 No.1

코로나19시대의 고령자의 운동부족과 우울증세를 예방하고 활기차고 건강한 생활을 위한 기기를 제안한다. 특히 1인 가구의 고령자의 실태를 조사·분석하고 고령자들의 운동실태와 코로나의 영향으로 일어날 수 있는 건강상태를 조사하였다. 이를 위해 노인들의 운동 실태와 건강상의 문제점 등을 조사하였다. 조사와 분석들을 통하여 실내운동기기를 아이디어 제안을 하고 이에 맞는 샘플을 제안하는 것으로 하였다. 그 대상 제품은 DDR개념의 운동기구와 유니버설디자인의 원칙과 원리를 활용하여 디자인을 제안하였다. This study proposed exercise equipment for preventing the lack of exercise and depression of the elderly in the age of COVID-19 and leading a lively and healthy life. In particular, it investigated and analyzed the actual condition of the elderly in single-person households and surveyed the exercise condition of the elderly and their health status that might occur due to the influence of COVID-19. For this purpose, it investigated the exercise status and health problems of the elderly. It proposed the idea of indoor exercise equipment and the design suitable for it through research and analysis. It proposed the design of the target product by using the DDR-concept exercise equipment and the principles and principles of universal design.

보디빌더에서 발생한 횡문근융해증 1예

박형순 ( Hyung Soon Park ),장성일 ( Sung Il Jang ),이용규 ( Yong Kyu Lee ),안혜림 ( Hye Rim An ),박형천 ( Hyung Chon Park ),하성규 ( Sung Kyu Ha ),문성진 ( Sung Jin Moon ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4

Rhabdomyolysis is a serious and potentiallylethal disease that can develop from a variety of traumatic and nontraumatic conditions. In this report, the authors describe a case of rhabdomyolysis that occurredafter a body-building tournament. A 32-year-old body-builder was admitted due to quadriplegia and muscle pain. The patient had a serum potassium level of 1.8 mmol/L, creatinine phosphokinase level of 5,414 IU/L and urine myoglobin of 128.1 ng/ml. He had taken anabolic androgenic steroids for 6 months and overate himself with carbohydrate food after the tournament. Possible causes for the rhabdomyolysis were hypokalemia, exercise, and anabolic androgenic steroids, etc. His condition was fully recovered without complications after potassium replacement and general supportive care. Body-builders may be exposed to rhabdomyolysis risk factors such as diet control, weight reduction, and taking steroids. Therefore, special attention and education on rhabdomyolysis should be provided to body-builders.

소나무재선충 생물학적 방제를 위한 Bacillus licheniformis MH48의 선발 및 특성 규명

정민해 ( Min Hae Jeong ),양서영 ( Seo Young Yang ),이용성 ( Yong Sung Lee ),안영상 ( Young Sang Ahn ),박윤석 ( Yun Serk Park ),한혜림 ( Hye Rim Han ),김길용 ( Kil Yong Kim ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

Pine wilt disease (PWD) caused by pine wood nematode, Bursaphelenchus xylophilus, has become the most serious threat to pine trees in Korea. This study was subjected to investigate effective biological control agent against PWD. To select nematocidal bacteria against PWD, Bacillus licheniformis MH48 was selected among five bacteria due to its high nematocidal potential. B. licheniformis MH48 was tested for cell growth and protease activity to evaluate its nematicidal potential. In the B. licheniformis MH48, cell numbers were highest three days after incubation, while protease activity was highest after seven days. In the effect of different concentrations of B. licheniformis MH48 culture broth against B. xylophilus, 20% concentration of culture broth showed approximately 80% of pine wood nematode mortality compared to the control. Especially, pine wood nematode``s cuticle layers were degraded two days after treatment of B. licheniformis MH48 culture broth. The present study suggests that B. licheniformis MH48 can be one of the potential biocontrol candidates against pine wood nematode due to its ability to produce protease.