유용한 생체고분자 키틴

안창범,김세권,이응호 한국생명과학회 1993 생명과학회지 Vol.3 No.2

키틴은 N-아세틸-D-글루코사민 잔기가 다수 beta-(1, 4) 결합하고 있는 다당류이고, 그 탈아세틸화물을 키토산이라 한다. 키토산도 D-글루코사민의 beta-(1, 4) 중합체이지만 보통 약간의 아세틸기를 가지고 있는 것을 키토산이라 부르고 있다. 현재로는 제조 키틴의 대부분이 키토산으로 변환되어 응집제로서 폐수처리에 이용되고 있고, 기타 많은 용도가 개발되어 있지만 아직 연구단계에 있다. 따라서 키틴이나 키토산 분자의 잠재적 기능을 개발하여 인간생활에 유효하게 이용하도록 한다는 것은 폐기물 처리나 미이용 지원의 개발이라는 측면에서 볼 때 중요한 문제라고 볼 수 있다. 따라서 본고에서는 키틴의 생물계에서의 분포, 입체배좌, 제조법, 물성 및 기능성 그리고 그 용도에 대해 간추렸다.

Effect of Combined Traditional Acupuncture and Applied Kinesiology on Lumbar Diseases

안창범,Lee Sang-Ju,Park Yeo Bin,Park Yun Leong 대한침구의학회 2020 대한침구의학회지 Vol.37 No.2

Background: Several Korean medical doctors have been practicing applied kinesiology (AK), invented in 1964 by Dr. George J Goodheart, USA. Although the efficacy of traditional acupuncture (TA) and pharmacopucture treatment for lumbar conditions/diseases has been examined, the possible benefits of combining TA and AK have not been reported. Therefore, the aim of this study was to report the effects of combining TA and AK treatment for lumbar disorders using the Japanese Orthopedic Association lumbar score (JOALS) assessment.Methods: There were 21 outpatients treated at Samse Korean Traditional Hospital between March 2018 and September 2018, who presented with L4/L5 or L5/S1 root radiculopathy associated with lumbar spinal stenosis (LSS) and lumbar herniation of intervertebral disk (LHID). They were treated 10×(2 sessions per week, for 5 weeks) with TA and AK approaches that included a category block, manipulation or strain/counterstrain treatments. The primary outcome was mainly assessed using the JOALS score which was used before (0 ×), during (5 ×), and after treatment (10 ×).Results: There were 19 patients diagnosed with LSS and 2 were diagnosed with LHID. Using the JOALS assessment, TA and AK combined approaches improved the lumbar conditions of all 21 patients after 5 × treatmentsand continued to improve after 10 × treatments (<i>p</i> < 0.001).<br>Conclusion: Combined TA and AK treatment was effective in treating spinal conditions/diseases. Prospective, relevant, well-controlled protocols for TA and AK therapies for various conditions are needed.

초고속 자기 공명 영상 기법 - Echo Planar 영상 및 Spiral Scan 영상

안창범 대한자기공명의과학회 1999 Investigative Magnetic Resonance Imaging Vol.3 No.1

Echo Planar Imaging (EPI) Spiral Scan 영상을 초고속 자기공명영상 기법으로서 전체 k-space의 데이터를 한번 scan에 다 받을 수 있기 때문에 데이터 측정시간을 100ms 이내로 단축시킬 수 있다. 이러한 초고속 영상 기법은 최근 활발히 연구되고 있는 뇌기능 영상과 관련하여 중요도가 더욱 커지고 있다. EPI는 직각좌표계에서 데이터를 받기 때문에 재구성은 비교적 쉬우나 eddy current를 많이 야기시키는 단점을 가지고 있다. 반면에 Spiral Scan 영상은 먼저 데이터를 원 또는 직각좌표계로 interpolation을 한 후 재구성하여야 하는 단점이 있으나, 상대적으로 eddy current가 작고, 방향과 무관하게 균일한 point spread function을 가지며, 혈류와 관련한 위상이 스스로 rephasing 되어 심장 영상 등에 유리한 장점이 있다.

『 동경대전 』 의 역사적 연구

안창범 동학학회 2001 동학학보 Vol.2 No.-

용성산인(龍城山人) 이창원(李昌遠)의 사상학설(四象學說)과 체질침(體質鍼)에 대한 고찰(考察)

안창범,윤현민,허재영,권혜연,Ahn, Chang-beohm,Youn, Byuon-Min,Hea, Jae-young,Kwon, Hae-Yon 대한침구의학회 2002 대한침구의학회지 Vol.19 No.1

Objective : This study was carried out to review Chang-Won Lee's theory of Sasangand acupuncture of constitution. Methods : We have investigated Chang-Won Lee's unknown literature "Medicine of sassang "(四象醫學). Results : Constitutional acupuncture is based on the diversity of human being and medically developed the response variation to disease and acupuncture. The diversity is due to the Organ's Congenital Formation Variation based on human nature and it is categorized as four from physiology, pathology, symptoms, to therapy. Chang-Won Lee's constitutional acupuncture discriminated constitution of comparison palpations of right and left both sides. He insisted that constitution only four type(Sasang), not exist man of To-Hyoung (土形人) in "young -chu"(靈樞) and his constitutional acupuncture all used Jung-kyuck (reinforcement acupuncture method) and Seong-kyuck(reducing acupuncture method) of Sa-am(舍岩)

『(환단고기)桓檀古記』 위서론(僞書論) 비판

안창범 전국한자교육추진총연합회 2006 한글한자문화 Vol.80 No.-

수산식품의 단백질분해효소

안창범 전남대학교 수산과학연구소 2003 수산과학연구소논문집 Vol.12 No.-

Proteases contained in seafood are important because they make a positive contribution to fermentations and other industrial processes and, on the other hand, can also be detrimental to the quality of raw and cooked fish and shellfish during chill storage or heat processing. Important groups of endogenous fish proteases inc1ude those ori밍nating from diges삼ve organs, those present within the musc1e cell, and enzymes synthesized and secreted in the extracellular matrix. Research has been undertaken to identify specific proteinases that cause problems like gapin용 meat softening, and meat-gel softening in seafood. However, our current knowledge of proteinases and the specific way they contribute to quality loss in seafood is fragmented and incomplete. In recent years several new groups of proteinases have been identified in seafood tissues and long held concepts and mechanisms are being questioned. Examples of recently identified groups of proteinases inc1ude multicatalytic enzymes, neutral-heat activated proteinases, matrix metalloproteinases and ATP-dependent proteinases in fish muscle tissue. Other recent findings are that specific cathepsins can hydr이yse certain myofibril proteins at the natural pH of fish meat, that modori in cooked fish gels may not be caused by heat stable alkaline proteinases, and that despite the low content of connective tissue in aquatic organisms, degradation of collagen and other extracellular matrix components by endogenous proteinases may be detrimental to texture and appearance of seafood.

수산 부산물의 유효이용

안창범 전남대학교 수산과학연구소 2003 수산과학연구소논문집 Vol.12 No.-

The major components of processing discards of seafoods incIude edible portions such as tongue, cheeks, stomach and liver from fish, proteins from residual flesh, fish skin, chitinous materials, carotenoid pigments, flavorants, gut enzymes, and anti-freeze proteins from blood of cold-temperature fish. The potential utilization of each of these ingredients in a variety of applications has been the focus of attention in recent years. Preparation of protein concentrates and hydrolysates as well as surimi from residual flesh remaining on fish frames after filleting has received increasing attention in recent years. MeanwhiIe, isolation of anti-freeze proteins from blood plasma of fish in cold waters has been important both for production of transgenic fish and for extending the shelf-life of human organs intended for transplant purposes. Cold-temperature 얹zymes from gastrointestinal tracts of fish may serve as processing aids in the food industry. In addition, chitosan derivatives have been used for a v값iety of applications. There are over 200 current and potential applications of chitinous materials in biotechnology, food processing, agriculture, pharmacy, medicine and natural environment preseπation. Furthermore, utilization of carotenoid and carotenoprotein extracts, prepared from shellfish processing discards, in aquaculture feed formulations intended for pigmentation of salmonids has been reported. Possible recoveη of flavorants from shellfish processing discards or from cook water has been a야empted. In addition, marine lipids, prepared from fish liver or as a by-product in fish meal production, have been used as a source of omega-3 fatty acids for pharmaceutical and food applications.

갑각류부산물을 이용한 키틴의 제조 및 이용에 관한 연구 2. 키토산필름포장이 반염건(半鹽乾) 전갱이의 가공 및 저장 중 품질에 미치는 효과

안창범,이응호,AHN Chang-Bum,LEE Eung-Ho 한국수산과학회 1992 한국수산과학회지 Vol.25 No.1

폐기되고 있는 꽂게껍질로 만든 키토산필름의 포장에 의한 반염건전갱이제품의 제조 및 저장중품질유지에 미치는 영향에 대해 실험하였다. 대조제품과 키토산필름포장제품의 수분함량은 각각 $60.6\%,\;65.0\%$로서 키토산필름포장제품의 수분함량이 $4.4\%$ 높았다. 저장중 pH, 휘발성염기질소 및 아미노질소의 증가폭은 키토산필름포장제품이 적었다. 생균수는 저장초기에 약간 감소하다가 그 이후로 계속 증가하여 대조제품은 14일째에 $8.0\times10^5/g$이었으나 키토산필름포장제품은 저장 20일째에도 $7.0\times10^5/g$이었다. TMAO는 저장중 감소하고 TMA는 증가하는 경향이었고 그 증감의 폭은 키토산필름포장제품이 적었다. TBA값과 과산화물값은 저장중 증가하다가 저장 14일 이후로 감소하였고 증가폭은 키토산필름포장제품이 적었다. 관능검사결과 저장 14일째에 대조제품은 키토산필름포장제품에 비해 현저히 품질이 떨어졌고 키토산필름포장제품은 저장 14일째에도 식용가능하였다. 이화학적 및 관능적평가로 미루어 보아 키토산필름포장 제품은 대조제품에 비해 품질유지면에서 우수하다는 결론을 얻었다. The preservative effect of chitosan film packing on quality of lightly-salted and dried horse mackerel was studied. In preparation of chitosan film, blue crab shell chitosan was dissolved in dilute acetic acid$(1.0\%,\;v/v)$, filtered, and spreaded on plastic plate and dried at $50\pm2^{\circ}C$. The chitosan film thus obtained was neutralized with 1.0N NaOH for 2 hrs and dried at room temperature after washing several times with distilled water. The lightly-salted and dried horse mackerel product was prepared by drying for 4 hrs at $40\pm2^{\circ}C$ in hot air dryer after packing with the chitosan film. During storage at $5.0\pm0.5^{\circ}C$, moisture content of the product was higher than that of the reference, but contents of VBN(volatile basic nitrogen) , amino nitrogen, and TMA of the product on dry basis were lower than those of the reference. Viable cell count, TBA value, and peroxide value of the product were also lower than those of the reference. Judging from the result of sensory evaluation, the chitosan film packing in the storage of lightly-salted and dried horse mackerel was remarkably elongated shelf-life of the product. From the results of chemical and sensory evaluation, it was concluded that chitosan film packing was an effective method for retaining the quality of lightly-salted and dried horse mackerel.

객체지향과 멀티미디어 기술을 이용한 전산화 신경 심리 검사 시스템

안창범,김휴정,신진교,박준모,이성훈 대한의용생체공학회 1999 의공학회지 Vol.20 No.5

임상적인 응용을 목적으로 하는 전산화 신경 심리 검사 시스템을 개발하였다. 개발된 시스템은 국소적 뇌기능 장애 진단에 뛰어난 14개의 검사록 구성되어 있으며 집중력·언어능력, 공간 및 도형 인지 능력, 기억력, 운동 집중 능력 등을 진단하게 된다. 개발된 시스템은 멀티미디어 객체지향개념에 의거하여 설계 구현되었고, 마이크로소프트 Windows 에 기반을 둔 그래픽 인터페이스를 채용하여 운용이 용이하도록 하였다. 또한 마우스와 터치스크린을 이용하여 피검사자로부터 입력을 손쉽게 받아들 일수 있도록 하였으며, 색체 단어검사, 범주화검사, 언어기억검사들을 한글화하여 검사의 효용성을 향상시켰다. 개발된 시스템을 정상인 그룹과 환자에 적용한 결과 뇌기능 장애 진단에 유용하게 사용될 수 있음을 확인할수 있었다.