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      • KCI등재후보

        신이식후 발생하는 감염에 대한 고찰

        김재필(Jae Phil Kim),조대옥(Dae Ok Cho),고경식(Kyung Sik Ko),안재형(Jai Hyung Ahn),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.1

        N/A Objectives: Renal transplantation is a major therapeutic advance for patients with chronic renal failure. But recipients of renal transplantation are prone to infection with both common and unusual organisms. And infectious diseases remain a major cause of morbidity and mortality in renal transplant recipients. This study was to analyze the infections in renal transplant recipients; its occurrence according to sites and organisms; comparison among immunosuppressive agents; prognostic differences of urinary tract infections(UTI) between those developed during 1 month after transplantation and those not developed; graft outcome; and patients mortality. Mothods: 181 renal transplant recipients were examined. They received renal transplantion between january 1979 and December 1992 at the Kyung-Hee University Hospital. 158 of them received transplantation from living-related donors, 22 from living-unrelated donors, and 1 from cadaver donor. Their age at the time of transplantation ranged from 14 to 66 years(mean 35.6 years), and the male to female ratio was 2.3: 1. The observation period ranged from 1 to 144 months(41.26±31.71, mean±S. D.). Results: 1) 110 recipients(60.7% of total) had 232 episodes of infectious complications whereas 71(39.3% of total) had no infectious episodes. About half of infectious episodes(128 episodes, 55.2% ) occurred during 1 month after transplantation. 2) The most common site of infection was urinary tract(138 episodes, 59.2%) whth the next sites coming in this order, bacteremia(32 episodes, 13.8%), pulmonary(21 episodes, 9.1%), and skin(21 episodes, 9.1%). 3) The causative organisms of UTI ranked in this order E. coli 21.7%, staphylococcus spp 14.5%, and pseudomonas spp 13.0%. 4) The causative organisms of bacteremia ranked in this order E. coli 34.4% salmonella spp 18.8%, pseudomonas spp 12.5 %, and staphylococcus spp 12.5%. 5) There was no significant differences of infectious episodes among immunosuppressive regimens. 6) Early UTI group(UTI occurred during 1 month after transplantation) recorded significantly higher incidence of urinary tract infections after 1 month that followed than non-UTI group. But there was no differences between two groups on graft and patients outcome. 7) The major cause of death was life-threatening infections(63.2 %). Conclusion: Most infections due to various organisms may occur during 1 month after transplantation. And still they constitute a major cause of death in renal transplant recipients.

      • 소음순에 발생한 Bowen씨 병 1예

        안성호,안재형,황영수,고승희,고재환,김용봉,이혜경 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2

        Bowen's disease is developed on skin or mucosal area. It is precancerous lesion and rarely progresses to invasive cancer. This disease can be developed in whole body, but rare in perineal and vulvar area. The authors experienced a case of Bowen's disease on labium minor and present it with brief review of the literature.

      • KCI등재후보

        Anti-Neutrophilic Cytoplasmic Autoantibody(ANCA) 연관성 급속 진행성 사구체 신염에 관한 임상경험 2 예

        김명재,양문호,박원도,이태원,임천규,조대옥,안재형,김신규 대한내과학회 1992 대한내과학회지 Vol.43 No.4

        Antineutrophilic cytoplasmic autoantibodies (ANCA) are specific for constituents of neutrophilic granules and monocyte lysosomes, and two types, C-ANCA and P-ANCA was recognized by indirect immunofluorescence microscopy. ANCA are found in patients with necrotizing systemic vasculitis, such as Wegener`s granulomatosis and polyarteritis nodosa and patients with idiopathic crescentic glomerulonephritis. ANCA-associated glomerulonephritis are characterized by necrosis, crescent formation and a paucity of demonstrable immune deposits in renal biopsy. We report two cases of rapidly progressive glomerulonephritis, who had pauci or no immune deposits in renal biopsy and positive C-ANCA in indirect immunofluorescence microscopy.

      • KCI등재후보

        Cyclosporine 을 사용하는 신이식 환자에서의 정상만삭분만 2 예

        김명재,김배영,이태원,오보훈,임천규,안재형 대한내과학회 1992 대한내과학회지 Vol.43 No.4

        Background: A successful pregnancy and delivery in renal-transplanted patients has been increased with the high graft survival rate by the development of the immunosuppressive agents using following renal transplantation. And so attentions have been focused on the effects of immunosuppressive agents on the graft kidney and fetus during pregnancy after renal transplantation. Results: We presented successful pregnancies and fullterm deliveries with cesarean section in two recipients with regimens of cyclosporine, azathioprine and prednisolone after renal transplantation. Conclusion: Cyclosporine, azathioprine and prednisolone have on deliterious effect to the mother and fetus in our two cases but, more study is needed to identify the effects of immunosuppressive agents on the graft kidney and fetus during pregnancy after transplantation.

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