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Helicobacter pylori vacA 대립유전자의 Mosaicism과 Signal Sequence의 한국고유 시발체
안연화,김흥렬,이지은,황태숙,최연호,Ahn, Yeon-Hwa,Kim, Heung-Ryel,Lee, Ji-Eun,Hwang, Tae-Sook,Choe, Yon-Ho 대한소아소화기영양학회 2001 Pediatric gastroenterology, hepatology & nutrition Vol.4 No.2
목적: H. pylori의 vacA 대립유전자는 종족과 지역에 따라 다양하게 나타나고 있다. 저자들은 H. pylori에 감염된 소아의 위생검조직에서 vacA 대립 유전자에 대한 중합효소연쇄반응과 유전자염기분석을 실시하여 한국의 signal sequence와 mid-region의 다형성 및 고유의 시발체를 연구하고자 하였다. 방법: 상부 위내시경을 시행한 후 H. pylori 감염으로 진단된 10~18세 50명의 환아를 대상으로 위생검조직을 이용하여 vacA 대립유전자에 대한 PCR과 DNA 분석을 실시하였다. 이들 결과와 다른 나라의 vacA 대립유전자를 비교분석하였고 우리나라의 고유한 염기배열을 갖는 시발체를 제작하였다. 결과: 1) 서구의 시발체를 사용한 50명 중 30명(60%)에서 모두 s1이 검출되었고 이중 s1a가 14명, s1c 15명, s1a/s1c hybrid가 한 명이었으며 s1b는 발견되지 않았다. s1c/m1이 가장 많은 형이었다. 2) 우리 나라에 공통으로 발견되는 염기변이가 s1a에서는 GGGAGCGTTR, s1c는 GGGGYTATTG 이었으며 이들을 이용하여 새로운 시발체를 고안하였다(VASK-F, VASK-R, S1AK-F, S1CK-F). 새로이 제작된 시발체로 처음의 50개 조직을 재검한 결과 50개 모두에서 s region이 양성이었다. 결론: 우리 나라의 주된 vacA 대립유전자형조합은 s1c/m1이었고, vacA signal sequence의 한국 고유의 시발체를 만들었음을 보고하는 바이다. Purpose: Helicobacter pylori has been known to have diverse vacA allelic types. The purpose of the study was to identify vacA diversity in Korea and design new primers for signal sequence alleles indigenous to Korea. Methods: Fifty antral biopsy specimens, which had been proven to be H. pylori-positive, were examined for vacA status; signal sequence and mid-region. After PCR amplification and DNA sequencing, vacA alleles of Korean H. pylori strains were compared with those from other countries. Results: Among Korean H. pylori strains vacA alleles with all combinations of signal sequence and mid-region were found, with the exception of s1b or s2. vacA genotype s1c/m1 was predominant in Korea. We found that GGGAGCGTTR in s1a and GGGGYTATTG in s1c were the indigenous sequences to Korea and constructed the new Korean specific primers for the vacA signal sequence; VASK-F, VASK-R, S1AK-F, and S1CK-F. Conclusion: This study showed that s1c/m1 is the predominant type of vacA allele in Korea. We designed new primers for the vacA signal sequence.
안연화 ( Yeon Hwa Ahn ),여중석 ( Joong Suk Yeo ),이진영 ( Jin Young Lee ),한영신 ( Young Sin Han ),안강모 ( Kang Mo Ahn ),이상일 ( Sang Il Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.3
목적: 땅콩 알레르기는 치명적인 아나필락시스를 일으킬 수 있는 식품 알레르기로, 조리법에 따라서 땅콩단백의 알레르기 항원성이 달라질 수 있다. 본 연구는 다양한 조리법에 따른 땅콩의 구성단백의 변화를 분석해 보고자 하였다. 방법: 생땅콩과 가공처리한 7가지 종류(삶은 땅콩, 10분, 20분, 30분 구운 땅콩, 튀긴 땅콩, 식초에 절인 땅콩, 땅콩버터)의 땅콩을 분쇄한 후, PBS 처리하여 단백을 추출하였고, SDS-PAGE를 시행하여 단백분획을 확인하였다. 그리고, 아토피피부염 환아 중 혈청내 땅콩에 대한 특이 IgE가 15 kU/L이상을 보인 환아 8명의 pooled serum으로 8종류의 땅콩 단백과 IgE immunoblot을 시행하였다. 결과: SDS-PAGE상 구운 땅콩에서는 열처리 시간에 관계없이 Ara h 2에 해당하는 진한 단백띠를 보였고, 튀긴 땅콩과 식초절임에서는 Ara h 1에 해당하는 단백띠가 사라졌다. 조리법에 관계없이 Ara h 3에 해당하는 단백띠가 일정함을 보였으며, 특히 식초절임의 37-40 kDa에서 강한 단백띠를 보였다. IgE immunoblot상 10분 구운 땅콩에서는 Ara h 2 해당 단백띠와 IgE 반응성을 보였고, 튀긴 땅콩과 식초절임에서 Ara h 1 해당 단백띠와의 반응성은 보이지 않았다. 식초절임에서는 전반적인 IgE 반응성은 보이지 않았다. 결론: 저자들은 구운 땅콩에서는 Ara h 1보다는 Ara h 2에 해당하는 단백띠의 항원성이 증가하였고, 튀긴 땅콩과 식초절임에서는 땅콩단백의 항원성이 감소함을 확인할 수 있었다. Purpose: Peanut allergy is a major cause of fatal food-induced anaphylaxis. Cooking methods can affect the allergic properties of peanut proteins. The aim of this study was to determine the allergenicity of peanut according to cooking methods. Methods: Eight kinds of peanut were included in the study: raw peanut, boiled peanut, roasted peanut (10 min, 20 min and 30 min), peanut butter, fried peanut and vinegarish peanut. The proteins were extracted with PBS and analyzed using the SDS-PAGE IgE immunoblot assay with pooled sera from 8 patients with atopic dermatitis. These patients had peanut-specific IgE levels greater than 15 kU/L, which were measured by the CAP-FEIA. Results: The SDS-PAGE IgE immunoblot assay revealed more intense protein bands of Ara h 2 in roasted peanut and peanut butter than in raw, boiled, fried and vinegarish peanut. The protein band of Ara h 1 was not undetected in fried and vinegarish peanut. Ara h 3 had a stable band pattern in all samples, but there was the most prominent band at 37-40 kDa in vinegarish peanut. The IgE immunoblot assay revealed that 10 min roasted peanut had more IgE binding to Ara h 2, and there was no IgE binding to Ara h 1 in fried and vinegarish peanut. In vinegarish peanut, there was almost no IgE binding to it. Conclusion: The results of this study suggest that the roasted peanut may increase the allergenicity of Ara h 2 as compared to Ara h 1. Fried and vinegarish peanut may reduce the allergenicity of peanut. [Pediatr Allergy Respir Dis(Korea) 2009;19:233-240]
연구논문 : 단호박 첨가수준을 달리한 식혜의 저장 중 품질특성
안연화 ( Yeon Hwa An ),이인선 ( In Seon Lee ),김향숙 ( Hyang Sook Kim ) 한국식품조리과학회(구 한국조리과학회) 2011 한국식품조리과학회지 Vol.27 No.6
The new version of sikhye(sweet rice drink) was prepared by adding sweet pumpkin (SP) in order to improve customers` preferences for sikhye by modifying the color, and flavor, as well as health functionality. The independent variables were sweet pumpkin amount(0, 2, 4, 6, and 8% malt powder extract) and storage periods(0, 3, 6, 9, and 12 days). Each sample was measured by using physicochemical and sensory evaluations, and results were statistically tested to examine significant differences among samples. pH increased with higher amounts of added pumpkin. As additional levels of sweet pumpkin increased, the Hunter`s L value decreased, whereas the b value increased. In a consumer acceptance test, all characteristics except for sweetness were significantly different at p<0.05. The overall acceptability, including yellowness, malt aroma, and sweetness in the pumpkin added sample was estimated to be better than the comparative sample was. There was no significant difference between SP4, SP6, and SP8, but SP2 showed a lower preference than other samples.
한국의 청소년 운동선수들에서 Helicobacter pylori IgG의 높은 혈청 양성률
김흥열,안연화,최연호,이지은,홍윤철,Kim, Heung-Ryel,Ahn, Yeon-Hwa,Choe, Yon-Ho,Lee, Ji-Eun,Hong, Yun-Chul 대한소아소화기영양학회 2001 Pediatric gastroenterology, hepatology & nutrition Vol.4 No.2
Purpose: Poor living conditions such as overcrowding and sharing a bed are reported to be significant risk factors for H. pylori infection throughout childhood. We investigated the prevalence of Helicobacter pylori infection in Korean athletes who are obliged to live together in training camps over six months a year. Methods: Blood sampling and surveying through questionnaire were performed on 440 regular high school students (228 boys and 212 girls) and 220 athletes (148 boys and 72 girls) of a physical education high school. We measured serum IgG Ab to H. pylori in order to compare the prevalence of H. pylori infection between normal adolescents and athletes. In addition, we conducted a nutritional analysis and questionnaire survey for socioeconomic status in order to compare other risk factors that might influence H. pylori infection between groups. Results: The prevalence (43.2%) of H. pylori infection in athletes was higher than that (22.7%) in the controls. No significant differences in the nutritional factors or socioeconomic status, such as Hollingshead index, type of house, and crowding index, were found between the groups. Multivariate analysis showed that crowding and the difference in school type were the significant predictors of H. pylori seropositivity after controlling for dietary and socioeconomic factors. Conclusion: Living together in training camps might be a significant risk factor for H. pylori infection in athletes. 목적: 침대를 함께 사용하고 밀집된 공간에서 생활하는 것이 H. pylori 감염을 일으키는 의미 있는 위험 인자로 알려져 있다. 저자들은 훈련을 위해 합숙해야 하는 청소년 운동선수들에서 H. pylori 감염의 유병률을 조사하고 이를 일반 학생들과 비교해 보고자 하였다. 방법: 일반 고등학교 440명(남학생 228명과 여학생 212명)과 체육 고등학교의 운동 선수 220명(남학생 148명과 여학생 72명)을 대상으로 정맥 채혈과 설문지를 통한 조사가 이루어졌다. 첫째, 일반 학생과 운동 선수들의 H. pylori 감염의 유병률을 비교하기 위해 H. pylor에 대한 혈청 IgG 항체를 검사하였다. 둘째, H. pylori 감염에 영향을 미칠수 있는 위험 인자를 비교하기 위해 두 군간의 섭취하는 음식에 대한 영양 분석과 사회 경제적인 상태에 대한 설문지 조사가 시행되었다. 결과: 1) 육상 선수들의 H. pylori 감염의 유병률(43.2%)이 대조군(22.7%)에 비해 의미있게 높았다. 2) 두 군간에 영양섭취 및 Hollingshead 지표, 주택소유 여부, 혼잡지표 등의 사회경제적인 상태의 의미있는 차이는 없었다. 3) 다변량 회귀분석상 학교의 차이와 혼잡지표가 H. pylori 감염에 영향을 주는 유의한 인자였다. 결론: 훈련 캠프의 합숙생활이 청소년 운동 선수들에서 H. pylori 감염을 일으키는 의미있는 위험 인자가 될 수 있다.
건강한 4개월 영아에서 기흉으로 발현된 거대세포바이러스 폐렴 1예
강동희 ( Dong Hee Kang ),김수연 ( Su Yeon Kim ),김영은 ( Young Eun Kim ),고효정 ( Hyo Jung Koh ),안연화 ( Yeon Hwa Ahn ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.2
Cytomegalovirus (CMV) is the most common agent of congenital infections and opportunistic infections in an immunocompromised host. CMV in an immunocompetent host has inapparent infections, which are usually asymptomatic or cause mild mononucleosis-like symptoms. However, severe CMV diseases, such as pneumonia, hepatitis, gastrointestinal disease, often occur in a healthy infant. The association of CMV pneumonia with the development of pneumothorax has rarely been reported. We experienced a case of CMV pneumonia presenting as pneumothorax in a 4-month-old healthy infant, who was successfully treated with supportive care. CMV was confirmed by using CMV polymerase chain reaction of tracheal aspirates. This case suggested that CMV should be considered as a cause of viral pneumonia during the infant period. (Allergy Asthma Respir Dis 2021;9:104-108)
청소년 원발성 자연 기흉의 임상적 특징: 재발 관련 인자에 관한 연구
이승준 ( Seung Joon Lee ),차민아 ( Min A Cha ),우열륜 ( Yeol Ryoon Woo ),권은별 ( Eun Byul Kwon ),안연화 ( Yeon Hwa Ahn ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4
Purpose: The aim of this study was to investigate the clinical characteristics of primary spontaneous pneumothorax (PSP) in adolescents and identify risk factors for the recurrence of PSP. Methods: A total of 292 patients diagnosed with PSP from January 1998 to December 2011 were retrospectively studied. Clinical data on demographics, diagnostic imaging, therapies, and risk factors of recurrence were collected and analyzed. Results: The sex ratio of 292 patients was 19.8:1 (male:female), and the average age of the patients was 17.0 years. The average body mass index of the patients was 18.8 kg/m2. The most common presenting symptom was chest pain. There was no seasonal variation in the incidence of PSP. Thirty patients (10.2%) had a history of smoking. The most common location of PSP was the left side. Out of 249 patients, 169 (67.9%) had cysts (blebs/bullae). Fifty-four patients (18.5%) received oxygen therapy, 3 patients (1%) needle aspiration, 119 patients (40.8%) closed tube drainage, and 116 patients (39.7%) surgery. The recurrence rate was 38.6%. Smoking was associated with the size of pneumothorax (P=0.002). Also, the size of pneumothorax and surgery was associated with recurrence (P=0.040 and P=0.004). However, previously reported risk factors for recurrence were not identified in our patients. Conclusion: Pediatric PSP occurred mainly in males in late adolescence with normal body mass index. No significant risk factors were related to recurrence of PSP in our study.