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P-470 : Drug Delivery Application of L3 Phases Silicates -HAp composite
심창한,장정호,김경자 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.2
L3 phase hybrid gel based on interpenertrating network of thermosensitive poly(Nisoproptlacrylamide) gels shows highly controlled drug release pattern between roomtemperature and body-temperature. To elevate the biocompatibility of the hybrid gel, hydroxyapatite which is known the chemical and crystallography properties closely resemble hard tissue such as bone and tooth materials was blended . A sustainable positive thermo-responsive drug release profile is obtained. When the temperature rises, the polymer gel shrinks, squeezing the drug into the porous channels, and at the same time, opening the pore to the outside media. The drug slowly diffuses out of the porous channels. The overall release rate can be adjusted by changing the composition of the composite.
교액성 선천성 내부 탈장에 의해 발생한 단장 증후군 1례
심창은,문진수,김기홍,김한성,Sim, Chang Eun,Moon, Jin Soo,Kim, Ki Hong,Kim, Han-Seong 대한소아소화기영양학회 2004 Pediatric gastroenterology, hepatology & nutrition Vol.7 No.2
단장 증후군은 선천적 원인 혹은 후천적으로 장 절제술 이후 발생하여 흡수 장애 및 영양실조를 보인다. 최근에는 정맥영양, 식이요법, 호르몬 치료 및 수술적 치료로 대부분의 경우에는 정상적인 성장과 생활을 영위하게 되었다. 저자들은 내부 탈장으로 외과적 절제술 후 단장 증후군의 임상증상과 검사 소견을 보인 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Short bowel syndrome in children, most commonly results after extensive bowel resection for necrosis of the bowel. It may be caused by several intestinal catastrophes such as volvulus, hernia and necrotizing enterocolitis. The risk factors on short bowel syndrome are the remaining length of the bowel, the age of onset, the absence of the ileo-cecal valve and the time after resection. Macro and micronutritional deficiencies are the most significant complications of short bowel syndrome. We report a 5 year-old girl, who had a strangulated congenital transmesenteric hernia leading to short bowel syndrome accompanied by iron deficiency anemia.