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심재갑,심재홍 대한신경외과학회 1979 Journal of Korean neurosurgical society Vol.8 No.1
Arteriovenous malformation of the brain is a congenital abnormal communication between arterial and venous channels without the interposition of the capillary system and it not infrequently cause severe intracranial hemorrhage and neurological deficits. The authors are reporting three cases of cerebral arteriovenous malformations which underwent surgical treatment using the operating microscope under mannitolization without hypotensive anesthesia.
뇌의 신경교종과 수막종에서 성장촉진 인자와 증식세포핵항원(PCNA)에 관한 연구
심재갑,김인선,구병삼 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1
A recent revolutionary study in molecular biology leads to understand that growth factors are necessary for normal development and the function of the cells. It has also found that many of the growth factors or their respective receptors are related to products of transforming viral genes and normal cellular counterparts called proto-oncogenes. The activation of proto-oncogenes results in growth factor secretion or growth factor receptor expression. The concommitant expression of growth factors and of their receptors results in autocrine growth stimulation, related to the development of human cancers. In this study, the presence of estrogen receptor (ER-D_(5)) and epidermal growth factor receptor(EGFR). expression of c-myc protein. and the positivity of proliferating cell nuclear antigen (PCNA) were evaluated in 26 cases of low grade (13) and high grade (7) astrocytomas and glioblastoma multiforme (6), and 22 cases of meningiomas, by immunohistochemical staining on paraffin sections. The results are summerized as follows : 1. ER-D_(5) was positive in 9 among 22 cases of meningioma (40.9%), and in 4 among 26 cases of astrocytoma and glioblastoma multiforme (19.2%). 2. EGFR was positive in 20 of 22 meningiomas (90.9%), and 20 of 26 astrocytomas and glioblastoma multiforme than in low grade tumors. 3. C-myc protein was positive in all, except one, meningiomas and all malignant astrocytomas and glioblastoma multiforme. However, it was only positive in 8 among 13 cases of low grade astrocytoma (61.5%). The positivity was higher in the meningotheliomatous type of meningiomas than in other histologic types, and also higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 4. The PCNA-positive cells were absent or rarely seen in one case of meningiomas and 8 of 13 cases of low grade astrocytomas. The proportion of positive cells was higher in the meningotheliomatous type of meningiomas than in others, and higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 5. There was a positive correlation between the expressibility of EGFR, c-myc protein, and PCNA. The degree of positivity was higher in malignant forms of glial tumors.