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Representative NADPH oxidase inhibitors: Mechanism, Potency, and the Usage for various diseases
심승환(Seunghwan Shim),최용석(Yongseok Choi) 고려대학교 생명자원연구소 2022 생명자원연구 Vol.30 No.-
NADPH Oxidase(NOX)는 백혈구, 동맥벽, 뇌를 포함한 여러 종류의 세포에서 발견되며 활성산소(ROS) 생성을 유도한다. 사람은 NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1 및 DUOX2의 NOX isoform이 발현된다. 각 NOX isoform은 막 관련 효소와 세포질소단위체를 포함하는 다중 소단위체 복합체로 구성된다. NOX 활성화는 단계적으로 세포질 소단위체가 조립되어 막으로 이동하여 전자를 산소로 운반하고 최종적으로 초과산화물을 생성하는 과정이다. NOX를 통한 과산화물의 비정상적인 생성은 세포의 염증, 세포 성장, 진행형 퇴행성 등과 관련된 다양한 질병에서 중요한 역할을 하는 것으로 나타났다. 따라서 그동안 NOX 억제제를 개발하는 것은 유망한 치료법이라고 여겨져 왔고 많은 화합물 억제제들이 발표되었다. 본 논문에서는 대표적인 NOX 화합물 억제제, 화합물들의 화학적 특성, NOX에 대한 억제 효능, 억제 매커니즘 및 약물로서의 사용 제한에 초점을 맞출 것이다. NADPH Oxidase(NOX) induced reactive oxygen species(ROS) generation found on several types of cells including in leukocytes, artery wall, and brain. The human isoform complex comprises NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1 and DUOX2. Each NOX isoforms consists of multi-subunit complex including membrane-associated enzymes and cytosolic subunits. NOX activation is step-by-step process where cytosolic subunits are assembled and translocated to the membrane, leading to transport electrons to oxygen, and finally to produce superoxide. Abnormal production of superoxide via NOX has been shown to play an important role in various diseases related to inflammation, cell growth, and progressive degenerative in cells. So, developing NOX inhibitors has been thought to be promising treatment and published many small molecules. This review will focus on representative NOX inhibitors with their chemical properties, potency on NOX, mechanisms, and limitation of use as a drug.
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오도봉 ( Dobong Oh ),심승환 ( Seunghwan Shim ),최한고 ( Hango Choi ) 한국정보처리학회 2020 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.9 No.12
This paper proposes an augmented reality-based electronic circuit education system as a way for electronic circuit education, which is the basis of ICT convergence technology field. It consists of a hardware module that can identify the actual circuit and a mobile educational content that can check the current flow, input, output, and measured value by applying augmented reality technology. An experiment was conducted on image recognition, which is the main performance, for the purpose of stable operation of the system, and as the experimental method the recognition rate was measured by changing the distance between the hardware module and the mobile device to a certain interval. As a result of the experiment, the recognition rate was 100 percent at a distance of 25[Cm] or higher, and it was confirmed that the recognition rate decreased by 12% at a distance below 25[Cm], which can be said to be the effect of an error that results in image loss taken due to close distance. In the future, we plan to apply the education system presented in this paper to classes, which increases the efficiency of classes and improve students' interest and understanding of the subject.
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