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신희철,이향숙 대한교통학회 2006 대한교통학회지 Vol.24 No.3
O/D 추정을 위한 표본조사시 최소표본율의 결정은 조사 전체 및 구축된 O/D의 신뢰성과 직결되는 중요한 문제이다. 현재 대부분의 O/D 추정을 위한 교통조사시 정해진 기준 없이 단순히 전체 모집단에 대하여 정률로 표본율을 결정하거나, 모집단의 크기에 따라 약간씩 표본수를 가감하는 표본율을 사용하고 있으나, 적용시 신뢰성 문제가 존재하므로 이에 대한 보완이 필요하다. 본 연구에서는 이러한 문제점의 해결방안으로 최악의 경우에도 zero cell을 없애도록 고안된 교통조사지침의 표본수 결정식을 이용하되, 이 방법의 문제점인 과도한 표본율을 줄이기 위하여 카테고리수를 조사여건에 따라 차등 적용하여 예산제약의 문제를 해결하는 방안에 대하여 검토하였다. 전국 지역간 여객 O/D 자료를 대상으로 기존 O/D 자료에서 zero cell을 제외하는 경우(1안), 대권역으로 적용하는 경우(2안), 인접죤으로 통행하는 경우(3안), 다음 인접죤까지 통행하는 경우(4안) 등 4개 안을 제안하여 분석하였고, 그 결과 각 대안들은 신뢰성과 표본율 측면에서 대체관계(trade-off)로 각각 장단점을 내포하고 있는 것으로 나타났으므로, 각 조사기관은 조사의 신뢰성과 예산 등의 문제를 포괄적으로 고려하여 최적의 방법을 선택하여 적용하여야 할 것이다. A large sample can provide more information about the population. As the sample size increases, analysts will be more confident about the survey results. On the other hand, the costs for survey will increase in time and manpower. Therefore, determination of the sample size is a trade-off between the required accuracy and the cost. In addition, permitted error and significance level should be considered.Sample size determination in surveys for O/D estimation is also connected with confidence of survey result. However, the past methods were usually too simple to consider confidence. Therefore, a new method for O/D surveys was proposed and it was accurate enough, but it has too large sample size when we have current budget constraint.In this research, several minimum sample size determination methods for origin-destination survey under budget constraint were proposed. Each method decreased sample size, but has its own advantages. Selection of the sample size will depend on the study purpose and budget constraint.
신희철,이한별,유태경,이은신,김룡남,박보영,윤경아,박찬이,이은숙,문형곤,노동영,공선영,한원식 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an nextgeneration sequencing (NGS)–based multiple-gene panel containing 64 cancer-predisposing genes in Korean breast cancer patients with clinical features of hereditary breast and ovarian cancer syndrome (HBOC). Materials and Methods A total of 64 genes associated with hereditary cancer syndrome were selected for development of an NGS-based multi-gene panel. Targeted sequencing using the multi-gene panel was performed to identify germline mutations in 496 breast cancer patients with clinical features of HBOC who underwent breast cancer surgery between January 2002 and December 2017. Results Of 496 patients, 95 patients (19.2%) were found to have 48 deleterious germline mutations in 16 cancer susceptibility genes. The deleterious mutations were found in 39 of 250 patients (15.6%) who had breast cancer and another primary cancer, 38 of 169 patients (22.5%) who had a family history of breast cancer (! 2 relatives), 16 of 57 patients (28.1%) who had bilateral breast cancer, and 29 of 84 patients (34.5%) who were diagnosed with breast cancer at younger than 40 years of age. Of the 95 patients with deleterious mutations, 60 patients (63.2%) had BRCA1/2 mutations and 38 patients (40.0%) had non- BRCA1/2 mutations. We detected two novel deleterious mutations in BRCA2 and MLH1. Conclusion NGS-based multiple-gene panel testing improved the detection rates of deleterious mutations and provided a cost-effective cancer risk assessment.