태아(胎兒) 의 현사구체경화증(賢絲球體硬化症)

신희영 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.2

Since Herxheimer (1909) first described the presence of glomerulosclerosis in the kidney of newborn, there had been only a few reports on the glomerulosclerosis seen among fetuses and neonates. We are still not aware of the true incidence of glomerulosclerosis in fetuses, particularly among different age groups of the fetuses. The authors conducted a study to elucidate the fre- quency and possible cause of this condition. A total of 307 normal fetal kidneys were selected from autopsy specimens ranging in gestational age from 15 to 41 weeks. A large section covering entire midlon- gitudinal surface of each kidney was made for the microscopic examination. The glomerulosclerosis was not seen in fetuses before the gestational age of 26 weeks. It was first seen in fetuses in the age range of 26-27 weeks and then tended to increase steadily with the aging of the fetus, approaching near 50% by term. The sclerotic glomerui located mostly in the juxtamedullary portion of the cortex and was generally larger than the remaining uninvolved ones. The sclerotic glomeruli were characterized by thickening of the parietal layer of the Bowmans capsule and were associated with segmental and global sclerosis of the glomerular capillary tufts. Periglomerular lamellated fibrosis was also commonly seen among these glomeruli.

Effect of Process Parameters on the Angular Distribution of Sputtered Cu Flux in Long-Throw Sputtering System

신희영,김태호,박준우,손현철 대한금속·재료학회 2019 대한금속·재료학회지 Vol.57 No.7

In this work, the angular distribution of the sputtered Cu flux in a long throw sputtering (LTS) system is extracted from the comparison of experimentally-measured profiles of deposited films with simulated profiles of films in overhang contact structure. And effects of the sputtering process parameters such as Ar pressure during sputtering, RF power on substrates, and DC power on Cu target are investigated for a DC magnetron sputtering system with LTS. The bottom step coverage in contact is enhanced with decreasing operating pressure and is increased with increasing substrate RF power up to 200 W. However, the bottom step-coverage was reduced with substrate RF power above 400 W, possibly due to the re-sputtering effect of the deposited Cu films. DC power on Cu target does not affect the angular distribution of Cu atoms while the overall deposition rate is increased. Based on the estimated angular distribution of sputtered Cu flux, the profile of Cu film is deposition on a deep via of aspect ratio 10 and compared to the simulation of the film profile that shows a good agreement.

행정윤리에 대한 제한적인 윤리적 자연주의 접근

신희영 한국행정학회 2014 韓國行政學報 Vol.48 No.3

본 논문은 기존의 행정윤리에 대한 행정학 연구들이 공공행정의 도덕적 차원을 행정윤리에 대한 사회과학적 설명에서 잘 담아내지 못하고 있다는 문제의식에서 출발했다. 연구의 목적은 규범적인 행정윤리이론인덕윤리론, 의무론, 목적론(결과주의) 등을 비판적으로 재구성하고, 행정윤리 연구에서 ``제한적인 윤리적 자연주의 접근``이 갖는 함의가 무엇인지를 밝히는 것이다. 도덕철학의 윤리이론들은 자율적인 도덕적 주체로 인간을 상정하지 않으면 논의를 전개할 수 없다. 따라서 이러한 논의에서 인간 작인(인간의 의도적 인과성)의 인과적 지위를 허용하고 있는지를 비판적 실재론 입장에서 논의하였다. 경험적 실재론과 개념적 실재론(관념론)은 인간 작인의 인과적 지위를 유지 할 수 없다. 규범적 행정윤리이론에는 사실과 가치, 당위와 존재의 구분을 연결하는 문제가 가로 놓여있다. 제한적인 윤리적 자연주의는 비판적 설명 모델로 이 문제를 해결하고 있다. 제한적인 윤리적 자연주의는 규범적인 행정윤리이론과 사회과학적 설명을 연결하는데 강점을 가지고 있어서, 공공행정의 도덕성 속성을 사회과학적으로 연구하는데 도움을 준다.

Digoxin Toxicity in Patients with Elevated Digoxin Levels

신희영,박정수,임영채 한국자료분석학회 2006 Journal of the Korean Data Analysis Society Vol.8 No.6

A retrospective study of 2,709 serum digoxin concentrations assayed at Chonnam National University Hospital during 3-year period was conducted to determine the relationship between digoxin levels of 3.0 ng/ml or higher and digoxin toxicity. Clinical suspicion and creatinine clearance were found to be the significant risk factors for digoxin toxicity. Digoxin toxicity occurred less frequently than previously reported. Appropriately- timed sampling needs to be emphasized.

미세 색전 신호를 동반한 큰 동맥질환에서 확산강조영상의 병변 분석

신희영,김경문 대한신경과학회 2008 대한신경과학회지 Vol.26 No.1

Background: Microembolic signals (MES) are associated with the pathogenic mechanism of ischemic stroke with large-artery atherosclerotic disease. We examined the relationship between MES on a transcranial Doppler ultrasonography (TCD) and lesion patterns on diffusion-weighted MR imaging (DWI) in acute ischemic strokes associated with atherosclerotic diseases of the middle cerebral artery (MCA) and internal carotid artery (ICA). Methods: A total of 405 consecutive patients were monitored for MES within 48 hours of symptom onset. Patients with MES and DWI lesions in the territory of the MCA or ICA and corresponding MCA/ICA stenosis or occlusion on MR angiography (MRA) were included. MCA velocities and lesion patterns on DWI were compared. Results: MES were detected in 25 patients (MCA: 13, ICA: 12). The mean number of MES during 30 minutes of monitoring was 14.2±17.3 (range: 1-64, MCA: 13.9±13.6, ICA: 14.5±21.6, p-value=0.098). The mean flow velocity in the ipsilateral MCA in patients with MCA disease was higher than in patients with ICA disease (129.9±74.4 cm/s vs 61.1±28.2 cm/s, p=0.006). The frequency of multiple lesions on DWI was higher inpatients with ICA disease than in those with MCA disease (46.1% vs 100%, p=0.003). Conclusions: Multiple lesions on DWI were more frequent in ICA disease with MES than in MCA disease. Artery-to-artery embolism may be a more important stroke mechanism in acute ischemic stroke with ICA disease. Background: Microembolic signals (MES) are associated with the pathogenic mechanism of ischemic stroke with large-artery atherosclerotic disease. We examined the relationship between MES on a transcranial Doppler ultrasonography (TCD) and lesion patterns on diffusion-weighted MR imaging (DWI) in acute ischemic strokes associated with atherosclerotic diseases of the middle cerebral artery (MCA) and internal carotid artery (ICA). Methods: A total of 405 consecutive patients were monitored for MES within 48 hours of symptom onset. Patients with MES and DWI lesions in the territory of the MCA or ICA and corresponding MCA/ICA stenosis or occlusion on MR angiography (MRA) were included. MCA velocities and lesion patterns on DWI were compared. Results: MES were detected in 25 patients (MCA: 13, ICA: 12). The mean number of MES during 30 minutes of monitoring was 14.2±17.3 (range: 1-64, MCA: 13.9±13.6, ICA: 14.5±21.6, p-value=0.098). The mean flow velocity in the ipsilateral MCA in patients with MCA disease was higher than in patients with ICA disease (129.9±74.4 cm/s vs 61.1±28.2 cm/s, p=0.006). The frequency of multiple lesions on DWI was higher inpatients with ICA disease than in those with MCA disease (46.1% vs 100%, p=0.003). Conclusions: Multiple lesions on DWI were more frequent in ICA disease with MES than in MCA disease. Artery-to-artery embolism may be a more important stroke mechanism in acute ischemic stroke with ICA disease.

중대뇌동맥 영역의 급성 허혈성 뇌졸중 환자에서 경두개 초음파의 미세 색전과 확산강조영상에서 보이는 뇌경색 병변과의 관계

신희영,박광열,오형근,정진상,이광호,김경문 대한신경과학회 2006 대한신경과학회지 Vol.24 No.3

청소년의 학업-사회적 행동 프로파일 중심으로 살펴본 또래 지위와 학업 규범이 행동 발달에 미치는 영향

신희영 한국심리학회 산하 한국발달심리학회 2019 한국심리학회지 발달 Vol.32 No.2

Youth become increasingly concerned with their social status during early adolescence, and their social status is predictive of their academic and social functioning. The current study examined the longitudinal associations between two forms of social status(perceived popularity and social preference) and academic-social behavioral profiles, and the role of academic norms in behavioral development among early adolescents. Participants(N=736, 52% girls at W1, N=677, 52% girls at W2) evaluated the academic norms of their peers, and nominated peers for various academic and social behaviors as well as social status. Confirmatory factor analyses supported the two-factor structure of the behavioral profile: aggressive-disruptive and prosocial-engaged. Controlling for behavioral stability from W1 to W2, structural equation modeling indicated that the aggressive-disruptive behavioral profile at W1 positively predicted perceived popularity at W2. In addition, perceived popularity at W2 was positively associated with both aggressive-disruptive and prosocial-engaged behavioral profiles at W2, whereas social preference was negatively associated with the aggressive-disruptive behavioral profile but positively associated with the prosocial-engaged behavioral profile. Furthermore, youths’ academic norms at W2 were associated with an increased prosocial-engaged behavioral profile at W2. The current study underscores the importance of social status and peer norms in explaining adolescents’ behavioral development. 청소년은 또래 사이에서의 사회적 지위에 매우 민감하고, 또래 지위는 청소년의 학업 및 사회적 행동 발달에 매우 중요한 영향을 미친다. 또래 지위의 대표적인 두 지표로는 개인의 사회적인 영향력을 나타내는 지각된 인기도와 또래들 사이에서의 호감도를 나타내는 사회적 선호도를 들 수 있다. 본 연구는 청소년의 다양한 학업 행동 및 사회적 행동을 바탕으로 청소년의 학업-사회적 행동 프로파일을 탐색하고, 청소년의 학업-사회적 행동 프로파일이 또래 지위와 관련하여 어떠한 발달적 관계를 보이는지, 그리고 청소년의 학업 규범은 청소년의 행동 프로파일의 변화와 프로파일과 또래 지위의 관계에 어떠한 영향을 주는지 살펴보았다. 이를 위해 초등학교 5-6학년, 677-736명의 학생을 대상으로 자기 보고를 통해 학업 규범을, 또래 보고를 통해 개인의 또래 지위 및 학업 및 사회적 행동을 측정하였다. 탐색적 및 확인적 요인 분석을 통해 청소년의 다양한 학업 및 사회적 행동을 분석한 결과, 청소년의 행동은 공격적-비학업 행동과 친사회적-학업 행동의 2가지 행동 프로파일을 형성하는 것으로 나타났다. 구조 방정식 모형을 통해 청소년의 학기 초 행동이 학기 말 행동에 미치는 영향을 통제한 후 변인들의 관계를 살펴본 결과, 청소년의 학기 초 공격적-비학업 행동은 학기 말의 지각된 인기도를 높이는 것으로 나타났다. 또한, 지각된 인기도가 높은 청소년은 학기 말로 갈수록 높은 공격적-비학업 행동과 친사회적-학업 행동을 보인 반면, 사회적 선호도가 높은 청소년은 학기 말로 갈수록 낮은 공격적-비학업 행동과 높은 친사회적-학업 행동을 보이는 것으로 나타났다. 뿐만 아니라, 청소년이 또래의 학업 규범이 긍정적이라고 지각할수록 친사회적-학업 행동이 유의하게 증가하는 것으로 나타났다. 이러한 결과는 청소년의 행동 발달을 이해하기 위해, 또래 사이의 지위와 또래 규범을 종합적으로 고려해야 할 필요성을 시사한다.

연구위원장 사업계획-2009

신희영 한국정부학회 2009 Korean Association of Governmental Studies(KAGOS) Vol.21 No.1

Is the Neo-Marxian monopoly capital framework still valid?: Reviewing Foster and McChesney’s The Endless Crisis

신희영 경상대학교 사회과학연구원 2015 마르크스주의 연구 Vol.12 No.2

This review essay examines John Bellamy Foster and Robert W. McChesney’s recent book, The Endless Crisis: How Monopoly-Finance Capital Produces Stag- nation and Upheaval from the U.S.A. to China (New York: Monthly Review Press, 2012). The eruption of the global financial crisis and the ongoing ‘Great Recession’ worldwide requires a coherent Marxian theory that seeks to explain complex interactions between the real and financial sides of an economy in their historical and social contexts. Foster and McChesney suggest, in this connection, that Paul Sweezy and Paul Baran’s neo-Marxian analyses of American monopoly capitalism, initially proposed in the late 1940-1960s, are still valid for analyzing contemporary global economic phenomena. The two authors reappraise this neo-Marxian theme of monopoly capital and its prediction of the secular stagnation tendency in most advanced capitalist economies. They also claim that the increasing degree of financial bubble-bust cycles and various kinds of speculative activities that they call financialization is one of the most fundamental features of the monopoly stage of capitalism. After carefully reviewing their core arguments, however, the reviewer suggests that their theories of the relationship between monopoly capital and the secular stagnation tendency, the relationship between monopoly capital and the financialization, and the relationship between monopoly capital and changing nature of market competition still need further theoretical clarification and more empirical support.

임상시험심사위원회의 개선방안: 지속관리를 중심으로

신희영 대한임상약리학회 2011 Translational and Clinical Pharmacology Vol.19 No.1

As Korea has increasing number of clinical trials in recent years, institutional review boards (IRBs) are facing new challenges. The IRB should review submitted documents and supervise clinical trials from the beginning to the end to protect human subjects. Although most IRBs invest much time and efforts to initial review, they rarely conduct proper continuing management at the moment. The purpose of this article is to describe challenges involving continuing management, which includes unanticipated problems, subject's complaints, site visit, and continuing review, and to provide suggestions for improving it. Above all, institutions should perceive the importance of continuing management and they should provide sufficient manpower and resources for the management.