난관복원술후의 자궁외임신 빈도에 영향을 주는 인자들

신창재,황도영,김정구,장윤석,Shin, Chang-Jae,Hwang, Do-Yeong,Kim, Jung-Gu,Chang, Yoon-Seok 대한생식의학회 1990 Clinical and Experimental Reproductive Medicine Vol.17 No.2

To evaluate the factors affecting the incidence of ectopic pregnancy following tubal reversal, the clinical characteristics of ectopic pregnancy group (N=28)and intrauterine pregnancy group (N=316)were compared in 344 cases of pregnancy following tubal reversal using microsurgical technique at the Department of Obstetrics and Gynecolgy from July 1980 to May 1989. We found no significant relationship between the incidence of ectopic pregnancy and the duration of sterilization. Although the incidence rate (11.2%) of ectopic pregnancy following laparoscopic cautery appeared to be the highest among tubal sterilization methods, none showed statistically significant differences. There was a fourfold difference in the incidence rate of ectopic pregnancy between post-reversal tubal length less than 7cm (12.7%)and greater than 7cm (3.5%). The mean interval from tubal reversal to conception was 15.7months in ectopic pregnancy group, and 9. 3months in intrauterine pregnancy group, the difference reaching statistical significance. While most(80%)of the pregnancies were achieved within the first 12months following tubal reversal in intrauterine pregnancy group, 50% of the pregnancies occured in the same period, and the cumulative pregnancy rate is related in a linear fashion to the duration after reversal in ectopic pregnancy group. The incidence rate of ectopic pregnancy was found to be higher after cornual-ampullary anastomosis and cornual-isthmic anastomosis.

체외수정시술의 결과 예측지표로서의 자궁내막초음파술

신창재,김성수,Shin, Chang-Jae,Kim, Sung-Soo 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.1

Status of endometrium is a very important factor which influences the implantation of fertilized embryos. In this study, we evaluated the possibility that the endometrial depth and pattern assessed by vaginal sonography on the day of human chorionic gonadotropin (HCG) injection in in vitro fertilization (IVF) cycles could be used to predict the IVF outcome. A total of 112 cycles using gonadotropin releasing hormone agonist (GnRHa) for ovulation induction were evaluated. We classified all patients into group A(<9mm) or group B(${\geq}$ 9mm) according to endometrial depth, and into group l(hyperechogenic), group 2(isoechogenic) or group 3(hypoechogenic and triple line) according to endometrial pattern. The other classification was made considering both endometrial depth and pattern. There was no significant correlation between serum estradiol level and endometrial sonographic findings(depth and pattern)(p>0.05). The pregnancy rate of group A(31.3%) did not differ significantly from that of group B(43.7%), but no pregnancies were found in any patients with endometrial depth less than 6mm. The pregnancy rate was 40%, 35.7%, and 44.6 % for group 1, gorup 2, and group 3, respectively, but there was no statistically significant difference between these groups(p>0.05). In combined classification, there was a trend of higher pregnancy rate in case of endometrial depth greater than 9mm and hypoechogenic triple line pattern, but there was no statistically significant differences between these groups(p>0.05). The conclusion from the present data is that endometrial ultrasonography on the day of hCG administration had no predictive value for conception in IVF cycles.

인간정자의 수정능 부여 및 햄스터난자 침투에 영향을 주는 인자들에 관한 연구

신창재,김정구,문신용,이진용,장윤석 대한산부인과학회 1989 대한산부인과학회 학술대회 Vol.63 No.-

일반연제 발표 : 내분비 및 불임 ; 인간 정자의 수정능 부여 및 햄스터 난자침투에 영향을 주는 인자들에 관한 연구

신창재,장윤석 대한산부인과학회 1989 대한산부인과학회 학술대회 Vol.64 No.-

정상배란성 월경주기와 HMG 배란유도 월경주기의 혈중 Estradiol치의 지수 하수에 관한 연구

신창재(CJ Shin) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.12

1984년 6월부터 1985년 7월까지 서울대학병원 산부인과 불임상담실을 방문하여 남성인자로 인하여 치료를 받고 있는 정상 월경주기를 가진 환자 3명을 대상으로 혈중 E2치와 난소난포의 초음파검사를 실시하고, HMG와 HCG를 사용하여 배란유도가 시행된 무배란증경주기에서는 혈중 E2치가 최고치가 되었던 날을, HMG를 사용하여 배란을 유도한 월경주기에서는 HCG투여날을, 기준점 즉 0일로 하여 후향적 분석으로 다음과 같은 결과를 얻었다. 1.혈중 E2치를 반대수 눈금치에 표시해 본 결과 선상으로 표시되었으며 E2치의 회귀곡선을 E(t)=Aeλt 로 표시해 상관계수를 구한 결과 10명 모두에서 0.9이상으로 통계적으로 의미가 있었다. 2. 정상월경주기와 HMG유도월경주기에서의 E2치의 기울기는 Mann-Whitney-Wilcoxon 검정법에서 0.1수준에서도 유의하지 않아 서로 유사하다는 결론을 얻었다. 상기와 같은 연구결과로 도표 방법은 후속의 E2치를 예측하는데 있어서 유용한 방법으로 사료되 HMG/HCG를 사용하여 배란을 유도할 때 도표방법을 사용하면 E2측정의 횟수를 줄일 수 있는 유용 한 방법으로 배란 유도시에 사용할 수 있다. The accurate poediction adn detection of ovulation is important in the success of ovulation induction Especially in the monitoring of HMC- induced cycles close serial clinical and laboratory evaluations are necessary to optimize the results and minimize the adverse reactions Among these evaluation methods serum E2(estradilo) level is an improtant index of ovarian follicular growth in spontaneous and imduced cycles Recently the usefulness of the semilogarithmic plot of E2 has been described which may aid in the scheduling and possibly reduce the number of E2 sampling during monitoring of follicular growth This study was carried out to determing whether the semilogarithmic plot of serum E2 may be useful for estimating subsequent E2 concentration Wheher the slopes o serum E2 concentrations of HMG-induced cycles differ from those of serum E2 concentrations of normal cycles was also analyzed Serum E2 concentrations with ovarian follicular number and diameter by realtime sector scanner were evaluated in three patients who ovulated spontaneously and in seven patients whose ovulations were induced with HMG Semilogarithmic plots of estradilo concentrations(picograms per milliliter) versus time(days) were linear with slops ranging from 0.19 to 0.62 The rates of E2 production were similar during spontaneous and induced cycles.

성염색체 이상에 관한 세포유전학적 연구

신창재(CJ Shin) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.12

염색체 이상을 의심한 환자 156명에 대하여 말초혈액 임파구의 염색체 핵형분석을 실시하였다. 말초혈액의 배양 및 염색체 표본 작성은 macro method 또는 micro method를 이용하였다. 전체 환자 156명중 44.2%(69/156)에서 성염색체이상이 있었고, 염색체 이상 환자중 85.5%(59/69)가 수적인 이상이었으며, 14.5%(10/69)이 구조적 이상이었다. 구조적 이상에는 X-염색체의 역위형, iso-chromosome X, X-단완의 부분결함(XXp-), 기원을 알 수 없는 대상구조의 부가(XXq+)등과 기원이 분명치 않은 marker chromosome의 존재(45, X, +mar)등이 포함 되어 있다. 본 연구의 결과로 임상적으로 염색체 이상이 의심되는 환자에 대한 세포유전학적 연구는 매우 중요 함을 알 수 있다. Presented in this paper the date from a chromosome study of 156 patients referred sex chromosomal abnormalities. Karyotypes were obtained using short-term blood culture. Of these 87 patients had normal chromosome complements; 69(44.2%) patients had sex chromosome abnormality. Among all patients with chromosome abnormalities, 85.5%(59/69) had aberrations of sex chromosome number, the others 14.5%910/69) had aberrations of sex chromosome structure. Among the later, paracentric inversion of the long arm of X-chromosome, partial deletion of the short arm of X-chromosome and inrease in length of the long arm of X-chromosome were observed. Thus the results of the present study indicate the importance of cytogenetic evaluation in clinically abnormal patients.

β-Lactamase의 억제제가 β-Lactam계 항생제에 대한 항균효과 증진에 관하여

신창재,신규창 대한감염학회 1989 감염 Vol.21 No.1

Both amoxillin-clavulanic acid and ampicillin-sulbactam inhibitor combinations exhibited pronounced synergistic bacteriostatic and bacteriocidal effects compared to single drug on staphylococcus aureus and shigella flexneri which from β-lactamase and resistant to β-lactams. But methicillin and other β-lactam resistant staphylococcus formed no β-lactamase except one strain, and enzyme inhibitors showed no synergistic effects of these methicillin resistant strains. On the other hand, all salmonella species tested were β-lactamase negative and inhibitors worked rather antagonstic against some strains combined with β-lactams.

클래미디아 트라코마티스 감염

신창재(CJ Shin) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.11

N/A

한국인 임산부에 있어서 임신특속 기간에 따른 양수내 포도당농도치에 관한 연구

신창재(CJ Shin),라건영(KY Rha) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.3

Available biochemical parameters for the assessment of fetal maturity are still controversial . Since amniotic fluid glucose shows a progressive decrease with advancing gestational age, an investigation was done to see whether amniotic fluid glucose could be used as an index of fetal maturity. In 40 samples of amniotic fluid obtained from women at different gestational age, a relatively high degree of correlation was seen between gestational age and amniotic fluid glucose levels. Age, parity, and preclampsia did not have any effect on amniotic fluid glucose. While amniotic fluid glucose changes as the fetus matures , too much overlap in the values seen between the samples obtained before and after 37 weeks of gestation precluded its use as a clinically useful test of fetal maturity. It is suggested that the decrease observed in amniotic fluid glucose near term is related to the maturity of fetal kidney function.

생쥐 2-세포배아에 의한 시험관아기 배양용 대아제대혈청의 절적평가에 관한 연구

문신용,신창재,정구민,오선경,방명걸,장윤석,Moon, S.Y.,Shin, C.J.,Chung, K.M.,Oh, S.K.,Pang, M.G.,Chang, Y.S. 대한생식의학회 1989 Clinical and Experimental Reproductive Medicine Vol.16 No.2

The purpose of this study was to examine the qualitative variation of human fetal-cord sera (HCS) and to accept the sera in human lVF-ET program. One hundred and sixteenth RCS were tested with 1772 2-cell embryos of F1 (C57BL x CBA) virgin mice, Ten to sixteenth embryos were cultured in m-KRB medium with a aliquot of each serum (10%, v/v) or with bovine serum albumin(O.4%, w/v) as a control medium. Embryonic development were recorded at every 24hr for 4 days by such events as cellular compaction, cavitation, and hatching. In the control groups of eight assays, 98.1%(106/ 108) of 2-ce1l embryos developed above expanded blastocyst and the embryonic development was unified through the tests. But the developmental pattern in medium with each serum was various. Namely, the sera that supported development of 100% 2-cell embryos to above morula, early blastocyst, expanded blastocyst and hatching blastocyst was 45,7%(53/116) , 35.3%(41/116), 15.5%08/116.) and 6.9-%(8/116), respectively. And the sera that supported development of above 80% 2-cell embryos to the each embryonic stage was 92.2% (107/116), 83.6%(97/116), 63.8%(74/116) and 36.2%(42/116), respectively. Meanwhile two kinds of toxic pattern to the embryonic development were observed in some sera. The first pattern is that some sera arrested development of most embryos in pre- or post-stage of morula or blastocyst. The second pattern is that some sera promoted or arrested a part of embryos in the same dish. The ability of serum was depended on the batch of serum. Finally we could accept 69%(80/116) of the tested sera for human IVF-ET program. The base line for acceptance was the ability that supported above 80% 2-ce1l embryos to blastocyst. But some deterious sera were contained in this range. We cut off about 10% of the sera (83.6% , 97/116) that passed the baseline. This final percent of sera was similar to that of grade N of this study.