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Symposium 8-5 (SYP 8-5) : Antioxidant and vitamins in the management of vitiligo
신정현 ( Jeong Hyun Shin ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Vitiligo is a multifactorial disorder characterized by the appearance of white maculae that may spread over the entire body skin. Depigmentation is due to the loss of functioning melanocytes. The pathogenesis may involve multiple pathogenetic factors. Impaired antioxidative defences lead to accumulation of reactive oxygen species (ROS), which affect melanocytes. Mitochondrial membrane lipid peroxidation may participate to ROS overproduction. A temporal sequence may connect oxidative stress and autoimmunity. Overall, a genetic predisposition renders vitiligo melanocytes more susceptible to precipitating factors than normal healthy melanocytes. Therefore the most effective therapy should target all the etiologic factors. The current therapies mainly act by inducing immunosuppression and stimulation of melanocyte proliferation and migration. Other therapies, such as antioxidants which aimed to reduce oxidative stress, can be used in association with other therapeutic options.
폐암세포주에서 저용량 시스플라틴에 의해 유도된 자가포식
신정현 ( Jeong Hyun Shin ),장혜연 ( Hye Yeon Jang ),정진수 ( Jin Soo Chung ),조경화 ( Kyung Hwa Cho ),황기은 ( Ki Eun Hwang ),김소영 ( So Young Kim ),김휘정 ( Hui Jung Kim ),이삼윤 ( Sam Youn Lee ),이미경 ( Mi Kung Lee ),박순아 ( 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.1
Background: Most lung cancer patients receive systemic chemotherapy at an advanced stage disease. Cisplatin-based chemotherapy is the main regimen for treating advanced lung cancer. Recently, autophagy has become an important mechanism of cellular adaptation under starvation or cell oxidative stress. The purpose of this study was to determine whether or not autophagy can occurred in cisplatin-treated lung cancer cells. Methods: H460 cells were incubated with RPMI 1640 and treated in 5 μM or 20 μM cisplatin concentrations at specific time intervals. Cells surviving cisplatin treatment were measured and compared using an MTT cell viability assay to cells that underwent apoptosis with autophagy by nuclear staining, apoptotic or autophagic related proteins, and autophagic vacuoles. The development of acidic vascular organelles was using acridine orange staining and fluorescent expression of GFP-LC3 protein in its transfected cells was observed to evaluate autophagy. Results: Lung cancer cells treated with 5 μM cisplatin-treated were less sensitive to cell death than 20 μM cisplatin-treated cells in a time-dependent manner. Nuclear fragmentation at 5 μM was not detected, even though it was discovered at 20 μM. Poly (ADP-ribose) polymerase cleavages were not detected in 5 μM within 24 hours. Massive vacuolization in the cytoplasm of 5 μM treated cells were observed. Acridine orange stain-positive cells was increased according in time-dependence manner. The autophagosome-incorporated LC3 II protein expression was increased in 5 μM treated cells, but was not detected in 20 μM treated cells. The expression of GFP-LC3 were increased in 5 μM treated cells in a time-dependent manner. Conclusion: The induction of autophagy occurred in 5 μM dose of cisplatin-treated lung cancer cells.
에크린성 종양에 대한 임상 및 병리조직학적 소견 -대한피부과학회 피부병리 연구분과위원회 공동연구-
신정현 ( Jeong Hyun Shin ),고재경 ( Jai Kyoung Koh ),김광호 ( Kwang ho Kim ),김명화 ( Myung Hwa Kim ),김상원 ( Sang Won Kim ),김수남 ( Soo Nam Kim ),김시용 ( Si Young Kim ),김유찬 ( You Chan Kim ),손숙자 ( Sook Ja Son ),오지원 ( C 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
Background: Various eccrine tumors are rather common diseases in clinicians. However, data on the clinicopathologic features of eccrine tumors in Korea are limited. Objective: The purpose of this study was to investigate the clinicopathologic characteristics of eccrine tumors in Korea. Methods: Two hundred and sixty five cases of eccrine tumors, seen from 2002 to 2004 in Korea, were retrospectively analyzed clinically and histopathologically. Results: The most common eccrine tumors identified within Koreans were syringoma (61%), followed by eccrine poroma (13%), eccrine hidrocystoma (9%), and nodular hidradenoma (6%). Moreover, eccrine tumors were usually found to occur in middle-aged woman as multiple asymptomatic skin-colored papules. The most common site of occurrence was the face (45%), followed by the neck (9%), scalp (5%), foot (5%), abdomen (4%), and vulvar (3%). Conclusion: The results of this study will be useful and fundamental data on eccrine tumors for clinicians and pathologists. (Korean J Dermatol 2006;44(11):1273~1283)
태양광모듈의 전력 측정 개선을 위한 온도 보정법에 대한 연구
신정현(Jeong-Hyun Shin),이영석(Young-Seok Lee),이승재(Seung-Jae Lee),문종필(Jong-Fil Moon) 대한전기학회 2022 전기학회논문지 P Vol.71 No.2
Nowadays, solar energy is major energy source. New amount of solar system installation are estimated as about 200GW globally in 2021. Solar module has each original IV characteristics by the types of products. These informations contain Voc, Isc, Vmp, Imp, Pmax, F.F, Rs, Rsh and etc. These information reveal us voltage, current, power, resistance of PV module. Thus, precise measurement of IV characteristics of PV module is important for quality control, performance evaluation, and safety enhancement. In this paper, temperature compensation method is applied to PV module IV characteristics curve measurement under continuous solar simulator condition. These improved IV measurement method will attribute IV measurements of PV module easily and precisely.
The effect of rear side etching for crystalline Si solar cells
신정현(Shin, Jeong Hyun),김선희(Kim, Sun Hee),이홍재(Lee, Hongjae),김범성(Kim, Bum Sung),이돈희(Lee, Don Hee) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.06
Nowadays, the crystalline Si Solar cell are expected for economical renewable energy source. The cost of the crystalline Si solar cell are decreasing by improvement of its efficiency and decrease of the cost of the raw Si wafers for Solar cells. This Si wafer based crystalline Si solar cell is the verified technology from several decade of its history. Now, I will introduce one method that can be upgrade the efficiency by using simple and economical method. The name of this method is Rear Side Etching(RSE). The purpose of rear side etching is the elimination of n+ layer of rear side and increase of the flatness. The effects of rear side etching are the improvement of Voc and increase of efficiency by reducement series resistance and forming of uniform BSF. The experimental procedure for rear side etching is very simple. After anti-reflection coating on solar cell wafer, Solar cell wafer is etched by the etching chemical that react with only rear side not front side. This special chemical is no harmful to anti-reflection coating layer. It can only etched rear side of solar cell wafer. We can use etching image by optical microscope, minority carrier life time by WCT 120, SiNx thickness and refractive index by ellipsometer, cell efficiency for the RSE effect measurement. The key point of rear side etching is development of etching process condition that react with only rear side. If we can control this factor, we can achieve increase of solar cell efficiency very economically without new device.
신정현(Jeong Hyun Shin),조소연(Soyun Cho),황규광(Kyu Kwang Whang),함정희(Jeong Hee Hahm) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2
Ewing's sarcoma is a highly anaplastic, small round cell tumor, primarily arising in the intramedullary portion of the bone, and metastasis is common. Its origin is unknown. We describe a case of cutaneous metastatic Ewing's sarcoma in the pubic area in a 23-year-old female, who had been diagnosed as having Ewing's sarcoma of the pelvic bone three years ago, and treated by wide excision, chemotherapy and radiation therapy. Histopathologic examination of her nodular lesion revealed a tumor of small round cells whose membranes were positive for CD99. She was managed by conservative treatment but expired one month later. To our knowledge, Ewing's sarcoma metastatic to the skin has not been reported previously in the world. This case supports the neuroectodermal origin of this tumor and that cutaneous metastasis of this tumor is a hallmark of grave prognosis. (Korean J Dermatol 2000;38(2):249~253)