지표 개발을 통한 우리나라 교통 SOC 스톡의 국제비교

신의철,이재민(Lee, Jae-Min),심양주 대한교통학회 2004 대한교통학회 학술대회지 Vol.46 No.-

사회간접자본(SOC)은 교통, 통신, 전력 등 국가전체의 경제활동에 필요한 기반을 제공하는 공공시설로 정의되는데, 국가 예산상으로는 도로, 철도, 지하철, 공항, 항만 등 교통시설 외에 다목적댐, 치수, 용수사업을 SOC사업으로 분류하고 있다. 우리 경제의 경쟁력 강화를 위해서는 주요 사회간접자본 특히, 도로, 철도, 항만, 공항 등의 교통 인프라를 적기․적소에 공급하여 물류비용을 절감시켜 효율적인 생산 및 소비활동을 뒷받침해야 한다. 사회간접자본 부족을 타개하기 위한 정부 노력의 결과, 교통부문 SOC투자의 경우 2003년에 13.9조원으로 지난 5년간 32.7% 증가하였다. 그러나 이러한 교통부문 SOC 투자규모 대해서, 국가경제 규모에 비해 과잉 투자가 이루어지고 있으므로 줄여야 한다는 견해와 향후 일정기간 지속적으로 현재의 교통 SOC 투자가 유지되어야 한다는 견해가 대립되고 있는 실정이다.

우리나라 제 1,2종 법정전염병의 신고율 추정 및 신고 관련 특성 분석

신의철 가톨릭대학 (가톨릭신학대학) 대학원 1996 가톨릭大學醫學部 論文集 Vol.49 No.4

New Korean Record of Setarches longimanus (PISCES: Scorpaenidae)

신의철,김진구,주동수 한국수산과학회 2016 Fisheries and Aquatic Sciences Vol.19 No.2

Setarches longimanus (Alcock 1894), in the family Scorpaenidae, was collected from Busan and the coastal waters of Jeju Island,Korea,inJanuaryandNovember2014,respectively.TwospecimensarecharacterizedbyXI,10dorsalfinrays; 19–21pectoralfinrays; III, 5 anal fin rays; a second preopercular spine much shorter than the first and third; and an interorbital width 11.3 %–11.6 % of the standard length. We also analyzed 587 base pairs of the mitochondrial DNA cytochrome c oxidase subunit I sequences in order to confirm the taxonomic status of the specimen. As a result, the sequences of our specimen almost corresponded to those of Chinese S. longimanus (genetic distance, d = 0.005), but considerably differed from those of S. guentheri (d = 0.120–0.124). We propose the new Korean names “Ma-su-gampeng- sok” for the genus Setarches, and “Bul-geun-ma-su-gam-peng” for the species S. longimanus.

Modulation of the Surface Expression of CD158 Killer Cell Ig-like Receptor by Interleukin-2 and Transforming Growth Factor-B

신의철,최경선,김세종,신전수 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP

Killer cell Ig-like receptor (KIR) binds to HLA class I molecules on the surface of target cells, and it confers inhibitory signals to NK cells. Although NK cytotoxicity can be affected by the change of the surface expression of KIR on NK cells, the effect of cytokines on the regulation of KIR expression has not been thoroughly investigated. Here in our study, we investigated the effect of several cytokines, including IL-2, TGF-β, IFN-γ, IL-12 and IL-18, on the surface expression of CD158 KIR, which binds to HLA-C, by the use of FACS analysis. In the isolated NK cells, IL-2 obviously increased the surface expression of CD158 KIR after 72 hr in vitro culture, and this was evidenced by the increased percentage of CD158+ NK cells and the increased mean fluorescence intensity of CD158 in CD158+ NK cells. In contrast, TGF-β decreased the surface expression of CD158 KIR after 72 hr culture. However, IFN-γ, IL-12 and IL-18 did not change the expression of CD158 KIR. The modulated expression of KIR by IL-2 and TGF-β can be associated with the changed NK-cytotoxic target-discriminating ability of NK cells upon their exposure to IL-2 and TGF-β.

과테말라 Estancia de la Virgen지역 금-은-동-비스무스 광화대의 산상과 광물특성

신의철,김수영,홍세선,김인준 대한자원환경지질학회 1998 자원환경지질 Vol.31 No.6

The survey was carried out in order to deimeate the occurrence of ore deposits and the minderalized characteristics in the Estancia de la Virgen area through the 1:2,000 scaled geological mapping and topographic measuring surveys. Gold-silver mineralization is in the fault block developed between the San Agustin Fault and Cabanas Fault. It is associated with ore bearing quartz veins controlled by the fault structure. The contents of Au and Ag range from traces up to 72 g/t and 180 g/t respectively. Accordinf to traversing the outcrops, the quartz veins are traced by 0.5 ㎞ trended to north and south. In those extended part, they continue for 1,000 m intermittently. Gold-silver mineralization could be divided into three stages. In the first stage, pyrite, galena, sphalerite, and chalcolyrite were formed with the promary silver and gold associated with galena and copper sulfieds respectively. In the second stage, Cu-Bi-Au-Ag bearing sulfides such as chaleocite, covellite, and linarite are formed and usually deposited on the cataclastic fractures of galena and/or chalcopyrite. In the third stage, both the carbonation of galcna and sphalerite and the sulphatization of galena, took place in the surface environment. And then primary silver was carried away off and was deposited on galena and/or copper sulfides during oxidation near the water table. Low partitionings of Fe in sphalerite assist that the minerals were formed at the relatively low temperature, which is coincided with previously reported homogenization temperature of fluid inclusions.

의원급 의료기관의 자율적 인증제 개발

신의철,김경수,박성희,김지윤,이은환,김민지,임은진,김호종,박윤형,신현수 대한의사협회 의료정책연구소 2011 대한의사협회 의료정책연구소 연구보고서 Vol.- No.-

C형간염 바이러스: 면역과 HCV 백신

신의철 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.4(S)

Hepatitis C virus (HCV) infection is an issue of public health care. Chronic persistent HCV infection often progresses to liver cirrhosis and hepatocellular carcinoma. However, the current standard therapy shows a limited efficacy, and prophylactic vaccine has not been developed yet. Therefore, developments of a novel immunotherapy and effective HCV vaccine are urgent. In this lecture, characteristic features of antibody and T-cell responses will be discussed in chronic HCV infection. In addition, immune status after recovery from HCV infection will also be discussed. Understanding of immune responses against HCV will facilitate the development of effective therapeutic and prophylactic strategies.

인쇄전자 롤 수명 향상을 위한 고경도 Si-DLC 코팅 기술

신의철 한국표면공학회 2015 한국표면공학회 학술발표회 초록집 Vol.2015 No.5

Coalition Forces of Immunologists and Oncologists for Defeating Cancer

신의철,Deputy Editor, Immune Network 대한면역학회 2020 Immune Network Vol.20 No.1

There has been a long journey in the effort to harness the immune system for the treatment of cancer since Coley's toxin was first used to treat cancer 120 years ago. However, almost all efforts failed to improve patient outcomes. Meanwhile, the concept of cancer immunosurveillance and immunoediting has been established, and T cells have been considered major players in the immune responses to cancer. Moreover, immunologists have found that tumor antigen-specific T cells are largely ‘exhausted’ in both murine and human tumors. During immune responses, Ag-specific T cells are regulated by various mechanisms, including inhibitory receptors, to avoid excessive and persistent immune responses. These immune checkpoints suppress T-cell responses, particularly in cancer patients, leading to T-cell exhaustion. CTLA-4 and PD-1 are the most well-known immune checkpoint inhibitory receptors and have been targeted for drug development. As a result, anti-CTLA-4 and anti-PD-1/PD-L1 blocking antibodies are now successfully used for cancer treatment and known as immune checkpoint inhibitors (ICIs). The current ICIs have some limitations. First, ICIs fail to control tumors in a significant proportion of cancer patients. Moreover, tumor growth becomes accelerated after ICI treatment in some patients. This is known as hyperprogressive disease (HPD). In addition, certain patients suffer from immune-related adverse events (irAEs) following ICI treatment. However, we do not yet know the mechanisms underlying a non-response, HPD, and irAEs following ICI treatment, hampering mechanism-driven development of new immuno-oncological agents and rationale-based patient management. The recent explosive growth of ‘immuno-oncology’ has been enabled by successful translational research from bench-side basic immunology to bedside clinics. Now, it is time to raise questions from the bedside and answer them with basic immunology. These findings will then be translated to the clinic, creating a virtuous cycle to boost the growth of immuno-oncology. Coalition forces of immunologists and oncologists are necessary to defeat cancer. In the current issue of Immune Network, we publish 10 review articles in the field of tumor immunology and immuno-oncology. First, T-cell exhaustion and inhibitory receptors and co-stimulatory receptors are discussed. The roles of regulatory T cells, γδ T cells IL-17-producing cells, and NANOG signaling in tumor immunity are also described. From the translational and clinical aspect, peripheral blood biomarkers and irAE-related issues are comprehensively reviewed. The recent progress in immunotherapy for non-small cell lung cancer and hepatocellular carcinoma are discussed.

지불보상제도에 대한 체계적 분석, 고찰

신의철,이창우,김호종,남지현,박소정 대한의사협회 의료정책연구소 2014 대한의사협회 의료정책연구소 연구보고서 Vol.- No.-