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Taxonomic review of the Genus Caloptilia Hübner (Lepidoptera: Gracillariidae) in Korea
신영민,이봉우,변봉규 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.1
This study was conducted to review the genus Caloptilia in Korea with taxonomic arrangement. In this study, 19 species in the genus were recognized from Korea. Among them, four species, Caloptilia fidella (Reutti), C. hidakensis Kumata, C. illicii Kumata, and C. pulverea Kumata, are newly recorded in Korea. All the known species from Korea are briefly enumerated with illustrations of the adult and genitalic structures.
Microsporum canis에 의한 농창상 체부백선 1예
신영민,박소현,신동훈,최종수,김기홍 대한의진균학회 2006 대한의진균학회지 Vol.11 No.2
Microsporum(M.) canis is one of the zoophilic dermatophytes that is most likely transmitted by contact of infected animals. Cats are the principal reservoir for M. canis in Korea although with less frequency this fungus is also common in dogs. M. canis infections were mostly composed of tinea(T.) capitis, T. faciei and T. corporis. Clinical manifestations were single or multiple well-demarcated, annular shaped, erythematous scaly patches. But when the lesions were distorted by treatment, we should differenciate with other skin diseases. A 21 years old woman had multiple crusted, eroded or ulcerated lesions on the arms, trunk that look like ecthyma. And single lesion on the left chest showed scanty scaly lesion. M. canis was caltivated from the ecthyma like lesion and a cat of the patient. We report a patient with T. corporis by M. canis infection occurred to ecthyma like lesion after topical treatment for 3 months. Microsporum(M.) canis는 동물호성 (zoophilic) 피부사상균으로 동물과 접촉을 통해 사람에게 전염되며, 고양이가 주 감염원이다. M. canis는 1957년 서 등2에 의해 처음 보고었으나 1975년 이후 전국적으로 만연되어 현재는 두부백선과 체부백선의 중요한 원인균으로서 널리 토착화되고 있다. 임상적으로 주로 두부백선, 안면백선, 체부백선을 일으키며, 체부백선의 경우 주로 경계가 명확한 홍반성의 인설성 구진의 형태로 나타난다. 그러나 장기간 치료나 소파에 의해 원래의 모양과 다르게 변형되어 나타나는 경우 농창이나 농가진 등 다른 염증성 질환과 감별을 요한다. 저자들은 21세 여자에서 임상적으로 농창과 유사한 형태로 발생하여 치료가 지연되었던 M. canis 감염증 1예를 경험하고 비특이적인 모양으로 발생한 특이한 증례로 사료되어 보고한다.
조갑진균증의 진단에 있어 KOH 검사, 진균 배양 검사, 병리 조직 검사 및중합효소 연쇄반응의 비교
신영민,신동훈,최종수,김기홍,김극준 대한의진균학회 2007 대한의진균학회지 Vol.12 No.2
Background: Onychomycosis is one of the most common nail disorders, and it is necessary of mycologic confirmation to treat correctly. It has been reported that histopathologic evaluation and polymerase chain reaction (PCR) of the nail plate by nail clipping might be a useful supportive method for identification of causative fungi showing higher detection rates. Objective: This study was designed to compare diagnostic efficacy of KOH preparation, fungal culture, histopathologic examination and PCR in onychomycosis. Methods: Using 60 nail samples from 60 patients with clinically suspected onychomycosis, KOH preparation and fungal culture with nail and subungual tissue was performed. And histopathologic examination with PAS staining and PCR with DNA extracted from paraffin block was performed. Results: The results are summarized as follows: 1. The positive rates of conventional KOH preparation, fungal culture, histopathologic examination and PCR were 87.5%, 8.9%, 87.5% and 83.9%. 2. In histopathologic examination, fungi were distinguished as 3 groups based on Kim and Cho's classification (1997): dermatophytes, Candida sp. and non-dermatophytic mold (NDM). Fifteen of 49 samples are dermatophytes, 1 is Candida sp., and 7 are NDM, 8 are dermatophytes and Candida sp. mixed infections, 18 are dermatophytes and NDM mixed infections. 3. In PCR, 1 of 47 samples is Trichophyton rubrum, 4 are Candida sp. and 39 samples are NDM. Conclusion: Histopathologic examination in onychomycosis is considered to be an useful supportive method in diagnosis and identification of causative fungi in onychomycosis. [Kor J Med Mycol 2007; 12(2): 59-69]
신영민,김우진,김용수,조선영,박종석,권희정,임윤묵,노영창 한국방사선산업학회 2011 방사선산업학회지 Vol.5 No.2
A variety of natural polymers have been used as tissue engineering scaffolds, drug deliverysystem, and cosmetic materials due to their higher biocompatibility and water uptake. As amajor component of extracellular matrix, hyaluronic acid consisting of D-glucuronic acid and Nacetylglucosaminehas been popularly used as a hydrogel material. Even though it has good propertiesto be used in the tissue engineering and cosmetic industry, its higher viscosity has limited apotential use in a variety of applications; only low content should be applied in preparing aboveproducts. In the present study, we investigated the effect of electron beam irradiation on the propertiesof hyaluronic acid. Hyaluronic acid paste containing low contents of water changed tosolution after electron beam irradiation ranging from 1 to 10 kGy, which didn’t exhibit any alterationof surface properties and morphological change after freeze-drying. However, its viscositywas significantly decreased as absorbed dose increased, which was approximately one by hundredin comparison with the viscosity of original hyaluronic acid solution with same concentration. Inaddition, it can still interact with positive charged chitosan generating polyelectrolyte complex. Therefore, only viscosity was decreased after electron beam irradiation, whereas other propertiesof hyaluronic acid maintained. Consequently, these hyaluronic acids with lower viscosities can beused in a variety of applications in tissue engineering, drug delivery, and cosmetic industry.
신영민,김우진,박종석,권희정,노영창,임윤묵 한국방사선산업학회 2011 방사선산업학회지 Vol.5 No.4
The surface property of the materials used in tissue engineering application has beenessential to regulate cellular behaviors by directing their adhesion on the materials. To modulatesurface property of the synthetic biodegradable materials, a variety of surface modification techniqueshave used to introduced surface functional groups or bioactive molecules, recently polydopaminecoating method have been introduce as a facile modification method which can be coatedon various materials such as polymers, metals, and ceramics regardless of their surface property. However, there are no reports about the degree of polydopamine coating on the materials withdifferent hydrophilicity. In the present study, we prepared acrylic acid grafted nanofibrous meshesusing electron-beam irradiation, and then coated meshes with polydopamine. Polydopamine successfullycoated on the all meshes, both properties of acrylic acid and polydopamine were detectedon the meshes. In addition, the degree of polydopamine deposition on the materials has been alteredaccording to surface hydrophilicity, which was approximately 8-times greater than those on thenon-modified materials. In conclusion, dual effect from the acrylic acid grafting and polydopaminemay give a chance as a alternative tool in tissue engineering application.
신영민,정성인,권희정,정성인,임연묵,박종석 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.1
One of the interesting strategies for developingthe artificial blood vessels is to generate multi-layeredscaffolds for mimicking the structure of native blood vesselssuch as the intima, media, and adventitia. In this study, weprepared dual-layered poly(L-lactide-co-ε-caprolactone)(PLCL) scaffolds with micro- and nanofibers as a basicconstruct of the vessel using electrospinning methods,which was functionalized using a gelatin through acrylicacid (AAc) grafting by γ-ray irradiation. Based on themicrofibrous platform (fiber diameter 5 μm), the thicknessof the nanofibrous layer (fiber diameter 700 nm) wascontrolled from 1.1 ± 0.8 to 32.2 ± 1.7 μm, and the mechanicalproperty of the scaffolds was almost maintaineddespite the increase in thickness of the nanofibrous layer. The successful AAc graft by γ-ray irradiation could allowthe gelatin immobilization on the scaffolds. The proliferationof smooth muscle cells (SMC) on the scaffolds toward amicrofibrous layer was approximately 1.3-times greater thanin the other groups, and the infiltration was significantlyincreased, presenting a wide cell distribution in the crosssection. In addition, human umbilical vein endothelial cell(HUVEC) adhesion toward nanofibrous layer was wellmanagedover the entire surface, and the acceleratedproliferation was observed on the gelatin-functionalizedscaffolds presenting the well-organized gap-junctions. Therefore, our biomimetic dual-layered scaffolds may bethe alternative tools for replacing the damaged blood vessels.