Nortriptyline, a tricyclic antidepressant, inhibits voltagedependent K+ channels in coronary arterial smooth muscle cells

신성은,Hongliang Li,김한솔,김혜원,서미선,하권수,한은택,홍석호,Amy L. Firth,최일환,배영민,박원선 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2

We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not usedependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentrationdependent and state-independent manner independently of serotonin reuptake.

PEDOT:PSS로 코팅된 PLA 나노섬유 웹의 전기전도성 텍스타일 제조

신성은,차수진,조길수 한국의류산업학회 2020 한국의류산업학회지 Vol.22 No.2

We proposed a simple process of fabricating electroconductive textiles by coating conductive polymer PEDOT:PSS (Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)) on biocompatible PLA (Poly Lactic Acid) nanofiber web for application to smart healthcare. Electroconductive textiles were obtained by a drop-coating process using different amounts of PEDOT:PSS solutions., DMSO (dimethyl sulfoxide) was then used as an additive in the post-treatment process to improve conductivity. The surface morphology of the specimens was observed by FE-SEM. The chemical structures of the specimens were characterized using FTIR. The electrical properties (linear and sheet resistance) of the specimens were measured. The effect of the bending angles on the electrical properties was also investigated to confirm their applicability as wearable smart textiles. FE-SEM and FTIR analysis confirmed that the deposition of PEDOT:PSS on the PLA nanofiber web surface was successful. The conductivity of the PEDOT:PSS/PLA nanofiber web was enhanced up to 1.5 ml with an increasing amount of PEDOT:PSS solutions, but there was no significant difference at 2.0 ml. The optimum condition of PEDOT:PSS deposition was established to 1.5 ml. Even when the specimen coated with 1.5 ml was bent every 30°, the change in the electrical resistance values was still low within 3.7 Ω. It confirmed that stable electrical performance was maintained and proved the applicability as a flexible textile sensor.

영어교사의 과업중심 수업에 대한 인식과 활용

신성은,김해동 현대영어교육학회 2012 현대영어교육 Vol.13 No.1

The aim of this study is to identify English teachers' use of tasks and views on task-based language teaching (TBLT) within Korean ELT context. A total of 71 teachers participated in a questionnaire survey. Among them, 24 were working at primary and secondary schools and 47 were at private academy. And 35 were experienced and 36 were novice teachers with less than three years' teaching experience. The results of the analysis show that most of the respondents admitted the effectiveness of TBLT as a way of English teaching because it could contribute to meaningful learning and develop learners' English communicative competence. They thought that TBLT would be more appropriate for teaching speaking and listening rather than for reading and writing skills. Based on the findings, it is suggested that in order to generate learners' meaningful interactions and active involvements in an English classroom more various teaching tasks should be designed and provided for teachers.

『周易』에 내재한 종교성과 현대적 의의

신성수 동국대학교 동서사상연구소 2017 철학·사상·문화 Vol.0 No.23

종교성은 인간 본성의 중요한 부분을 이루고 있다. 고대인의 문화와 사유가 투영되어 있는 『주역』에는 인간의 종교적 심성이 반영되어 있다. 동양의 종교와 철학이 확립되기 이전에 형성된 『주역』은 인류의 보편적인 원형을 담고 있기 때문에 시대적 이념의 한계를 초월한다. 『주역』에는 인간의 삶에 관한 모든 것이 응축되어 있으며, 인류문화의 중심축 가운데 하나인 종교성이 깊이 배여 있다. 『주역』에 내재한 종교성을 제사(祭祀)와 신탁(神託)에 관한 종교문화와 신(神)과 신앙(信仰)에 관한 종교적 사유로 나누어 살펴보았다. 현대종교문화는 세속화와 종교다원성이라는 특징을 보여주고 있다. 특정 종교의 절대적인 권력과 권위를 거부하고 다른 종교와의 교섭이나 수용을 통하여 개인의 영성을 추구하는 새로운 변화를 보여주고 있다. 이러한 현상들은 조직화된 권력으로서의 종교라는 울타리를 벗어나, 진정한 인간으로서 신성(神性)과 영성(靈性)을 추구하고자 하는 새로운 변화로 볼 수 있을 것이다. 『주역』에 함유된 종교성은 현대 종교문화에서 새로운 가치를 보여주고 있다. 이것은 현대 인류가 지향해야 할 이상적 상태를 실현할 수 있는 길이기도 하다. Religion is an important part of human nature. The I-Ching (Book of Changes) in which the culture and thought of the ancients are projected reflects the religious mentality of human beings. Since the I-Ching which was formed before the establishment of oriental religions and philosophies, contains the universal prototype of mankind, and it transcends the limits of the ideology of the times. Everything about human life is condensed in the I-Ching and the religiosity which is one of the central axis of human culture is deeply embedded in it. The religiousness inherent in the I-Ching is divided into the religious culture about sacrificial rituals and trusts and the religious thinking about god and faith. Contemporary religious culture is characterized by secularization and religious pluralism. It shows a new change that rejects the absolute power and authority of a particular religion and seeks individual spirituality through the negotiation and acceptance with other religions. These phenomena can be seen as a new change to pursue divinity and spirituality as true human beings, escaping from the fence of religion as an organized power. The religiousness contained in the I-Ching shows new values ​​in contemporary religious cultures. This is a way to realize the ideal conditions that modern humanity should aim for.

고대 이집트의 종교와 예술

신성해(申性海) 원광대학교 인문학연구소 2005 열린정신포럼 발표자료집 Vol.2005 No.11

한국어 양태와 스페인어 서법의 대조 연구

신성은 한국언어유형론학회 2022 언어유형론연구 Vol.7 No.1

Korean is a language in which various modal expressions are used to indicate the possibility of realization of a proposition, and Spanish is a language in which one type of mood is used to express the same concept. Korean modal expressions and Spanish mood correspond to each other in that they represent the attitude or judgment of the speaker. It is confirmed not only theoretically, but also by a contrast analysis using discourse text. The contrast between Korean modal expressions and Spanish mood reveals characteristics of Korean modality, and it suggests that Spanish-speaking learners can use the difference as a reference when learning Korean modal expressions(107 words).

건물부문 온실가스 통합관리시스템 개발을 위한 타 부문 시스템 비교분석 연구

신성은,곽영훈,도화용,박진영,정영선 한국에너지학회 2016 한국에너지공학회 학술발표회 Vol.2016 No.4

토막이야기-인권 캠프를 해 봐요

신성국 우리신학연구소 2002 갈라진 시대의 기쁜소식 Vol.- No.563

분산형 DBMS와 클라이언트/서버형 DBMS

신성균 서강전문대학 1994 論文集 Vol.13 No.-

Modern computin aims at the Downsizing and the Distributing of applications and data. This trend results from the fact that compaines get intersets from the GUI-using software, but that they need more low-cost, efficienf and modernized micro-processor technology. Client/Server DBMS technology and distributing DBMS technology are those two principles that show possibilities to downsizing-related techonology.

남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이

신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.