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정명희,황석귀,김윤수,송정식 ( Myung Hee Chung,Suck Kuy Whang,Yoon Soo Kim,Chung Suk Song ) 생화학분자생물학회 1973 BMB Reports Vol.6 No.3
Twenty six oral lactose tolerance tests were performed in 21 healthy subjects and five patients. Each subjects were given 50gm of lactose in 300m1 of water. Venous blood sugar was measured at 0, 30, 60, 90 and 120 min. All 26 subjects showed a rise in blood sugar less than 25㎎ per 100㎖ (flat curve) above the fasting level. At least one or more of G. I. symptoms such as bloating, abdominal cramps and/or diarrheas were experienced by all subjects during and/or after the tests. Additional glucose and galactose tolerance tests performed in 3 subjects were normal and this excluded the possibility of absorptive defect in these individuals. In order to determine the lactase activity of the Korean adults, peroral mucosal suction biopsies were done in another 10 subjects who were randomly selected. In all the subjects, the activities of lactase were absent whereas those of sucrose were normal. The majority, if not all, of Korean adults are expected to have lactase deficiency.