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      • Cycloheximide가 취장 소화효소 활성에 미치는 영향

        김윤수,김명원,류용운,Kim, Yoon-Soo,Kim, Myung-Won,Ryu, Yong-Wun 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.2

        쥐에서 취장소화효소 활성은 식이조성에 대단히 예민하게 반응한다. 즉 정상 18% casein 식이 대신 5% casein 식이로 대체시 또는 5% casein 식이로 2-3주 동안 기른 쥐를 정상 18% casein 식이로 대체시 취장소화효소에 미치는 영향은 대단히 민감하게 반응하여 그 효소활성이 떨어지거나 다시 회복하였다. 또한 정상식이로 기른 쥐에게 단백질합성 억제 물질인 cycloheximide($1\;{\mu}g/gm$/체중 gm)를 1회 복강내 투여로 취장소화효소 chymotrypsinogen, trypsinogen 및 amylase는 그 활성이 심하게 저하되나 lipase는 전혀 영향을 받지 않았다. 5% casein 식이에 의하여 저하된 취장효소는 정상식이로 대체시 그 효소활성 회복이 빠르다. 그러나 정상식이로 대체전에 cycloheximide($1\;{\mu}g/gm$/체중 gm)를 복강내 투여후 정상식이로 대체하면 chymotrypsinogen, trypsinogen 및 amylase는 그 회복이 전혀 되지 않거나 정상식이로 대체전보다 더 떨어졌다. lipase는 cycloheximide처치에 관계 없이 같은 시간내에 정상치로 회복하였다. 이와 같은 실험 결과는 이들 취장효소는 동일쥐의 취장세포에 존재하는 효소들이지만 cycloheximide에 의한 효소활성이 달리 반응하는 결과로 미루어 적어도 lipase 만은 그 생합성 과정이 다른 소화효소와 다름을 시사한다. These experiments were designed to assess the dietary-induced depletion and repletion of pancreatic enzymes mediating the adaptation of rat pancreas to the substitution of 5% casein diet for a normal diet of 18% casein and the substitution of 18% casein normal diet for a 5% casein diet which causes the pancreatic enzymes of chymotrypsinogen, trypsinogen, amylase and lipase to decrease remarkably during the 2~4 weeks feeding period. Pancreatic chymotrypsinogen, trypsinogen and amylase of the rat's (feeding) normal diet were severely depressed by one dose of intraperitoneal injection of cycloheximide ($1\;{\mu}g/gm$ of body weight) which is believed to be a specific inhibition of peptide bond formation. However, lipase was not affected at all by this treatment. The pancreatic enzymes of the rat fed with 5% casein diet for 4 weeks were depressed but when the 5% casein diet was substituted to a 18% casein diet the repletion of pancreatic enzymes was remakable. However, the repletion of chymotrypsinogen, trypsinogen and amylase was prevented or even more depressed when $1\;{\mu}g/gm$ of body weight of cycloheximide was injected intraperitoneally, daily during the period of 18% normal casein diet feeding. The only exception was lipase which recovered to normal enzyme level in the same as noncyclohe ximide treated rats. These results indicate that the enzymatic repletion and depletion of the pancreatic enzymes in the diet are not similar to each other and are entirely different in the case of lipase, even though these pancreatic enzymes are found in identical tissues of the rat.

      • KCI등재

        Foreign Ownership of Banks and Its Effect on Bank Performance: The Case of Korea

        김윤수 한국학술연구원 2005 Korea Observer Vol.36 No.2

        This study investigates the impact of foreign-controlled banks on the profitability and efficiency of domestic banks in Korea, as well as the effect of the level of foreign ownership on local bank performance. Increased market penetration by foreign-controlled banks reduces the net interest margin and profitabil-ity of domestic banks while increasing their opera-tional efficiency through reduced overhead cost. In addition local banks with greater foreign ownership were found to be less profitable than those with smaller foreign ownership.

      • SCOPUSKCI등재

        과초산(過酢酸)에 의한 독일가문비나무의 탈리그린화의 적정조건

        김윤수 한국목재공학회 1984 목재공학 Vol.12 No.5

        The delignification with peracetic acid in spruce wood (Picea abies Karst)were investigated on the variation of reaction time, temperature and the concentration of peracetic acid (PA). Holocellulose, acid-insoluble lignin in the holocellulose (=residual lignin), the content of alpha-cellulose and polyose fractions A and B were determined. The higher the reaction temperature and the concentration of PA and the longer the reaction time, the more the delignification with PA were accelerated, whileas the treatment at temperature lower than 54℃ resulted in a poor delignification. The content in alpha-cellulose and residual lignin depended on the degree of delignification. The yield of polyoses was, however, mostly unrelated to the conditions of delignification. The losses of mannan and xylan reached 30-40℃ during the reaction. Considering the content of residual lignin and polysaccharide, the following reaction condition may he suitable for the delginification test in laboratory, 5% of PA, 90℃ for 1 hr or 10%, 70℃ 2 hrs.

      • KCI등재

        Effectiveness of Temporal Augmentation Using a Calvarial Onlay Graft during Pterional Craniotomy

        김윤수,이형석,김한규,한예식 대한성형외과학회 2016 Archives of Plastic Surgery Vol.43 No.2

        Temporal hollowing occurs to varying degrees after pterional craniotomy. The most common cause of temporal hollowing is a bony defect of the pterional and temporal regions due to the resection of the sphenoid ridge and temporal squama for adequate exposure without overhang. The augmentation of such bony defects is important in preventing craniofacial deformities and postoperative hollowness. Temporal cranioplasty has been performed using a range of materials, such as acrylics, porous polyethylene, bone cement, titanium, muscle flaps, and prosthetic dermis. These methods are limited by the risk of damage to adjacent tissue and infection, a prolonged preparation phase, the possibility of reabsorption, and cost inefficiency. We have developed a method of temporal augmentation using a calvarial onlay graft as a single-stage neurosurgical reconstructive operation in patients requiring craniotomy. In this report, we describe the surgical details and review our institutional outcomes. The patients were divided into pterional craniotomy and onlay graft groups. Clinical temporal hollowing was assessed using a visual analog scale (VAS). Temporal soft tissue thickness was measured on preoperative and postoperative computed tomography (CT) studies. Both the VAS and CT-based assessments were compared between the groups. Our review indicated that the use of an onlay graft was associated with a lower VAS score and left-right discrepancy in the temporal contour than were observed in patients undergoing pterional craniotomy without an onlay graft.

      • SCOPUSKCI등재

        한국산 유용목재의 기초재질에 관한 연구

        김윤수,이정석,정병재 한국목재공학회 1978 목재공학 Vol.6 No.2

        Five species, Abies koreana Wilson (A, koreana), Castanopsis cuspidata var. Sieboldii Nakai (C. Cuspidata), Machilus thunbergii Sieb. et Zucc.(M. thunbergii), Styrax japonica (S. japonica), and Quercus acuta Thurberg(Q. acuta) growing in the southern part o Korea were selected for the investigation of wood properties. In order to evaluate the wood properties of these five species, anatomical, physical, mechanical, chemical and pulping characteristics were investigated. And this study also covered wood technological problems related to the drying, gluing, debarking, flooring, and wood workability so that these species might serve to the best advantage. The results obtained were summarized as follows: 1. The trunk of A. koreana with many knots was straight. However, the trunks of S. japonica and C. cuspidata were crooked. 2. A. koreana showed the longest and the widest in the fiber morphology; 2.97mm in length, 39.3μ in width. In several, fiber width of all the species investigated were greater than those of other Korean hardwoods. 3. The specific gravity of Q. acuta was 0.74±0.03, and that of A. koreana was 0.34±0.02. The range of specific gravity of the other species was 0.47-0.52. 4. The adsorption of water was propotioned inversely with the specific gravity, but the adsorption of humidity was proportioned with the specific gravity. In spite of their medium density, S. japonica showed the greatest adsorption, and M. thunbergii the least. The water adsorption of cross section was twice greater than that of lateral direction, and there was a slight difference in between the radial and the tangential direction. 5. Shrinkage for tested five species was ranged from 5.36 to 10.24% in tangential direction and 2.83∼6.13% in radial direction. Q. acute recorded the greatest shrinkage rate, and A. koreana the 1east. The greater was the specify gravity, the larger was the shrinkage rate. 6. The mechanical properties of Q. acuta were similar to those of Quercus mongolica which grow in Kangwon-Do. Strength properties of C. cuspidata, M. thunbergii, A. koreana were equivalent to those of other Korean commercial woods with similar specific gravity, except S. japonica which showed slightly higher strength than that of other species with similar density. 7. Higher glue joint strength for urea and phenol adhesieves was recorded in the species of M. thunbergii and C. cuspidate, however, high-density species (Q. acuta) and even low-density species(A. koreana) did not show good joint strength. 8. The attractive figure of M. thunbergii in texture seemed to be appreciated for decoration. And the grain and texture of other species were proper for furniture and building materials. 9. All of the species except Q. acuta were considered good for wood workability. 10. The denser the specific gravity was, the longer the drying time took. However, severe drying, defects were formed in M. thunbergii whose density was medium. 11. All the species were considered suitable for the flooring wood expect A. koreana whose density was light. 12. Pentosan component in all the species was great, and the amount of extractives in Q. acuta was worth noticing. 13. Yieid in kraft pulp was above the lever of economic pulp yield, i.e. 45% in all species. 14. Debarking was easy in the species of A. koreana and M. thunbergii, and debarking after being broiled in water was the most efficient in all species.

      • SCOPUSKCI등재

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