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송용상,전혜원,이재훈,김재원,박창수,박노현,박충학,강순범,이효표 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.2
Twenty two patients with primary invasive carcinoma of the vulva were treated at Seoul National University Hospital from 1980 to 1991 and their clinicopathological profiles were analyzed retrospectively. The median age of the patients was 50 years(32-81 years). The most frequent presenting symptom was a palpable lump or mass observed in 14 patients(63.6% ), followed by pruritis in 12 patients(54.5% ) and pain in 10 patients(45.5%). As a standard therapy, radical vulvectomy with bilateral inguinofemoral lymphadenectomy was performed in 17 patients and simple vulvectomy was done in one patient. Eight patients of them had reconstructive surgery with local cutaneous(5 patients) or myocutaneous(3 patients) flaps. Chemotherapy or radiotherapy was performed in 3 patients and one patient rejected the treatment. Nineteen patients(86.4%) had squamous cell carcinoma, 2(9.1%) had adenocarcinoma of the Bartholins gland, and one(4.5%) had melanama. of 18 surgically treated patients, 5 were stage I (27.8%), 7 were stage 11(38.8%), 2 were stage Ill(11.1%), 3 were stage Wa(16.7k) according to FOGO surgical staging, and one had melanoma of Clark's level IV. Two(11.1% ) of them had lymph node metastasis There was no caw of primary mortality but morbidity was observed in 16 patients(88.9%). The 5 year survival rate of 18 surgically treated patients was 65.3%(median follow--up 47 months). This experience suggests that more conservative surgery should be considered in the management of selected patients with primary invasive vulvar cancer.