Antibiotic Resistance Mechanisms of Escherichia coli Isolates from Urinary Specimens

송성욱,이은영,고은미,하호성,정호중,배일권,정석훈 대한진단검사의학회 2009 Annals of Laboratory Medicine Vol.29 No.1

Background : This study was designed to characterize urinary isolates of Escherichia coli that produce extended-spectrum β-lactamases (ESBLs) and to determine the prevalence of other antimicrobial resistance genes. Methods : A total of 264 non-duplicate clinical isolates of E. coli were recovered from urine specimens in a tertiary-care hospital in Busan in 2005. Antimicrobial susceptibility was determined by disk diffusion and agar dilution methods, ESBL production was confirmed using the double-disk synergy (DDS) test, and antimicrobial resistance genes were detected by direct sequencing of PCR amplification products. E. coli isolates were classified into four phylogenetic biotypes according to the presence of chuA, yjaA, and TSPE4. Results : DDS testing detected ESBLs in 27 (10.2%) of the 264 isolates. The most common type of ESBL was CTX-M-15 (N=14), followed by CTX-M-3 (N=8) and CTX-M-14 (N=6). All of the ESBLproducing isolates were resistant to ciprofloxacin. PCR experiments detected genes encoding DHA- 1 and CMY-10 AmpC β-lactamases in one and two isolates, respectively. Also isolated were 5 isolates harboring 16S rRNA methylases, 2 isolates harboring Qnr, and 19 isolates harboring AAC(6’)- Ib-cr. Most ESBL-producing isolates clustered within phylogenetic groups B2 (N=14) and D (N=7). Conclusion : CTX-M enzymes were the dominant type of ESBLs in urinary isolates of E. coli, and ESBL-producing isolates frequently contained other antimicrobial resistance genes. More than half of the urinary E. coli isolates harboring CTX-M enzymes were within the phylogenetic group B2. Background : This study was designed to characterize urinary isolates of Escherichia coli that produce extended-spectrum β-lactamases (ESBLs) and to determine the prevalence of other antimicrobial resistance genes. Methods : A total of 264 non-duplicate clinical isolates of E. coli were recovered from urine specimens in a tertiary-care hospital in Busan in 2005. Antimicrobial susceptibility was determined by disk diffusion and agar dilution methods, ESBL production was confirmed using the double-disk synergy (DDS) test, and antimicrobial resistance genes were detected by direct sequencing of PCR amplification products. E. coli isolates were classified into four phylogenetic biotypes according to the presence of chuA, yjaA, and TSPE4. Results : DDS testing detected ESBLs in 27 (10.2%) of the 264 isolates. The most common type of ESBL was CTX-M-15 (N=14), followed by CTX-M-3 (N=8) and CTX-M-14 (N=6). All of the ESBLproducing isolates were resistant to ciprofloxacin. PCR experiments detected genes encoding DHA- 1 and CMY-10 AmpC β-lactamases in one and two isolates, respectively. Also isolated were 5 isolates harboring 16S rRNA methylases, 2 isolates harboring Qnr, and 19 isolates harboring AAC(6’)- Ib-cr. Most ESBL-producing isolates clustered within phylogenetic groups B2 (N=14) and D (N=7). Conclusion : CTX-M enzymes were the dominant type of ESBLs in urinary isolates of E. coli, and ESBL-producing isolates frequently contained other antimicrobial resistance genes. More than half of the urinary E. coli isolates harboring CTX-M enzymes were within the phylogenetic group B2.

회원작품 - 건축비평 _ 라티스 빌딩 2 in 1

송성욱,Song, Sungwook 대한건축사협회 2021 建築士 Vol.627 No.-

응급실을 방문한 급성 폐색전증 환자의 예후 예측에 있어서 전산화 단층촬영 혈관 조영술의 정량적 분석의 유용성에 관한 연구

송성욱,박진식,제환준,이현주,박은아,신상도,정성구,곽영호,서길준 대한응급의학회 2009 大韓應急醫學會誌 Vol.20 No.1

Purpose: We evaluated the usefulness of quantitative analysis of computed tomography (CT) pulmonary angiography as a predictor of the prognosis of acute pulmonary embolism (PTE). Methods: We performed a retrospective analysis of 55 patients who visited our emergency department from January 2000 to November 2007 who were confirmed with PTE by CT pulmonary angiography. Two radiologists blinded to patient outcome measured CT parameters including the diameter of vessels and chambers, and the quantified pulmonary artery (PA) clot load score on the basis of embolus size and location. CT parameters and other clinical predictors were analyzed to determine their ability to predict major adverse event (MAE). Results: Of the 55 patients, 16 (29.1%) had a MAE PTE related shock, intubation, death, thrombolysis, right ventricular (RV) dysfunction within 30 days). Geneva score (odds ratio 2.5, 95% CI 1.18-5.29, p=0.02) and PA clot load score (odds ratio 1.64, 95% CI 1.18-2.27, p<0.01) were strong independent predictors of MAE. The cut-off value of Geneva and PA clot load scores were 4.5 and 19.0, respectively, and the area under the ROC curve were 0.697 (0.546~0.848) and 0.908 (0.828-0.988), respectively. Conclusion: Geneva and PA clot load score are significant predictors of PTE related shock, intubation, death, thrombolysis, and RV dysfunction within 30 days. CT pulmonary angiography is a useful predictor for the prognosis of PTE as well as a useful diagnostic tool.

Severe Fever with Thrombocytopenia Syndrome Mimicking Scrub Typhus: Three Case Reports

송성욱,유승진,유정래,이근화,김재왕,허상택 대한응급의학회 2015 大韓應急醫學會誌 Vol.26 No.4

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in South Korea with clinical features similar to those of scrub typhus. Infected patients with these two diseases usually visited the emergency department (ED) complaining of fever that was not responsive to treatment in a local clinic. Aggressive management of SFTS is required in order to prevent rapid progression and human-to-human transmission, thus rapid and accurate differential diagnosis of the two diseases in the ED is important. We reported three laboratory confirmed cases of SFTS during 2013-2014 in a single center, with fever, skin lesions, and history of outdoor activities in order to help in differential diagnosis between SFTS and scrub typhus in the ED.

Expanded Implementation of Prehospital 12-ECG and Overcoming Obstacles

송성욱 대한응급의학회 2023 대한응급의학회 학술대회초록집 Vol.2023 No.2

<홍길동전> 이본신고

송성욱 서울대학교 국어국문학과 1988 冠嶽語文硏究 Vol.13 No.1

Microplate Fixation without Maxillomandibular Fixation in Double Mandibular Fractures

송성욱,범진식,강상윤,양원용 대한두개안면성형외과학회 2014 Archives of Craniofacial Surgery Vol.15 No.2

Background: Maxillomandibular fixation (MMF) is usually used to treat double mandibularfractures. However, advancements in reduction and fixation techniques mayallow recovery of the premorbid dental arch and occlusion without the use of MMF. Weinvestigated whether anatomical reduction and microplate fixation without MMF couldprovide secure immobilization and correct occlusion in double mandibular fractures. Methods: Thirty-four patients with double mandibular fractures were treated with openreduction and internal fixation without MMF. Both fracture sites were surgically treated. For bony fixations, we used microplates with or without wire. After reduction, eachfracture site was fixed at two or three points to maintain anatomical alignment of themandible. Interdental wiring was used to reduce the fracture at the superior border andto enhance stability for 6 weeks. Mouth opening was permitted immediately. Results: No major complications were observed, including infection, plate exposure,non-union, or significant malocclusion. Five patients experienced minor complications,among whom the only one patient experienced a persistant but mild malocclusion withno need for additional management. Conclusion: This study showed that double mandibular fractures correction with twoorthree-point fixation without MMF simplified the surgical procedure, increased patientcomfort, and reduced complications, due to good stability and excellent adaptation

필사본 <임화정연> 72책본 텍스트 연구 ― 구활자본과의 비교를 중심으로 ―

송성욱 서울대학교 규장각한국학연구원 2005 한국문화 Vol.36 No.-

The “Limwhajungyoen(林花鄭延)” is one of the best known novel in the later Chosun. We have known that “Limwhajungyoen” exists only as the printed matter which is published by old-print in the earlier 20C. This is a different book than the original. This book is printed by reduced the context of the original work. Therefor, We are concerned about the real figure of the “Limwhajungyoen”. Recently anyone what is so called Kangchonje 江村齋 happen on a another “Limwhajungyoen”. The new “Limwhajungyoen” is in 72 volumes, which is not printed but transcript. This is rich in the context than the printed matter. This paper make a comparative study the transcript of the printed.

조선시대 장편소설과 단편소설의 거리

송성욱 성심어문학회 1999 성심어문논집 Vol.20ㆍ21합병 No.-

대하소설과 남녀 애정 문제 - 소설사적 흐름을 중심으로 -

송성욱 성심어문학회 2002 성심어문논집 Vol.24 No.-