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송달원 啓明大學校 醫科大學 1999 계명의대학술지 Vol.9 No.4
Tuberculous cervical lymphadenitis remains a diagnostic and therapeutic challenge because it mimics other pathalogic processes, and because of inconsistent reliability of physical and labaratory findings. 17 cases of tuberculous cervical lymphadenitis were treated and analyzed at the Department of Otolaryngology, Keimyung University Hospital from Jan. 1986 through Dec. 1989. The results were as follows, 1) Most common age and sex were 20∼40 years, female. 2) Associated pulmonary tuberculosis was exhibited by 6 cases(35%). 3) 7 patients(41%) had abscess formation in the infected nodes and surrounding deep neck space. 4) Associated head and neck lesions were tonsil, middle ear and external ear canal, parotid gland, larynx and pharynx. 5) Histologic examination of the excisional biopsy was most reliable test for confirm the diagnosis. 6) 14 out 17 cases had surgical intervention for I & D and excision of nodes. 7) All patients were subsequently treated with 8∼18 months of antituberculous chemotherapy and had a good results without complication except 1 case recurrence.
송달원,남성일 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.7
Primary lymphoma of the thyroid is a relatively rare malignant thyroid neoplasm. It is known to be frequently associated with Hashimotos thyroiditis. The clinical presentation includes an enlarging neck mass, accompanied by dysphagia, dyspnea or hoarseness, with its most common histologic type being the diffuse large B cell non-Hodgkins lymphoma. Recently, we experienced a case of a primary thyroid lymphoma associated with Hashimotos thyroiditis in a 60-year-old woman, who presented with an anterior neck mass. We present this case with a review of the literature.
宋達源 啓明大學校 醫科大學 1985 계명의대학술지 Vol.4 No.2
著者가 경험한 2例에서는 放射線治療後 약 3~4개월부터 심한 喉頭浮腫 및 呼吸障碍와 壞死로 인한 疼痛 등을 호소하여 喉頭機能損失로 판정하고 手術的으로 喉頭를 除去해야 했던 患者에서 재건된 咽頭粘膜의 破裂로 皮瘤로 통하는 瘻孔을 가져오게 되어 보건적 치료 및 재건술에 의해 치료에 효험을 보았기에 문헌을 고찰하여 보고하는 바이다. Postradiation laryngeal edema may occur when either high doses have to be given or infection supervenes on an irradiated larynx. In our dept., I had experienced patients with the glottic and transglottic type of laryngeal cancer, who had selected radiotherapy with Cobalt 60, as a first choice. The partients had showed severe edema around the arytenoid and suffered from dyspnea and neck pain 3 to 4 months after radiotherapy. In spite of repeated trials with antibiotics and steroid, there were no improvement. So, total laryngectomy were performed. After operation I had experienced the complications of pharyngocutaneous fistula and disruption of the reconstru-cted pharyngeal mucosa. Hereby I present 2 cases with a brief review of the literature.
송달원,김동은,신승진,정승곤,이강대 대한이비인후과학회 2008 Clinical and Experimental Otorhinolaryngology Vol.1 No.2
Objectives. The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this study is to detect MAGE and SSX gene transcripts of head and neck cancers using the MAGE 1-6 assay and the SSX 1-9 assay. Methods. The transcripts of MAGE 1-6 and SSX 1-9 genes were detected by the MAGE 1-6 assay and the SSX 1-9 assay respectively, in cancer cell lines, cancer tissue, and induced sputum specimens from head and neck cancer patients. Results. The transcripts of MAGE 1-6 and SSX 1-9 genes were detected in 82.8% and 75.9% of head and neck cancer tissues (N=29) respectively, and 96.6% of cancer tissues expressed at least one of MAGE 1-6 or SSX 1-9 genes. In the induced sputum of head and neck cancer patients (N=18), the transcripts of MAGE 1-6 and SSX 1-9 genes were detected in 72.2% and 77.8%, respectively, and 94.4% of the sputum specimens were positive for either the MAGE 1-6 or the SSX 1-9 assay. Conclusion. These results suggest that the combination of MAGE 1-6 and SSX 1-9 assays may be useful in the diagnosis of head and neck cancer. Objectives. The melanoma antigen gene (MAGE) and synovial sarcoma on X chromosome (SSX) gene families are silent in most normal adult tissues, but are expressed in a variety of malignant lesions. Therefore, detection of MAGE and SSX transcription may be useful for the diagnosis of head and neck cancers. The aim of this study is to detect MAGE and SSX gene transcripts of head and neck cancers using the MAGE 1-6 assay and the SSX 1-9 assay. Methods. The transcripts of MAGE 1-6 and SSX 1-9 genes were detected by the MAGE 1-6 assay and the SSX 1-9 assay respectively, in cancer cell lines, cancer tissue, and induced sputum specimens from head and neck cancer patients. Results. The transcripts of MAGE 1-6 and SSX 1-9 genes were detected in 82.8% and 75.9% of head and neck cancer tissues (N=29) respectively, and 96.6% of cancer tissues expressed at least one of MAGE 1-6 or SSX 1-9 genes. In the induced sputum of head and neck cancer patients (N=18), the transcripts of MAGE 1-6 and SSX 1-9 genes were detected in 72.2% and 77.8%, respectively, and 94.4% of the sputum specimens were positive for either the MAGE 1-6 or the SSX 1-9 assay. Conclusion. These results suggest that the combination of MAGE 1-6 and SSX 1-9 assays may be useful in the diagnosis of head and neck cancer.