기저핵, 시상, 속섬유막 뇌출혈로 인한 반신부전마비에 대해 한·양방 병행 치험 1례

손아현,최현민,고지윤,이동근,신현수,Son, Ah-hyun,Choi, Hyun-min,Go, Ji-yoon,Lee, Dong-keun,Shin, Hyeon-su 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

Objectives: The aim of this study is to describe the effects of traditional Korean medicine treatment on a patient with an intracerebral hemorrhage (ICH) at the left basal ganglia, thalamus, and posterior limb of the internal capsule. Methods: The patient was treated with acupuncture, moxibustion, Hyangsayukgunja-tang, and Samul-tang-gami. The effect of these treatments were evaluated using the manual muscle test (MMT), modified Barthel index (MBI), and National Institutes of Health Stroke Scale (NIHSS). Results: After the treatments, the patient's status improved, as shown by his MMT grade, which increased from 1/1 to 4/4. In addition, the patient's MBI score improved from 0 to 77, and his NIHSS score declined from 16 to 2. In addition, the patient's Levin tube and Foley catheter were removed. Conclusion: The results suggest that traditional Korean medicine may be effective in the treatment of patients with ICH.

영감오미강신하탕(苓甘五味薑辛夏湯)을 투여한 천식 환자 1례

손아현,고지윤,박아름,신현수,Son, Ah-hyun,Go, Ji-yoon,Park, A-reum,Shin, Hyeon-su 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.2

Objectives: This study evaluated the effects of traditional Korean medicine treatment on a patient with asthma. Methods: A patient was treated with acupuncture, herbal medicine, and cupping. The effect of treatment was evaluated via the quality of life questionnaire for adult Korean asthmatics (QLQAKA), the visual analog scale (VAS), and night awakening frequency. Results: After treatment, improvements were observed. The total QLQAKA score increased from 36 to 50. Conclusions: This study observed that traditional Korean medicine treatments are effective in caring for a patient with asthma.

당뇨병의 한의학적 치료에 대한 국내 실험연구 고찰 - 2013년 이후

손아현,고지윤,이동근,신현수,Son, Ah-hyun,Koh, Ji-yoon,Lee, Dong-keun,Shin, Hyeon-su 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1

Objective: This study reviewed experimental studies on the effects of Korean medical treatment for diabetes mellitus (DM). Method: We reviewed 24 studies about DM that had been published since 2013. We searched the Korean Institute of Oriental Medicine (KIOM) database with the keyword '당뇨', '消渴', 'Diabetes'. Results: 1. The studies used various Korean medicine treatments; 15 used single medicinal herbs, 6 used herbal complexes, and 2 used acupuncture. 2. The measurement parameters used in the studies included blood glucose, body weight, histochemical change, lipid parameters, and food/water intake. Anti-diabetic effects were demonstrated in most of the studies. 3. The experimental animals used were rats or mice. There were 15 type 1 diabetes models, 7 type 2 diabetes models, and one normal model. Among them, 13 cases of chemical diabetes induced by Streptozotosin (STZ, type 1 diabetes inducer) were the most common. Conclusion: Further articles on Korean medical treatment of DM should be studied.

급성기 뇌졸중의 혈전용해치료

손성일,조아현 대한의사협회 2009 대한의사협회지 Vol.52 No.4

For the patients suffering from acute ischemic infarct from abrupt occlusion of vessels, prompt reperfusion is necessary to save the ischemic penumbra, eventually leading to a good prognosis. Regarding this, intravenous (IV) recombinant tissue plasminogen activator (rt-PA) thrombolysis as a reperfusion therapy is the only approved method. The IV rt-PA therapy gives us a clinical benefit of 30% or more likelihood of favorable outcome compared to the placebo. However, there is about 6% symptomatic intracranial hemorrhagic risk. Therefore, prudent decision-making by selecting of indicated patients is the role of neurologists. Besides intravenous rt-PA thrombolysis, application of intra-arterial therapy or bridging concept of intra-arterial combined with IV rt-PA is promising. They showed better recanalization rate than that of IV therapy according to the controlled studies. Although the clinical evidence is lacking, they have been performed occasionally in well-facilitated institutions. The results of ongoing trials to support the clinical benefit of these active therapies are expected. In this article, we reviewed the major clinical trials for thrombolytic treatment of acute ischemic stroke and various trials which are under investigation for the extension of the time window for thrombolysis.

국내산 해조류의 중금속와 비소종 함량 및 건강 위험성 평가

김아현,강은혜,이수광,최소희,홍도희,이가정,윤민철,손광태,조미라 한국수산과학회 양식분과 2019 한국수산과학회 양식분과 학술대회 Vol.2019 No.5

Mesocosm을 이용한 습지에서의 인 거동 추정

손장원 ( Son Jang-won ),윤춘경 ( Yoon Chun Gyeong ),김형철 ( Kim Hyung Chul ),신아현 ( Shin Ah-hyun ),엄한용 ( Um Han Yong ) 한국농공학회 2007 한국농공학회 학술대회초록집 Vol.2007 No.-

This study was used the Mesocosm which presumes the movement of the nutrient substance (especially PO₄-P) of the wetland it was executed. After set up the Mesocosm inside the wetland and adding the PO₄-P, Observationed the movement of the PO₄-P follows at hour. It analyzed the factor which is the possibility of causing an effect in PO₄-P consistency of the wetland - Flora, Zooplankton, Phytoplankton, Absorbing rate of Algae, Settling rate, Release rate. Before adding The Consistency of the PO₄-P inside reed texture was average 3.44 mg/gDW, after adding it wad 2.91 mg/gDW with 36% reduced. The Algae is more sensitive than the plant in absorption of the nutrient. The Phytoplankton increased suddenly after PO₄-P adding. After adding the PO₄-P, almost there was not change of the Algae.

수면과다증을 동반한 심인성 요실금 환자 호전 1례

이동근,손아현,강미정,신현수,Lee, Dong-keun,Son, Ah-hyun,Kang, Mi-jung,Shin, Hyeon-su 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: This study evaluates the effects of traditional Korean medicine (including Guibi-tang) on a psychogenic urinary incontinence patient with hypersomnia disorder.Method: Herbal medicine, acupuncture, and moxibustion were carried out. The effect of the treatments was then evaluated via the Beck depression inventory (BDI), the Beck anxiety inventory (BAI), the symptom checklist-90-revised (SCL 90-R), the Epworth sleepiness scale (ESS), and the revised urinary incontinence scale (RUIS), as well as the number of urinations, incontinence levels, and sleeping times during the day.Results: After the treatments, both the urinary incontinence and hypersomnia symptoms showed improvement.Conclusion: This study suggests that traditional Korean medicine treatments are effective in caring for patients who suffer from psychogenic urinary incontinence with hypersomnia disorder.

LC-MS/MS를 이용한 넙치(Paralichthys olivaceus)시료의 톨트라주릴 및 톨트라주릴 설폰 분석

홍도희,김아현,이가정,윤민철,손광태,김명석,김나영,정승희,조미라 한국수산과학회 2019 한국수산과학회지 Vol.52 No.5

Several studies investigating the prevention and treatment of external parasites in farmed olive flounder Paralichthys olivaceus have found that the anticoccidial agent toltrazuril sulfone is an effective antiparasitic. Prior to undertaking a full-scale study, we developed analytical methods to detect the levels of toltrazuril and toltrazuril sulfone in farmed flounder samples using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS). This analysis showed that LC-MS/MS changed the mobile phase and collision energy of toltrazuril and toltrazuril sulfone. This was validated using established conditions. Sample pre-treatment for this process involved extraction with dichloromethane and purification by liquid–liquid extraction in formic acid, acetonitrile, and h-hexane, followed by determination of all compounds by LC-MS/MS. Separation was achieved within 10 min by gradient elution using a Capcell Pak C18 (3.0 μm, 100×2.0 mm) analytical column (Shiseido UG 120V) with a mixture of 0.1% (v/v) formic acid and acetonitrile. Multiple reaction monitoring was used for selective detection of toltrazuril and toltrazuril sulfone. This method yields satisfactory results for linearity, precision, and limits of quantification. Therefore, the method established in our study will serve as a basis for further research on parasite control by toltrazuril and toltrazuril sulfone.

뇌혈관질환 후 실어증의 한의학적 치료에 대한 국내 임상연구에 대한 고찰

고지윤,손아현,신현수 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.6

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords ‘Aphasia', ‘Oriental medicine', ‘Stroke' ‘Cerebral infarction', ‘Cerebral hemorrhage', and ‘Clinic', we searched domestic databases, including “NDSL (National Discovery for Science Leaders)", “Korean Traditional Knowledge Portal", “OASIS (Oriental Medicine Advanced Searching Integrated System)", and “RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject “Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in ‘Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

러시아 블라디보스토크산 패류 및 갑각류의 중금속 함량 및 위해도 평가

이수광,강은혜,김아현,최소희,홍도희,Ekaterina P. Karaulova,Mikhail V. Simokon,최우석,조미라,손광태,윤민철,유홍식 한국수산과학회 2019 한국수산과학회지 Vol.52 No.5

Exposure to heavy metals through the consumption of contaminated seafood poses a health risk to humans. In Korea, seafood imports are increasing with consumption, with the largest increase in imported seafood coming from Russia. Peter the Great Bay and the Razdolnaya River are both major fisheries and protected areas under the Northwest Pacific Action Plan located near Vladivostok, Russia. This study analyzed heavy metal [cadmium (Cd), lead (Pb), total mercury (tHg), and total (tAs), and inorganic (iAs) arsenic] concentrations in shellfish and crustaceans collected from these areas. Except for iAs, the major toxic heavy metal concentrations of the samples met the national standards (Cd, 0.024-0.982 and 0.003-0.379 mg/kg; Pb, 0.021-1.533 and 0.002 mg/kg; tHg, 0.006-0.015 and 0.036-0.097 mg/kg). The tAs concentrations of three samples exceeded the Russian standard (5 mg/kg, wet weight), whereas the iAs concentrations were extremely low (ND-0.033 mg/kg). Compared with the provisional tolerable weekly intake (PTWI) of the Ministry of Food and Drug Safety and Joint FAO/WHO Expert Committee on Food Additives, the percentages of PTWI of Cd, Pb, and tHg were 0.239%, 0.001-0.049%, and 0.013-0.302%, respectively. These findings reveal that there is no potential health risk by heavy metals through the consumption of Russian seafood obtained in the surveyed areas.