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성수아,고강지,조상경,조원용,김형규,이소영 대한의학회 2008 Journal of Korean medical science Vol.23 No.1
Neointimal hyperplasia causes vascular stenosis and subsequent thrombosis, which result in vascular access failure in patients undergoing hemodialysis. Interleukin-10 (IL-10) and tumour necrosis factor- (TNF- ) are involved in this inflammatory process. The aim of this study was to investigate the relationship between vascular access failure and various inflammatory markers including the genetic polymorphisms of IL-10 and TNF- . Seventy-five patients on hemodialysis with an arteriovenous fistula in place or an artificial graft (18 with vascular access failure and 82 without failure) and 98 healthy individuals were genotyped for IL-10 and TNF- single nucleotide polymorphisms. Clinical and laboratory data including serum IL-10 and TNF- levels were compared. Stimulated IL-10 levels, from in vitro incubation of blood with lipopolysaccharide, were also obtained and compared. Female gender, hypoproteinemia, and hypertriglyceridemia were associated with vascular access failure. The basal TNF- level was significantly higher in patients with access failure. The distribution of IL-10 and TNF- genotype did not differ among patients with or without access failure. This study could not demonstrate a relationship between genetic polymorphisms and vascular access failure. However, an altered immune response and inflammation might contribute to vascular access failure.
An Infrarenal Aortic Hypoplasia Presented with Claudication
성수아,황영환,이소영,조영권,권태원 대한의학회 2010 Journal of Korean medical science Vol.25 No.6
We describe a case of infrarenal aortic hypoplasia in a 52-yr-old woman who presented with claudication. Computed tomographic angiography revealed an abrupt absence of the infrarenal aorta, with collateral flow reconstituting the iliofemoral systems. After a polytetrafluoroethylene graft was interposed between the aortic stump and the iliac bifurcation, the patient’s claudication resolved.
급성 신우신염에서 급성 신부전이 동반된 환자들의 임상적 양상
성수아 ( Su Ah Sung ),강영선 ( Young Sun Kang ),이소영 ( So Young Lee ),김상욱 ( Sang Wook Kim ),이지은 ( Ji Eun Lee ),한금현 ( Kum Hyun Han ),서지아 ( Ji A Seo ),조원용 ( Won Yong Cho ),김형규 ( Hyoung Kyu Kim ) 대한내과학회 2003 대한내과학회지 Vol.64 No.2
목적: 급성 신우신염 환자에서 혈류량 부족, 패혈증, 약물 요법, 요로 폐쇄 등의 악화 요인 없이 급성 신부전이 동반되어 발생하는 임상 사례가 지속적으로 보고 되고 있어 저자들은 입원시 급성 신부전이 동반된 급성 신우신염 환자와 급성 신부전이 동반되지 않는 급성 신우신염 환자들의 임상상을 비교하여 급성 신우신염에서 급성 신부전과 관련된 인자를 파악하고자 본 연구를 시행했다. 방법: 1996년 1월부터 2000년 12월까지 만 5년 동안 고려대학교 안암병 Background: If acute renal failure develops in patients with acute pyelonephritis, it is most commonly due to hypovolemia, sepsis, drug therapy or urinary obstruction. But there have been reported many cases about patients of acute renal failure derived f