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유원정 ( Won Jeong Yoo ),박노현 ( Noh Hyun Park ),조현일 ( Hoen Il Jo ),채수진 ( Soo Jin Chae ),박인애 ( In Ae Park ),설혜실 ( Hye Sil Seol ),김재원 ( Jae Weon Kim ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.9
Neuroendocrine tumor is a very heterogenous group arising from the neuroendocrine cells. Especially, large cell neuroendocrine tumor of the ovary is a extremely rare aggressive neoplasm, characteristically arising in association with a surface epithelial tumor. This report describes a mixed type of large cell neuroendocrine carcinoma and adenocarcinoma of the ovary. A 63-year old woman presented with abdominal distension and discomfort underwent staging laparotomy under the impression of ovarian cancer. The operation revealed an small ovarian mass with invasion of multiple region in peritoneal cavity by the tumor. Immunohistochemical and ultrastructural analysis confirmed the neuroendocrine nature of the tumor. The adenocarcinoma in this case is mixture of mucinous and endometrioid type. A diagnosis of stage IIIc mixed large cell neuroendocrine tumor and adenocarcinoma of the ovary was rendered. She is subsequently being treated with Paclitaxel and Carboplatin combination chemotherapy.