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선경미,서혁진,권순영,이미희,권병주,김민성,구민아,박봉주,박종철 한국생체재료학회 2015 생체재료학회지 Vol.19 No.2
Background: Titanium is a well proven implantable material especially for osseointegratable implants by its biocompatibility and anti-corrosive surface properties. Surface characteristics of the implant play an important role for the evolution of bone tissue of the recipient site. Among the various surface modification methods, plasma treatment is one of the promising methods for enhance biocompatibility. We made microwave-induced argon plasma at atmospheric pressure to improve in titanium surface biocompatibility. Results: Various states of emission spectra from excited species-argon, nitrogen atoms and oxygen atoms were observed. The electron energy band structures are the unique characteristics of atoms and functional groups. Microwaveinduced argon plasma treatment changed the titanium surface to be very hydrophilic especially on the 5 s short treatment and 30 s, 90 s long treatment samples that detected by contact angle measurement. MC3T3-E1 attachment and proliferation assay significantly increased in 5 s at short treatment, 30 s, and 90 s at long treatment after 5 days incubation. Conclusions: Result indicated that microwave-induce argon plasma treatment would be an effective method to modify titanium surface for enhancing cell-material interactions.
최상훈,선경미,보쾅칸,손기태,양형철 대한치과재료학회 2022 대한치과재료학회지 Vol.49 No.4
Phosphatidylserine (PS) mimics the anti-inflammatory effect of apoptotic cells by binding to the PS receptor of macrophages. In this study, the effect of PS-modified polylactide-co-glycolide (PLGA) nanoparticles on macrophage polarization was investigated. PLGA nanoparticles (PLGAnPs) containing phosphatidylcholine (PC) and PS were prepared using the emulsification-solvent-evaporation (ESE) technique and classified as follows: 1) PC 100% (PCnP); 2) PS:PC = 50:50 (PSPCnP); and 3) PS100% (PSnP). PS-grafted PLGAnPs tended to inhibit LPS-induced morphological change into M1 macrophages and mRNA expressionof the M1 markers (TNF-α, IL-1β, IL-6, IL-12p40, CD86, and iNOS). In particular, the expressions of TNF-α, IL-6, and IL-12p40were significantly decreased in the PSPCnP group, as compared to those of the positive control and and PLGAnP groups(p<0.05). Therefore, the study results demonstrate the potential of PS-grafted PLGAnPs in attenuating inflammation and modulatingthe drug delivery system.
Biological Safety Evaluation of Polyketones as Biomaterials
Mi Hee Lee(이미희),Dae-Hyung Lee(이대형),Hyun-Sook Baek(백현숙),Byeong-Ju Kwon(권병주),Min-Ah Koo(구민아),Min Sung Kim(김민성),Gyeung Mi Seon(선경미),Jong-Chul Park(박종철) 한국고분자학회 2016 폴리머 Vol.40 No.2
생체재료는 의료기기로서 임상에 적용되기 위해서는 생물학적 안전성 평가에 의한 생체적합성 확보가 필수적이다. 이번 연구에서는 폴리케톤 고분자의 생체재료로서 사용 가능성을 평가하기 위해 생물학적 안전성 평가를 실시하였다. 폴리케톤 고분자의 용출물로 고분자의 생체적합성을 판단하는 생물학적 안전성 초기실험인 세포독성, 유전독성, 피부자극성, 감작성, 전신독성 시험을 실행하였다. 모든 시험에서 폴리케톤 고분자는 독성을 유발하지 않음을 확인할 수 있었으며, 이러한 결과는 폴리케톤 고분자가 생체재료로서 생물학적 안전성이 있으며 비분해성 고분자를 대체할 수 있을 것으로 판단된다. Biomaterials for clinical applications such as medical and implant devices require evaluation to determine their biocompatibility. This study aimed to evaluate the initial biological safety of polyketone (PK) polymers, which have potential use as biomaterials. It presents results from cytotoxicity and genotoxicity assays and tests determining the levels of skin irritation, sensitization, and acute systemic toxicity caused by PK. The PK polymers showed no cytotoxicity, genotoxicity, allergenicity, irritancy, and systemic toxicity. These results indicate that the PK polymers are potentially biological safe and could be used to replace non-degradable polymeric biomaterials.