Relapse After Cessation of Immunosuppressants in Seropositive Neuromyelitis Optica Spectrum Disorder With Long-Term Remission

석진명,박민수 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.4

Association Between Suggestive Symptom of Restless Legs Syndrome and COVID-19 Vaccination: A Pilot Study

석진명,나은진,김슬기,박종규,박은경,SONGPAMELA,양광익 대한수면연구학회 2022 Journal of sleep medicine Vol.19 No.1

Objectives: Various sensory symptoms have been recognized after COVID-19 vaccination. Here, we aimed to explore the association between the suggestive symptom of restless legs syndrome (RLSss) and COVID-19 vaccination using an online survey.Methods: We prospectively studied participants who were working in our hospital after at least the first dose of the ChAdOx1 or BNT162b2 mRNA vaccine. The participants were invited via smartphone messages and voluntarily filled out an online questionnaire that included adverse events after vaccination. We considered the participants as having RLSss if they reported that they had three or more symptoms in the restless legs syndrome (RLS) diagnostic criteria.Results: A total of 628 participants (506 female; mean age, 37.7±12.4 years) responded fully to our online survey. 588 participants (93.6%) received the first dose of the ChAdOx1 vaccine (BNT162b2 mRNA vaccine for 40 participants). A total of 44 out of the 628 participants (7.0%) reported that they had RLSss. Myalgia was more common in participants with RLSss than in those without RLSss (97.7% vs. 67.3%, p<0.001). Multivariate testing showed that age (odds ratio, 1.037 per 1 year increase; 95% CI, 1.004–1.071) and the presence of myalgia (odds ratio, 20.479; 95% CI, 4.266–368.206) were associated with the presence of RLSss.Conclusions: This pilot study explored RLSss after COVID-19 vaccination and the results suggested that RLS might be one of the causes of adverse symptoms after COVID-19 vaccination. Further studies are required to confirm the relationship between RLS and COVID-19 vaccination.

고등학교 <인공지능 수학> 교사 연수가 교사 개인의 교수효능감에 미치는 효과

류상주,석진명,강우혁,박재현 대한수학교육학회 2024 학교수학 Vol.26 No.1

본 연구에서는 2021년부터 진행된 고등학교 <인공지능 수학> 과목 교사 연수가 효능감에 미친 영향에 대한 효과와 인과적메커니즘을 분석하려 한다. 인과관계를 식별하는 방법으로 Pearl, J.가 창안한 인과추론 이론을 적용하였다. 선행연구를 참고하여처치변수와 결과변수에 영향을 미치는 변수들을 찾고 방향성 비순환 그래프를 작성하여 표본집단 전체에서 효과를 확인하였다. 또한, 세부 집단 간 효과의 차이를 분석함으로써 인과적 메커니즘을 유추하였다. 이를 바탕으로 <인공지능 수학> 과목 연수를위한 시사점을 제언하였다. This paper studies the effects and causal mechanism of teacher training in the high school <Artificial Intelligence Mathematics> course from 2021 on efficacy. We apply the theory of causal inference developed by Pearl, J. as a method for identifying causal mechanism. Based on previous studies, we search for variables that affect the treatment and outcome variables and draw a directed acyclic graph to confirm the effects among the whole sample. Moreover, we infer the causal mechanism by analyzing the differences in effects among the subgroups of the whole sample space. Based on this study, we suggest implications for teacher training in the <Artificial Intelligence Mathematics> course.

‘Sirim’ (Cold) Pain as a Common Symptom in Korean Patients with Clinically Suspected Small-Fiber Neuropathy

조은빈,석진명,민주홍,서범천,박기종,김병준 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.4

Background and Purpose Diagnosing small-fber neuropathy (SFN) is challenging because there is no gold-standard test and few diagnostic tests. This study investigated the clinical symptom profle and its associations with the results of quantitative sensory testing (QST) and the quantitative sudomotor axon refex test (QSART) as well as the quality of life (QOL) in patients with clinically suspected SFN. Methods Tis study involved 63 patients with clinically suspected length-dependent SFN. Assessments were performed using QST, QSART, SFN Symptoms Inventory Questionnaire, Neuropathic Pain Symptom Inventory, ‘Sirim’ frequency and ‘Sirim’ (cold) pain severity, and 36-item Short-Form Health Survey. Multiple logistic and linear regression analyses were performed to predict risk factors for QST or QSART abnormalities and QOL, respectively. Results ‘Sirim’ and ‘Sirim’ pain was the most-common (84%) and the most-severe complaint (mean score of 6.3 on a numerical rating scale ranging from 0 to 10) in patients with clinically suspected SFN. Te fndings of QST [cold detection threshold (CDT)] and QSART were abnormal in 71% (n=45/57) and 62% (n=39/56) of the patients, respectively. An abnormal CDT was correlated with more-severe stabbing pain (odds ratio=2.23, 95% CI=1.02– 4.87, p=0.045). Restless-leg symptoms (β=-7.077) and pressure-evoked pain (β=-5.034) were independent predictors of the physical aspects of QOL. Conclusions ‘Sirim’ pain, similar to cold pain, should be considered a major neuropathic pain in SFN. Among pain characteristics, stabbing pain of a spontaneous paroxysmal nature may be more pronounced in the setting of dysfunctional Aδ fbers with functional autonomic C fbers.

영재 사사과정에서 공학도구를 활용한 미적분 및 미분방정식 탐구 지도 사례

박재현,석진명,강우혁 한국과학영재교육학회 2024 과학영재교육 Vol.16 No.1

본 연구는 대학부설 과학영재교육원 사사과정 중학교 수학 영재들이 공학도구를 활용하여 미적분 및 미분방정식 기반 수학적 모델을 탐구하는 과정에 대한 1년간 지도 사례를 제시하고 영재교육에서의 시사점을 도출하는 데 목적이 있다. 본 연구에서 수행한 수업에서 공학도구는 식의 계산이나 그래프 등의 시각화를 위해 사용되었다. 공학도구를 사용함으로써 계산이나 그래프 작성 등에 할애하는 시간이 단축됨에 따라 모델에 대한 해석 및 논의 시간이 많이 확보되었다. 그 결과, 학생들은 미적분 및 미분방정식 모델을 이해하였으며 풍부한 논의 시간을 바탕으로 그래프를 활용하여 모델을 다양하게 해석하였다. 본 연구의 결과는 공학도구를 이용함으로써 중학교 영재 수준에서도 미적분 및 미분방정식 모델 탐구가 가능함을 보여준다. 또한, 공학도구를 이용하면 시각화는 수학을 관찰하고 발견하는 기회를 제공하고 학생 간의 상호작용을 위한 시간을 확보하여 풍부한 논의와 해석을 가능하게 하므로 영재 수업에서 공학도구를 활용할 필요성이 있다. The purpose of this study is to present a year-long instructional case study of middle school mathematically gifted students in Science Gifted Education Center using technological devices to explore mathematical models based oncalculus and differential equation, and to draw implications for gifted education. In the classes conducted in this study, technological devices were used to compute expressions and visualize graphs. The use of technological devices reduced the amount of time spent on calculations and graphing, allowing more time for interpretation and discussion of models. As a result, students understood the calculus and differential equation models and interpreted the models in various ways using graphs based on abundant discussion time. The results of this study show that it is possible to explore calculus and differential equation models at the middle school level by using technological devices. Furthermore, visualization with technological devices provides opportunities for observation and discovery of mathematics and allows for plentiful discussion and interpretation by securing time for interaction among students, so there is a need for more active use of technological devices in gifted classes.

Ischemic Stroke and Cancer: Stroke Severely Impacts Cancer Patients, While Cancer Increases the Number of Strokes

방오영,석진명,김선경,홍지만,김한영,이준,정필욱,박광열,김경문,정진상,이광호 대한신경과학회 2011 Journal of Clinical Neurology Vol.7 No.2

BackgroundzzCancer and ischemic stroke are two of the most common causes of death among the elderly, and associations between them have been reported. However, the main pathomechanisms of stroke in cancer patients are not well known, and can only be established based on accurate knowledge of the characteristics of cancer-related strokes. We review herein recent studies concerning the clinical, laboratory, and radiological features of patients with cancer-related stroke. Main ContentszzThis review covers the epidemiology, underlying mechanisms, and acute and preventive treatments for cancer-related stroke. First, the characteristics of stroke (clinical and radiological features) and systemic cancer (type and extent) in patients with cancer-specific stroke are discussed. Second, the role of laboratory tests in the early identification of patients with cancer-specific stroke is discussed. Specifically, serum D-dimer levels (as a marker of a hypercoagulable state) and embolic signals on transcranial Doppler (suggestive of embolic origin) may provide clues regarding changes in the levels of coagulopathy related to cancer and anticoagulation. Finally, strategies for stroke treatment in cancer patients are discussed, emphasizing the importance of preventive strategies (i.e., the use of anticoagulants) over acute revascularization therapy in cancer-related stroke. ConclusionzzRecent studies have revealed that the characteristics of cancer-related stroke are distinct from those of conventional stroke. Our understanding of the characteristics of cancer-related stroke is essential to the correct management of these patients. The studies presented in this review highlight the importance of a personalized approach in treating stroke patients with cancer.

스마트폰을 이용한 심호흡 기반 자율신경계 테스트

하상호,추창우,석진명,박종규,박상흠,Sangho Ha,Chang Woo Choo,Jin Myoung Seok,Jongkyu Park,Sang-Heum Park 한국정보처리학회 2023 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.12 No.7

심호흡을 통해서 심박수 변이를 측정하고, 이를 이용하여 자율신경계를 평가하는 것은 잘 알려진 방법으로 다양한 임상 분야에서 널리 이용되고 있다. 병원에서는 이를 위해서 고가의 장비가 설치되고 전문가에 의해서 운용되고 있다. 논문에서는 스마트폰을 이용하여 언제 어디서나 간편하게 심호흡을 통해서 자율신경계를 테스트할 수 있는 앱을 개발하고, 실험을 통해서 개발된 앱을 검증하였다. 실험은 지원자 8명에 대해서 순천향대학교 천안병원 신경과 임상실에서 진행되었다. 지원자에 대한 자율신경계 테스트를 다음 두 가지 방법으로 진행하였다. 먼저 병원에 설치된 근전도 검사기를 이용하였고, 다음에 동일한 조건에서 개발된 앱을 적용하였다. Pearson 방법을 이용하여 이 두 가지 방법의 실험 결과간에 상관 분석을 수행하였고, 분석 결과는 0.98의 매우 높은 상관관계를 보여준다. Measuring heart rate variability by deep breathing and using this to evaluate the autonomic nervous system is a well-known method widely used in various clinical fields. In hospitals, expensive equipment is installed and managed by experts for this purpose. This paper discusses an app we developed that can easily test the autonomic nervous system by deep breathing anytime, anywhere using a smartphone, and then reviews experiments performed to verify the results. The experiments were conducted in the clinical room of the Department of Neurology at Soonchunhyang University Cheonan Hospital on eight volunteers. We tested the autonomic nervous systems of the volunteers first with an electromyography device installed in the hospital and then with the app under identical conditions. We performed a correlation analysis on the results of these two methods using the Pearson method, and this yielded a very high correlation of 0.98.

Results of a Survey on Diagnostic Procedures and Treatment Choices for Neuromyelitis Optica Spectrum Disorder in Korea: Beyond the Context of Current Clinical Guidelines

이혜림,김수현,석진명,김병조,김호진,김병준 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.2

Background and Purpose Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating disease of the central nervous system (CNS). We investigated the medical behaviors of experts in Korea when they are diagnosing and treating NMOSD. Methods An anonymous questionnaire on the diagnosis and treatment of NMOSD was distributed to experts in CNS demyelinating diseases. Results Most respondents used the 2015 diagnostic criteria for NMOSD and applied a cerebrospinal fluid examination, magnetic resonance imaging (MRI) of the brain and spine, and anti-aquaporin-4 antibody testing to all suspected cases of NMOSD. All respondents prescribed steroid pulse therapy as an first-line therapy in the acute phase of NMOSD, and 67% prescribed azathioprine for maintenance therapy in NMOSD. However, details regarding monitoring, the tapering period of oral steroids, second-line therapy use in refractory cases, management during pregnancy, and schedule of follow-up MRI differed according to the circumstances of individual patients. We analyzed the differences in response rates between two groups of respondents according to the annual number of NMOSD patients that they treated. The group that had been treating ≥10 NMOSD patients annually preferred rituximab more often as the second-line therapy (p=0.011) and had more experience with rituximab treatment (p=0.015) compared with the group that had been treating <10 NMOSD patients. Conclusions This study has revealed that NMOSD experts in Korea principally follow the available treatment guidelines. However, the differences in specific clinical practices applied to uncertain cases that have been revealed will need to be investigated further in order to formulate suitable recommendations.

자기공명영상에서 병터가 관찰되지 않는 말이집희소돌기아교세포당단백질 자가항체 관련 척수염 증례

박종규,김형기,석진명 대한신경과학회 2022 대한신경과학회지 Vol.40 No.1

Unusual Demyelinating Disease of the Central Nervous System Involving Bilateral Corticospinal Tracts Following COVID-19 Infection: A Case Report

주현진,김영훈,석진명,김병준 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.5