Complete Remission in a Patient with Human Herpes Virus-8 Negative Multicentric Castleman Disease Using CHOP Chemotherapy

서희연,신봉경,김석진,김병수,김의배,김지원 대한암학회 2009 Cancer Research and Treatment Vol.41 No.2

Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months’ duration. The complete blood count revealed an elevated leukocyte count (15.1x103/uL) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymphadenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacterium infection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient’s fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24 months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.

핑크색 파일이 알려준 진실

서희연 샘터사 2018 월간 샘터 Vol.581 No.-

진행성 위암에 대한 Oxaliplatin, 5FU, LV 복합 화학요법의 치료 효과와 독성

서희연,설혜령,최종권,성화정,박경화,최인근,김석진,최철원,김병수,신상원,김열홍,김준석 대한내과학회 2004 대한내과학회 추계학술대회 Vol.2004 No.1

성인 비만과 비교를 통한 소아 비만의 특성 연구 - 천안 지역 중심으로

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.2

Objectives The recent prevalence rate of obesity in children is increasing, but so far the majority of ongoing research is focused on obesity in adults. Even comparison studies between obesity in adults and in children are insufficient at this stage. Thus, our research will investigate the characteristics of obesity in children based on the comparison with adults. Methods The blood levels including glucose, cholesterol, AST, ALT of obese children and obese adults were compared and analyzed. Results From comparison studies, the levels of glucose, cholesterol, ALT in adults were higher than in children. In order to take account the age differences, only the rate of abnormal levels based on the reference range were compared. As a result, the abnormal rate in blood cholesterol level was higher in children. Conclusions Childhood obesity may develop complications at early age and has high potential risk to result in adult obesity as well. Therefore, child obesity needs to be treated with more caution and careful attention.

4차 산업혁명 시대의 중국미술시장 분석과 대응전략

서희연 한국문화예술경영학회 2017 문화예술경영학연구 Vol.10 No.2

중국 미술시장은 최근 세계 경매시장에서 주도적 위치를 확보하였다. 이 논문에서는 중국미술의 돌풍 요인에 대 해 소비자 취향 변화 및 독특한 중국식 사회주의적 성격을 바탕으로 설명하였다. 또한 중국의 경제성장에 따른 중국 미술시장의 과도한 열기에 대해 최근 옥션 데이터를 분석하여 살펴보았다. 중국 미술가들의 경매 시장 판매액 순위 는 서구권 작가들에 비해 가파르게 상승하였으나 최근 들어 빠링 호우 세대들이 중국 경매시장에 큰손으로 등극하면 서 시장의 흐름이 뒤바뀌고 있다. 한편 4차 산업혁명의 시대를 맞아 전 세계적으로 미술시장 주요 구성원들의 위치 도 바뀌고 있는 추세이다. 이처럼 시대가 급변하고 업계의 판도가 달라지는 현 시점에서 중국 미술시장의 분석과 미 술계 전체의 주체 분석을 통해 중국 미술시장에 대응하기 위한 전략을 논의하였다. The Chinese art market has recently secured a dominant position in the global auction market. In this paper, the dramatic growth of the Chinese art market was explained based on consumer tastes and unique Chinese style of socialism. In doing so, the overheated Chinese art market led by China's economic growth was analyzed and examined. Market prices of artworks of Chinese artists have skyrocketed over those of the Western artists, but the trend has been shifting in recent years as the Balinghou (Post-'80 generation) becomes a major player in the Chinese auction market. Furthermore, the major players in the Chinese art market are changing in the wake of the fourth industrial revolution. This paper discussed the Chinese art market, focusing especially on the strategies to overcome these environmental changes.

식이 자기 효능감: 한국어판 Weight Efficacy Life-Style 설문지 개발 — 횡문화적 번역 및 안면 타당도 검증

서희연,옥지명,김서영,임영우,박영배 한방비만학회 2019 한방비만학회지 Vol.19 No.1

Objectives: Eating self-efficacy is an important predictor of successful weight control behaviors during obesity treatment. The Weight Efficacy Life-Style Questionnaire (WEL) is an internationally used measure of eating self-efficacy. The objective of this study was to develop the Korean version of WEL (K-WEL) and verify face validity. Methods: According to previously published guidelines, the cross-cultural translation was conducted through organizing the expert committee, translation, back-translation, synthesis, grammar review, and final synthesis. Following the translation of the WEL into Korean, face validity was performed for 35 subjects. Results: After all the versions of the questionnaire were examined, the translated WEL questionnaires were finally synthesized and licensed by the developer in writing. Regarding the translated WEL questionnaires, seven out of 35 subjects (20%) offered ideas about ambiguous expressions in them. All four points indicated in the face validity verification were additionally modified for greater clarity and understanding. Conclusions: We developed the Korean version of WEL and completed face validity. In future research, it would be necessary to provide further study on the reliability and validity of the Korean version of WEL.

이중탕(理中湯)이 Mite Antigen으로 유발된 NC/Nga 생쥐의 아토피 피부염에 미치는 영향

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to investigate the effects of Yijungtang(YJT) on atopic dermatitis in an in-vitro and in-vivo experiment using a RBL-2H3 mast cells and a NC/Nga atopic dermatitis mouse. Methods: In-vitro experiment, IL-4, IL-13 mRNA expression were evaluated by a real-time PCR, IL-4, IL-13 production by ELISA and transcription factor as GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-kB by western blotting. In-vivo experiment, clinical skin score we evaluated by, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mouse, cytokine level, total number of cell, Immunohistochemical staining and Histological features of auxiliary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue in NC/Nga mouse. Results: YJT decreased IL-4, IL-13 mRNA expression, IL-4, IL-13 production and prominently decreased the expression of mast cell specific transcription factors including GATA-2, NF-AT2, c-Fos and NF-kB. YJT oral administration reduced the levels of skin severity scores. It also decreased the level of inflammatory cytokines such as IL-5, IL-13, histamine and IgE in the serum. It elevated IFN-gamma level in the spleenocyte culture supernatant but decreased. $CD3e^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $CD11b^+Gr-1^+$, $CCR3^+$ in the PBMCs, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $B220^+CD23^+$ in the ALN, $CD4^+$, $CD3e^+CD69^+$ in the ALN and $CD4^+$, $CD11b^+Gr-1^+$ in the dorsal skin. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by YJT oral administration. Conclusions: The anti-allergic activities of YJT may be mediated by down-regulation of Th2 cytokines, such as IL-4 and IL-13, through the regulation GATA-2, NF-AT2 and NF-kB transcription factors in mast cells. YJT would be regulate molecular mediators and immune cells which are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.

명 말 기녀 서화가 마수진의 난죽화에 관한 연구

서희연 한국서예학회 2022 서예학연구 Vol.40 No.-

Ma Shou-zhen, who was active mainly with Jin Hoe-ha of late ming China Nan-jing, achieved outstanding achievements in orchid painting. This study examines the artistic interaction between Ma Shou-zhen and her lover, Wang Zhi-deung, a supporter of the wu-school literary circle, the role of Ma Shou-zhen in disseminating the art theory of the wu-school flower bed, and the symbolic meaning of the orchid in the Ma Shou-zhen orchid bamboo painting. I looked into Through this, although Ma Shou-zhen had a low status as a prostitute from Cheong-ru, she was a calligrapher whose talent was recognized not only as an wu shool writer but also abroad. I knew he was an artist. In addition, it could be seen that there were people such as Wang Zhi-deung in the background of her success. Wang Zhi-deung and others communicated with her Ma Shou-zhen and informed them of his calligraphy and painting theory, and Ma Shou-zhen , who was influenced by this, created a private orchid bamboo painting of wu-school style from her orchid bamboo paintings. Through Ma Shou-zhen 's orchid bamboo paintings, Wang Zhi-deung was able to spread the theory of Opa calligraphy and painting to future generations, and Ma Shou-zhen was also able to build wealth and fame as a popular calligrapher at the end of the Ming Dynasty. Therefore, Ma Shou-zhen 's orchid bamboo paintings played an important role in disseminating wu-schhol's calligraphy and painting theory, and it was found that the popularity of Ma Shou-zhen 's orchid paintings, a calligrapher from a prostitute, in the history of Chinese painting, was a result of reflecting wu-school's artistic status. 명 말시기 남경의 진회하를 중심으로 활동했던 마수진은 난죽화에서 뛰어난 성취를 이루었다. 본 연구는 마수진과 그녀의 연인이자 오파 문단의 지지자 왕치등 사이의 예술적 상호작용에 대해 고찰하고, 오파 화단의 예술론 전파에 마수진이 했던 역할과 마수진 난죽화가 속 난죽이 가지는 상징적 의미에 대해 고찰해 보았다. 이를 통해 마수진은 비록 청루 출신의 기녀인 낮은 신분이었지만, 오파 문인뿐만 아니라 해외에서까지도 그 재능을 인정받은 서화가였으며 이러한 기녀 서화가가 아닌 한 사람의 독자적인 서화가로서 인정받은 성공한 예술가였음을 알 수 있었다. 또한, 이러한 성공의 배경에는 왕치등이라는 인물이 있었음을 알 수 있었다. 왕치등은 마수진과 교유하며 자신의 서화론을 알려주었으며 이에 영향을 받은 마수진은 난죽화에서 오파풍의 사의적인 난죽화를 창작했다. 왕치등은 마수진의 난죽화를 통해 오파 서화 이론을 후대에까지 널리 알릴 수 있었으며 마수진 역시 명 말 인기 있는 서화가로서 부와 명성을 쌓을 수 있었다. 따라서 마수진의 난죽화는 오파의 서화 이론 보급에 중요한 역할을 했으며 중국 회화사에서 기녀 출신 서화가 마수진의 난죽화 작품의 인기는 결과적으로 오파의 예술적 위상을 반영한 결과물임을 알 수 있었다.

추억을 만드는 아빠표 음식

서희연 샘터사 2020 월간 샘터 Vol.601 No.-

치과용 복합레진의 중합 전 slumping resistance와 점탄성

서희연,이인복 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.3

본 연구의 목적은 복합례진의 slumping resistance를 측정할 수 있는 방법을 개발하고, 그 유용성을 평가하기 위해 rheometer를 이용해 측정된 복합레진의 여러 유변학적 성질과 slumping resistance의 상호 관련성을 밝히고자 하였다. 상용되는 hybrid composites (Z100, Z250, DenFil, Tetric Ceram, ClearFil)와 nanofll composite (Z350)를 2 ㎜두께의 디스크 모양의 시편으로 만들었다. 사각형의 단면을 가진 알루미늄 형판으로 레진 디스크를 눌러 표준화된 자국을 남겼다. 이것을 즉시 광중합하거나 (no-slump) 25℃에서 3 분간 방치 한 후에 광중합 하였다 (slumped).흰 경석고로 광중합된 레진을 복제한 후 laser 3-D profilometer로 표면의 단면 영상을 얻었다. Slumping 전 후 홈의 깊이의 비를 구해 slumping resistance index (SRI)라 정의하였다. 각 복합레진의 중합 전 전단 점탄성을 측정하기 위해 회전형 rheometer를 이용하여 동적회전전단실험과 squeeze test를 시행하였다. 더불어 flow test를 시행하였다. 동적회전전단실험 및 압착실험의 결과와 8RI와 상호관련성을 조사하기 위해 상관분석을 하였다. 여섯 가지의 재료의 SRI 값에는 차이가 있었다 (Z100 < DenFil < Z250 < ClearFil < Tetric Ceram < Z350). SRI는 전단 점성(손실)계수 G" 와 가장 큰 양의 상관관계를 보였으며 Tan δ는 SRI와 상관관계가 없었다. SRI는 수직 가압에 대한 저항 보다 전단흐름에 대한 저항과 관련성이 높았다. 본 연구에서 도입된 imprint method와 SRI는 복합레진이 slumping 되는 경향을 정량화하였으며 복합레진 조작성의 평가방법으로 사용할 수 있었다. The aim of this study was to develop a method for measuring the slumping resistance of resin composites and to relate it to the rheological characteristics. Five commercial hybrid composites (Z100, Z250, DenFil, Tetric Ceram, ClearFil) and a nanofill composite (Z350) were used to make disc-shaped specimens of 2 ㎜ thickness. An aluminum mold with square shaped cutting surface was pressed onto the composite discs to make standardized imprints. The imprints were light-cured either immediately (non-slumped) or after waiting for 3 minutes at 25℃ (slumped). White stone replicas were made and then scanned for topography using a laser 3-D profilometer. Slumping resistance index (SRI) was defined as the ratio of the groove depth of the slumped specimen to that of the non-slumped specimen. The pre-cure viscoelasticity of each composite was evaluated by an oscillatory shear test and normal stress was measured by a squeeze test using a rheometer. Flow test was also performed using a flow tester. Correlation analysis was performed to investigate the relationship between the viscoelastic properties and the SRI. SRI varied between the six materials (Z100 < DenFil < Z250 < ClearFil < Tetric Ceram < Z350). The SRI was strongly correlated with the viscous (loss) shear modulus G ' but not with the loss tangent. Also, slumping resistance was more closely related to the resistance to shear flow than to the normal stress. Slumping tendency could be quantified using the imprint method and SRI. The index may be applicable to evaluate the clinical handling characteristics of composites.