理中湯이 IgE가 과잉생성되고 피부염이 유발된 NC/Nga생쥐에서 IFN-γ 반응에 의한 Th2 세포분화 억제에 미치는 영향

서희연,김윤희,한재경 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.1

Objectives The purpose of this study is to investigate the effect of Li Zhong Tang(LZH-T) on atopic dermatitis by using NC/Nga atopic dermatitis mouse. Methods First, in vitro, we isolated B cells from NC/Nga mouse which induced atopic dermatitis-like skin for 18 weeks. We analyzed FACS by intracellular staining of IFN-γ, GATA-3+ and also analyzed cytokines by using real-time PCR. Secondly, in vivo , after administration of LZH-T to the 12 weeks old mouse with atopic dermatitis. We analyzed serum IgE, IFN-γ level and observed the changes of activated cell. Results In vitro, LZH-T decreased the levels of CD4+/IFN-γ+ and increased the levels of CD4+/GATA3+. In vivo, serum IgE levels were decreased and IFN-γ levels were increased in LZH-T group compared to the control group. In PBMCs, the percentage of activated cell - granulocytes, CD3+, CD3+CD4+, B220+CD23+, and CCR3+ were decreased and CD19+, CD3+CD8+ were increased in LZH-T group compared to the control group. Conclusions This study demonstrates immunological activity of GPJST on atopic dermatitis-like model mice.

이중탕(理中湯)이 Mite Antigen으로 유발된 NC/Nga 생쥐의 아토피 피부염에 미치는 영향

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: The purpose of this study is to investigate the effects of Yijungtang(YJT) on atopic dermatitis in an in-vitro and in-vivo experiment using a RBL-2H3 mast cells and a NC/Nga atopic dermatitis mouse. Methods: In-vitro experiment, IL-4, IL-13 mRNA expression were evaluated by a real-time PCR, IL-4, IL-13 production by ELISA and transcription factor as GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-kB by western blotting. In-vivo experiment, clinical skin score we evaluated by, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mouse, cytokine level, total number of cell, Immunohistochemical staining and Histological features of auxiliary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue in NC/Nga mouse. Results: YJT decreased IL-4, IL-13 mRNA expression, IL-4, IL-13 production and prominently decreased the expression of mast cell specific transcription factors including GATA-2, NF-AT2, c-Fos and NF-kB. YJT oral administration reduced the levels of skin severity scores. It also decreased the level of inflammatory cytokines such as IL-5, IL-13, histamine and IgE in the serum. It elevated IFN-gamma level in the spleenocyte culture supernatant but decreased. $CD3e^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $CD11b^+Gr-1^+$, $CCR3^+$ in the PBMCs, $CD4^+$, $CD8^+$, $CD3e^+CD69^+$, $B220^+CD23^+$ in the ALN, $CD4^+$, $CD3e^+CD69^+$ in the ALN and $CD4^+$, $CD11b^+Gr-1^+$ in the dorsal skin. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by YJT oral administration. Conclusions: The anti-allergic activities of YJT may be mediated by down-regulation of Th2 cytokines, such as IL-4 and IL-13, through the regulation GATA-2, NF-AT2 and NF-kB transcription factors in mast cells. YJT would be regulate molecular mediators and immune cells which are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.

차 한 잔의 미학: 문징명의 다화에 담긴 유·도 사상의 융합

서희연 충남대학교 유학연구소 2024 유학연구 Vol.69 No.-

본 연구는 명대 문인화가 문징명(文徵明)의 다화(茶畵) 작품에 담긴 유가(儒家)와도가(道家) 사상의 융합적 미학(美學)을 분석하고, 차(茶) 문화를 통해 문인들이 철학적 사유와 도덕적 성숙을 추구한 방식을 규명하고자 하였다. 문징명은 차 마시는행위를 단순한 음다(飮茶)를 넘어서, 유가의 천인합일(天人合一)과 도가의 정경합일(情景合一)을 구현한 작품들에서 인간과 자연의 조화를 시각적으로 표현하였다. 본 논문에서는 〈혜산다회도(惠山茶會圖)〉,〈교림자명도(喬林煮茗圖)〉, 〈품다도(品 茶圖)〉,〈진상재도(真賞齋圖)〉 등의 주요 다화작품을 중심으로 유가적 질서와 도가적 자유가 어떻게 예술적으로 융합되었는지 탐구하였다. 연구 결과, 문징명의 다화는 자연 속에서 茶를 마시는 문인들의 내면적 성숙과 이상적인 삶을 반영하며, 차문화를 중요한 철학적 매개체로 승화시켰음을 밝혔다. 차와 자연의 결합을 통해 동양 미학에서 인간과 자연의 조화와 상호작용을 강조한 점은 문징명 예술의 중요한특징으로 나타났다. 이러한 융합적 미학은 단순한 시각적 표현을 넘어서, 차를 매개로 한 문인들의 철학적 성찰과 도덕적 가치관이 반영된 결과로 해석된다. 이번연구는 문징명의 작품이 동양 철학의 핵심 사상을 시각적으로 구현한 중요한 예술적 표현임을 재조명하며, 차 문화와 철학적 사유의 융합이 문인들 사이에서 이상적인 삶을 실현하는 중요한 수단이었음을 밝혔다. 이는 차가 단순한 음료를 넘어서, 인간의 도덕적 성장과 자연의 조화로운 관계를 탐구하는 데 필수적인 요소임을 의미한다. 나아가, 문징명의 다화 작품이 동양 미학에서 茶 문화의 철학적 가치를 더욱 심화시키는 데 기여했음을 제시한다. This study analyzes the integration of Confucianism and Daoism in the tea paintings of the Ming Dynasty literati painter, Wen Zhengming, focusing on how he expressed philosophical reflections and moral maturity through tea culture. Wen Zhengming's works transcend the simple act of drinking tea, visually portraying the harmony between humanity and nature by integrating Confucian Unity of Heaven and Man (Tianren Heyi, 天人合一) and Daoist unity of Emotion and Scene (Qingjing Heyi, 情景合一). Focusing on his representative works, such as "Huishan Tea Gathering (惠山茶會圖)," "Jiaolin Brewing Tea (喬林煮茗圖)," "Tea Tasting (品茶圖)," and "Zhenshang Studio (真賞齋圖)," the study explores how the Confucian order and Daoist freedom were aesthetically fused. The research reveals that Wen’s tea paintings reflect the ideal life of literati, pursuing inner maturity and peace, while elevating tea culture as a key philosophical medium. His emphasis on the interaction between tea and nature highlights the distinctive feature of Eastern aesthetics in representing the unity between humans and nature. This study contributes to a reappraisal of Wen Zhengming’s works as significant artistic expressions that embody the core principles of Eastern philosophy, demonstrating how tea culture and philosophical reflection served as vital mediums for literati to achieve their ideal way of life.

서창희, 『내 인생, 여기서 끝나지 않는다』

서희연 기독교대한성결교회 활천사 2018 활천 Vol.781 No.12

무위의 정원: 졸정원에 담긴 도가 철학에 관한 연구

서희연 충남대학교 유학연구소 2025 유학연구 Vol.70 No.-

본 연구는 중국 강남 소주(蘇州)에 위치한 졸정원(拙政園)이 도가(道家) 철학의핵심 개념인 ‘무위(無爲)’와 ‘천인합일(天人合一)’을 어떻게 공간적으로 구현하였는지를 분석한다. 졸정원은 명대 왕헌신(王獻臣, 1469~?)이 설계한 사가(私家) 원림으로, 단순한 조경 공간이 아니라 자연과 인간이 조화를 이루며 철학적 사유가 실현되는 장소로서 기능하였다. 본 연구는 졸정원의 공간 설계가 도가 철학의 이념을어떻게 반영하는지를 심층적으로 탐구하며, 특히 자연의 흐름을 따르는 비대칭적배치, 인위적 개입을 최소화하는 ‘무위’의 원리, 건축물과 조경이 조화롭게 연결된구조를 중심으로 논의를 전개한다. 졸정원의 설계에서 나타나는 공간적 특징은 단순한 미적 요소를 넘어, 공간 자체가 도가 철학을 실천하는 방식으로 작용한다. 주요 건축물과 경관 요소들은 정형화된 축선 없이 자유롭게 배치되었으며, 이는 도가에서 강조하는 ‘자연의 이치에 순응하는 공간 형성’을 실현한 사례라 할 수 있다. 또한, 졸정원의 물길과 조경 설계는 단순한 경관적 요소를 넘어, 인간과 자연이 상호작용하며 하나의 유기적 관계를 형성하는 구조를 형성하고 있다. 특히 본 연구는 졸정원의 ‘이수(理水)’ 개념이 도가 철학과 어떻게 연결되는지를고찰하며, 유가(儒家) 철학에서 강조하는 ‘치수(治水)’ 개념과 비교하여 졸정원이도가 철학을 기반으로 한 조경 설계를 실현하였음을 논증한다. 또한, 졸정원이 단순한 자연 감상 공간이 아니라 당대 문인들의 철학적 이상과 사유가 담긴 공간으로작용했다는 점을 강조하며, 졸정원이 지닌 문화적, 철학적 가치를 재조명한다. 본 연구는 졸정원이 도가 철학을 실천한 중요한 사례로서, 자연과 인간의 조화로운 관계를 공간적으로 형상화한 예술적 공간임을 입증하며, 이를 바탕으로 현대 조경 설계와 환경 디자인에서 도가 철학이 적용될 가능성에 대한 새로운 시각을 제공하고자 한다. This study analyzes how the Humble Administrator’s Garden (拙政園), located in Suzhou, Jiangnan, China, spatially embodies the core concepts of Wu Wei (無爲) and Tian Ren He Yi (天人合一) in Daoist philosophy. Designed by Wang Xianchen (王獻臣, 1469~?) during the Ming Dynasty, the garden functions not merely as a landscaped space but as a site where nature and humanity achieve harmony and where philosophical contemplation is realized. This research explores how the garden’s design principles reflect Daoist thought, focusing on its asymmetrical layout following the natural flow, the principle of Wu Wei that minimizes artificial intervention, and the harmonious integration of architecture and landscape. The spatial characteristics of the Humble Administrator’s Garden go beyond aesthetics, functioning as an architectural realization of Daoist philosophy. The major buildings and scenic elements are arranged freely, without a rigid axial alignment, embodying the formation of space in accordance with natural principles as emphasized in Daoism. Furthermore, the garden’s waterways and landscape features are not merely ornamental; rather, they establish a dynamic interaction between humans and nature, forming an integrated, organic relationship. In particular, this study examines the concept of Li Shui (理水)—the management of water—and its connection to Daoist philosophy. By comparing this concept with the Confucian principle of Zhi Shui (治水)—the regulation of water for societal stability—this study argues that the Humble Administrator’s Garden represents a unique Daoist approach to landscape architecture. Additionally, this study highlights the garden’s role as a philosophical space that encapsulates the ideals and intellectual pursuits of the literati of its time, positioning it as a cultural and philosophical heritage. As a significant example of the practical application of Daoist philosophy, this study demonstrates how the Humble Administrator’s Garden materializes the harmonious relationship between nature and humanity. Furthermore, this research provides new insights into the potential integration of Daoist principles into contemporary landscape design and environmental planning, emphasizing the continued relevance of Daoist aesthetics and philosophy in modern spatial practices.

명 말 기녀 서화가 마수진의 난죽화에 관한 연구

서희연 한국서예학회 2022 서예학연구 Vol.40 No.-

Ma Shou-zhen, who was active mainly with Jin Hoe-ha of late ming China Nan-jing, achieved outstanding achievements in orchid painting. This study examines the artistic interaction between Ma Shou-zhen and her lover, Wang Zhi-deung, a supporter of the wu-school literary circle, the role of Ma Shou-zhen in disseminating the art theory of the wu-school flower bed, and the symbolic meaning of the orchid in the Ma Shou-zhen orchid bamboo painting. I looked into Through this, although Ma Shou-zhen had a low status as a prostitute from Cheong-ru, she was a calligrapher whose talent was recognized not only as an wu shool writer but also abroad. I knew he was an artist. In addition, it could be seen that there were people such as Wang Zhi-deung in the background of her success. Wang Zhi-deung and others communicated with her Ma Shou-zhen and informed them of his calligraphy and painting theory, and Ma Shou-zhen , who was influenced by this, created a private orchid bamboo painting of wu-school style from her orchid bamboo paintings. Through Ma Shou-zhen 's orchid bamboo paintings, Wang Zhi-deung was able to spread the theory of Opa calligraphy and painting to future generations, and Ma Shou-zhen was also able to build wealth and fame as a popular calligrapher at the end of the Ming Dynasty. Therefore, Ma Shou-zhen 's orchid bamboo paintings played an important role in disseminating wu-schhol's calligraphy and painting theory, and it was found that the popularity of Ma Shou-zhen 's orchid paintings, a calligrapher from a prostitute, in the history of Chinese painting, was a result of reflecting wu-school's artistic status. 명 말시기 남경의 진회하를 중심으로 활동했던 마수진은 난죽화에서 뛰어난 성취를 이루었다. 본 연구는 마수진과 그녀의 연인이자 오파 문단의 지지자 왕치등 사이의 예술적 상호작용에 대해 고찰하고, 오파 화단의 예술론 전파에 마수진이 했던 역할과 마수진 난죽화가 속 난죽이 가지는 상징적 의미에 대해 고찰해 보았다. 이를 통해 마수진은 비록 청루 출신의 기녀인 낮은 신분이었지만, 오파 문인뿐만 아니라 해외에서까지도 그 재능을 인정받은 서화가였으며 이러한 기녀 서화가가 아닌 한 사람의 독자적인 서화가로서 인정받은 성공한 예술가였음을 알 수 있었다. 또한, 이러한 성공의 배경에는 왕치등이라는 인물이 있었음을 알 수 있었다. 왕치등은 마수진과 교유하며 자신의 서화론을 알려주었으며 이에 영향을 받은 마수진은 난죽화에서 오파풍의 사의적인 난죽화를 창작했다. 왕치등은 마수진의 난죽화를 통해 오파 서화 이론을 후대에까지 널리 알릴 수 있었으며 마수진 역시 명 말 인기 있는 서화가로서 부와 명성을 쌓을 수 있었다. 따라서 마수진의 난죽화는 오파의 서화 이론 보급에 중요한 역할을 했으며 중국 회화사에서 기녀 출신 서화가 마수진의 난죽화 작품의 인기는 결과적으로 오파의 예술적 위상을 반영한 결과물임을 알 수 있었다.

이중탕(理中湯)이 IgE가 과잉생성되고 피부염이 유발된 NC/Nga생쥐에서 $IFN-{\gamma}$ 반응에 의한 Th2 세포분화 억제에 미치는 영향

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.1

Objectives The purpose of this study is to investigate the effect of Li Zhong Tang(LZH-T) on atopic dermatitis by using NC/Nga atopic dermatitis mouse. Methods First, in vitro, we isolated B cells from NC/Nga mouse which induced atopic dermatitis-like skin for 18 weeks. We analyzed FACS by intracellular staining of $IFN-{\gamma}$, GATA-3+ and also analyzed cytokines by using real-time PCR. Secondly, in vivo, after administration of LZH-T to the 12 weeks old mouse with atopic dermatitis. We analyzed serum IgE, $IFN-{\gamma}$ level and observed the changes of activated cell. Results In vitro, LZH-T decreased the levels of CD4+/$IFN-{\gamma}$ and increased the levels of CD4+/GATA3+. In vivo, serum IgE levels were decreased and $IFN-{\gamma}$ levels were increased in LZH-T group compared to the control group. In PBMCs, the percentage of activated cell - granulocytes, CD3+, CD3+CD4+, B220+CD23+, and CCR3+ were decreased and CD19+, CD3+CD8+ were increased in LZH-T group compared to the control group. Conclusions This study demonstrates immunological activity of GPJST on atopic dermatitis-like model mice.

비만과 골성숙도의 상관성에 대한 연구

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : As obese children have been increased, the interest in the impact of obesity on growth also have been increased. This study is to examine relations between obesity and skeletal maturity by analyzing body compositions and bone age. Methods : Subjects were composed of 233 children from 6 years to 17 years of age, without any other diseases related to growth, who visited the department of pediatrics, OO oriental medicine hospital and measured their body composition (body mass index, body fat ratio, fitness score) and bone age. Results : 1. As body mass index was increased, the skeletal maturity significantly was also increased. 2. As the mean of bone maturity was increased, the BMI was increased from the underweight type to the normal type to the overweight type; the bone maturity was increased as the fat ratio was increased from the normal type to the obese type to the excessively obese type; and the bone maturity was higher in the weak, obese type than the normal type when classified according to the Fitness Score. 3. The bone maturity of the overweight group in the BMI classification and excessively obese group in the fat ratio classification significantly were increased. 4. Skeletal maturity significantly was increased in children who developed secondary sexual character. 5. The significance of obesity causing increase of the skeletal maturity was higher in boys than in girls. 6. Only in the case of children without development of secondary sexual character, obesity caused an significant increases in the skeletal maturity. Conclusions : Obesity could cause the increase of skeletal maturity, and the obesity could affect more to the boys than girls and more to the children than teenagers.

성인 비만과 비교를 통한 소아 비만의 특성 연구 - 천안 지역 중심으로

서희연,한재경,김윤희,Seo, Hui-Yeon,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.2

Objectives The recent prevalence rate of obesity in children is increasing, but so far the majority of ongoing research is focused on obesity in adults. Even comparison studies between obesity in adults and in children are insufficient at this stage. Thus, our research will investigate the characteristics of obesity in children based on the comparison with adults. Methods The blood levels including glucose, cholesterol, AST, ALT of obese children and obese adults were compared and analyzed. Results From comparison studies, the levels of glucose, cholesterol, ALT in adults were higher than in children. In order to take account the age differences, only the rate of abnormal levels based on the reference range were compared. As a result, the abnormal rate in blood cholesterol level was higher in children. Conclusions Childhood obesity may develop complications at early age and has high potential risk to result in adult obesity as well. Therefore, child obesity needs to be treated with more caution and careful attention.

4차 산업혁명 시대의 중국미술시장 분석과 대응전략

서희연 한국문화예술경영학회 2017 문화예술경영학연구 Vol.10 No.2