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스트렙토조토신 유발 인슐린 의존형 당뇨 흰쥐 모형의 와우 전정 신경절과 신경핵에서 신경세포 크기와 면적비의 변화
서한규,황순재,이대일,오칠환 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.1
The central nervous system (CNS) has been known to be spared from the target of late complication of diabeter, which are the retinopathy, nephropathy and peripheral neuropathy and to be evident within 10~20 years after the onset on the disease. However recently amny clinical and experimental studies, the CNS is also the target organ of diabetic complications and symtoms or signs of CNS involvement that are evident before the appearance of symptoms of the classical target organs. Among the many symptoms, vertigo/dizziness and fluctuating hearing impairment, the inner ear symptoms, are the first and the most frequent symptoms. Therefore many authors are interested in detecting preclinical signs of diabetic complication at an early stage of the disease to prevent a severe CNS insults. This study was designed to investigate whether the inner ear dysfunction was the result from diabetic complications in an early stage of the disease; and to prove the central cochleovestibular system that is responsible for the inner ear symptoms in diabeters. Therefore we made an animal model of diabetes by intraperitoneal injection of streptozotocin (65mg/kg) and severed after 4~18 weeks and examined the cell size and cellular area in in cochleovestibular ganglia and nuclei; then compared the result with the interpeak latency of auditory brainstem response audiometry(ABR). In results, the interpeak latency between wave Ⅰand Ⅲ (Ⅰ-Ⅲ IPL) and Ⅰ-Ⅴ IPL were delayed beyond 2 standard deviations value in 10 of 31 diabetic animals and the cells in spiral ganglion of the middle and basal turn of cochlea that were reduced in both cell size and cellular area significantly (p<0.05). Whereas in cochlear nuclei, there was no one which had significant reduction of cell size and cellular area and only one of the seven 18 weeks diabetic animals showed a significant decrease of cell size and cellular area in superior vestibular nucleus. These findings mean that the CNS pathology is responsible for the inner ear symptoms in diabetes and the inner ear symptoms may be the first sign of CNS involvement of complicated diabetes and stress the value of the short latency evoked potential such as ABR as the sensitive and early diagnostic approach to the study of preclinical diabetic complications.
말초 전정기관의 중추투사에서 생물학적 표지자로서 Fos단백의 유용성
서한규,박호정,우정수,유동희,임현호,황순재 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.3
Fos, the protein product of c-fos gene, has been known to be rapidly expressed in neurons following various external and internal stimuli and this protein expression has been used as a neural activation marker in many fields. This experiment was performed to determine the afferent neural pathway from the peripheral vestibular receptors could be mapped by detection of expressed Fos protein. The experimental animals received centripetal off-axis rotational stimulation to stimulate the otolith organs and sinusoidal rotary stimulation to stimulate the lateral semicircular canals. Thirty minutes after stimulation, the subjects were sacrificed and their brainstems were processed for immunohistochemistry to detect Fos expression. Fos proteins were strongly expressed in the medial, inferior and the y-group vestibular nuclei following otolith stimulation and also were expressed in the superior, dorsal part of medial, inferior vestibular nuclei and interstitial nuclei of vestibular nerve following sinusoidal acceleration. The results suggested that the afferent pathway from peripheral vestibular endorgan can be successfully mapped with detection of Fos expression and c-fos gene is an useful neural activity marker in vestibular system.