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만성 B형간염 환자에서 심한 피부 발진을 보인 라미부딘 부작용 1예
김석배 ( Seok Bae Kim ),서평주 ( Pyoung Ju Seo ),백두산 ( Du San Baik ),윤세영 ( Se Young Yun ),김병하 ( Byung Ha Kim ),신정은 ( Jung Eun Shin ),김홍자 ( Hong Ja Kim ),송일한 ( Il Han Song ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.4
Lamivudine is widely used for the treatment of chronic hepatitis B infection because of it`s remarkable antiviral efficacy and safety. We report a case of severe skin eruption caused by lamivudine. A 47-year-old female was admitted because of jaundice and itching sensation. She was diagnosed as chronic hepatitis B infection a few years ago but did not receive any specific treatment. Laboratory data showed acute deterioration of chronic hepatitis B infection. We prescribed lamivudine as a rescue therapy. Her general condition improved and lab data showed improvement in liver function test thereafter. However, she complained of severe skin eruption and itching sensation a few days after the discharge. We stopped lamivudine because the symptoms did not improve despite the use of anti-histamine. Skin biopsy showed interface dermatitis. After stopping lamivudine, her symptoms improved. However, the skin eruption developed again after lamivudine was restarted. Adefovir was used instead, and the patient did not experience any further skin problems since then. (Korean J Gastroenterol 2006;48:281-285)
서승철 ( Seung Chul Suh ),서평주 ( Pyoung Ju Seo ),박현경 ( Hyun Kyung Paark ),신철민 ( Cheol Min Shin ),조현진 ( Hyun Jin Jo ),김현영 ( Hyun Young Kim ),이상협 ( Sang Hyub Lee ),박영수 ( Young Soo Park ),황진혁 ( Jin Hyeok Hwa 대한소화기학회 2012 대한소화기학회지 Vol.60 No.6
목적: 대장게실출혈은 하부위장관 출혈의 30-40%를 차지하며 이 중 3-5%에서는 대량출혈로 나타난다. 이번 연구에서는 대장내시경검사를 통해 게실이 확인된 환자들을 대상으로 대장게실출혈의 위험인자에 대하여 후향적으로 알아보고자 하였다. 대상 및 방법: 대장게실증, 대장게실염, 대장게실출혈의 상병명을 통해 확인된 1,003명 중 대장내시경에서 대장게실이 확인된 216명을 대상으로 출혈이 확인되었거나 추정된 환자군과 출혈이 없는 환자군으로 나누어 나이, 성별, 게실 위치에 따른 차이를 비교하였고 동맥경화증 관련 기저질환, 흡연 및 음주 그리고 복용약제 등의 위험인자에 대하여 두 군 간의 차이를 평가하였다. 결과: 216명 중 게실출혈은 35명에서 관찰되었다(16.2%). 평균 연령은 출혈군에서 비출혈군에 비해 유의하게 높았으나 남녀비는 두 군 간에 유의한 차이는 없었다. 두 군에서 모두 우측 대장게실의 비율이 높았으며 게실이 양측성으로 존재하는 경우 출혈 환자의 비율이 더 높았다. 고령, 양측성 게실, 고혈압, 당뇨병, 허혈성 심장질환, 비만이 있을 때 그리고 아스피린, NSAIDs, 칼슘통로차단제의 복용이 출혈과 유의한 관계를 보였다. 다변량 분석에서 아스피린과 양측성 대장게실증이 출혈의 독립적인 위험인자로 나타났다. 결론: 대장게실이 양측에 존재하거나 또는 아스피린을 복용중인 환자에서 대장게실 출혈의 위험성이 증가하므로 이에 대한 주의와 함께 환자에 대한 교육이 필요할 것으로 생각된다. Background/Aims: Colonic diverticular bleeding cases account for 30-40% of the lower gastrointestinal bleeding, among which, 3-5% appear to be massive bleeding. The purpose of this study was to evaluate the risk factors for colonic diverticular bleeding diagnosed by colonoscopic examination. Methods: Among the 1,003 patients, who were identified to have colonic diverticulosis including sleeding by diverticulitis and diverticular bleeding coding search, 216 patients had diverculosis, and they were divided into two groups: one with diverticular bleeding, and the other without bleeding. We evaluated the potential risk factors for diverticular bleeding, based on age, gender, location of diverticulum, comorbidities related to atherosclerosis, smoking, alcohol and medications, and compared them between both groups. Results: Among the 216 patients, we observed colonic diverticular bleeding in 35 patients (16.2%). The mean age of the bleeding group was significantly older than that of non-bleeding group. No difference was observed regarding gender ratio. Right colonic diverticula were common in both groups, but there were higher proportion of patients with bleeding in bilateral diverticuosis. Old age, bilateral diverticulosis, presence of atherosclerosis related diseases (hypertension, diabetes mellitus, ischemic heart disease, obesity), use of aspirin, NSAIDs and calcium channel blocker, increased the risk of bleeding. In a multivariate analysis, use of aspirin and bilateral diverticulosis were identified as independent risk factors for colonic diverticular bleeding. Conclusions: Since the patients who took aspirin and/or had bilateral colonic diverticulosis increased the risk of bleeding from divertuculi. As such, caution and education of patients are required.
간세포암종 진단에 유의한 PIVKA-II 값의 제시- ROC Curve를 이용하여 -(논평참조)
김명진 ( Myong Jin Kim ),배강우 ( Kang Woo Bae ),서평주 ( Pyoung Ju Seo ),정인국 ( In Kook Jeong ),김정혁 ( Jung Hyuk Kim ),이보한 ( Bo Han Lee ),방기태 ( Ki Tae Bang ),김동우 ( Dong Woo Kim ),송일한 ( Il Han Song ) 대한간학회 2006 Clinical and Molecular Hepatology(대한간학회지) Vol.12 No.3
위장관 ; 경도 및 중등도 활동성 궤양성 대장염 환자에서의 VSL#3의 효능
이지현 ( Ji Hyun Lee ),문규 ( Gyoo Moon ),권혁진 ( Hyeok Jin Kwon ),정우진 ( Woo Jin Jung ),서평주 ( Pyoung Ju Seo ),백태윤 ( Tai Yoon Baec ),이주형 ( Ju Hyeong Lee ),김현식 ( Hyun Shig Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2
Background/Aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC. Methods: Twenty-four eligible patients with mild to moderate UC received open-label VSL#3 4 sachets daily in 2 divided doses for 8 weeks. The disease activity pre- and post-VSL#3 therapy was assessed by ulcerative colitis disease activity score and colonic tissue cytokine profiling done at baseline and at week 8. Results: Twenty-four patients (mean age, 43.7 years; range, 20-70 years; male/female, 15/9) were enrolled and 2 patients did not have the final endoscopic assessment. A total of 22 patients were analyzed. Intent to treat analysis demonstrated remission in 45.8% of subjects (n=11); partial response in 20.8% (n=5); no change or worse in 25.0% (n=6) of subjects. The mean ulcerative colitis disease activity index (UCDAI) scores decreased from 7.09±1.81 to 1.45±1.29 in patients with a remission (p<0.001). The mean endoscopic scores had also significantly decreased from 1.91±0.54 to 0.63±0.50 in patients with a remission (p<0.001). The concentrations of colonic cytokines did not change significantly during treatment in patients with a remission. Conclusions: Our study demonstrated that VSL#3 is effective in achieving clinical responses and remissions in patients with mild-to moderately active UC, further supporting the potential role in UC therapy. (Korean J Gastroenterol 2012;60:94-101)
김진주 ( Jin Joo Kim ),김나영 ( Nayoung Kim ),이병환 ( Byoung Hwan Lee ),강정묵 ( Jung Mook Kang ),서평주 ( Pyoung Ju Seo ),임민경 ( Min Kyoung Lim ),권정희 ( Jung Hee Kwon ),송병준 ( Byeong Jun Song ),이정원 ( Jung Won Lee ),이 대한소화기학회 2010 대한소화기학회지 Vol.56 No.4
Background/Aims: Peptic ulcer disease (PUD) is one of the common gastrointestinal diseases, and its medical management has been developed so much that the incidence of its serious complications, such as bleeding and perforation, are declining significantly. Its prevalence in Korea is not definitely decreased, probably due to increasing proportion of elderly patients and their rising usage of non-steroidal anti-inflammatory drugs (NSAIDs) and aspirins. This study was conducted to identify the risk factors for development and recurrence of peptic ulcer disease in Korea. Methods: From 2003 to 2008, upper gastrointestinal endoscopy and detailed personal questionnaires were performed for patients who visited Department of Gastroenterology at Seoul National University Bundang Hospital. In total, 475 PUD patients and 335 non-ulcer dyspepsia patients were included. The results of questionnaires and repeated upper gastrointestinal endoscopy at initial diagnosis time and follow-up periods were analyzed. Results: Multivariable analysis showed that male, H. pylori infection, NSAIDs use and smoking were risk factors for the development of PUD. The use of proton pump inhibitors (PPIs) and H2 receptor antagonists has significantly reduced the risk of PUD in patients who had taken NSAIDs and/or aspirins. H. pylori infection was found as the only risk factor for the recurrence of PUD. Conclusions: For the old patients who are taking drugs, such as NSAIDs and aspirins, concomitant use of PPIs or H2 receptor antagonists should be considered to protect from the development of PUD. H. pylori eradication has been confirmed again to be essential for the treatment of PUD patients infected with H. pylori. (Korean J Gastroenterol 2010;56:220-228)