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서영진,Kelly Hunt 한국유방암학회 2008 Journal of breast cancer Vol.11 No.2
Recently, many preclinical and clinical researches have focused on the possible roles of new therapeutic modalities to enhance current treatment efficacy or to extend the current limitations against breast cancer treatment. Th melanoma differentiation-associated gene-7 (MDA-7), now classified as a member of the interleukin (IL)-10 gene family (IL-24), has attracted attentions from several investigators for its unique ability to act against various cancers including breast cancer. In addition to MDA-7, highly selective cyclooxygenase-2 (COX-2) inhibitors, have continuously demonstrated possible anticancer effects against various cancers even though theray with many of the inhibitors has resulted in major set backs due to complications after long-term use. However, few have performed to demonstrate the synergistic effects of these two efficient treatment options or to demonstrate preventive measures to reduce the size of tumors. We summarize important results and our experience related to the use of a selective cyclooxygenase 2 inhibitor and adenovirus-mediated delivery of MDA-7.
서영진,강세구 한국유방암학회 2010 Journal of breast cancer Vol.13 No.3
to enhance radiosensitivity in various cancer cells in vitro. We expected to synergistically enhance radiosensitivity by combing celecoxib and Ad-mda7 in breast cancer cells in vitro. Methods: MDA-MB-436 and MDA-MB-468 human breast cancer cells were exposed to different doses (0, 2, 4, and 6 Gy) of radiation with or without pretreatment with either Ad-mda7 or celecoxib alone, or with the combination for three days prior to irradiation. Clonogenic cell survival assay was used to compare the radiosensitizing effect. Fluorescence activated cell sorting analysis was performed to assess cell cycle changes and the subdiploid cell population. We determined the prostaglandin E2 (PGE2) concentration before and after the irradiation (2 Gy, 24 hours). We performed western blot analysis of Akt, phosphorylated Akt,β-catenin, and cyclooxygenase-2 (COX-2). Results: At the sublethal dose of celecoxib and Ad-mda7, the combination showed significantly enhanced radiosensitivity. The enhancement factor for the combination treatment was 1.44 in MDAMB-468 cells and 1.75 in MDA-MB-436 cells. There were an increased percentage of apoptotic cells in the combination therapy group as compared to the controls, but this was not statistically significant. Cell cycle analysis demonstrated an increase in the G2/M phase of the cell cycle in the combination group compared with controls. The concentration of PGE2 was significantly decreased after the irradiation in both cell lines compared to the controls. Western blot analysis confirmed that this combination treatment effectively suppress the expression of Akt, phosphorylated Akt, and COX-2in those cell lines, except β-catenin. Conclusion: Cotreatment of Ad-mda7 plus celecoxib definitely showed radioenhancing effect. We presumed that this effect may be the arrest of the cells at the radiosensitive G2/M phase of the cell cycle.
Causes of necrotic features in fine-needle aspirates from cervical lymph nodes
서영진,신형찬,이혜원,정혜라 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.1
Background: Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult. Methods: We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed necrotic findings at Keimyung University Dongsan Hospital in Daegu, Korea, from 2003–2017. Each specimen was evaluated and analyzed in association with the clinical findings, biopsy findings, and/or other ancillary tests, including acid-fast bacilli staining and molecular testing for Mycobacterium tuberculosis. Results: When necrotic features were noted upon cervical LN FNA cytology, the most common pathologic LN FNA category was necrosis alone (31.5%). The second most common category was granulomatous inflammation (31.3%), followed by Kikuchi disease (20.0%) and malignant neoplasm (8.7%). In cases where the cervical LN FNA revealed necrosis alone, the most common final diagnosis was tuberculosis. In young patients, Kikuchi disease should be considered as one cervical LN FNA category, while metastatic carcinoma should be suspected in older patients. Conclusions: Even when necrosis alone is observed in LN FNA cytology, it is important to determine the cause through further evaluation.
Painless Posterior Thigh Mass as a Presentation of Metastatic Breast Cancer
서영진,조현민,고명수,이지혜,정원상,최현주,오세정 한국유방암학회 2010 Journal of breast cancer Vol.13 No.4
Soft tissue metastasis clinically presenting as either painless subcutaneous or painful intramuscular nodules is extremely rare and may lead to an errant clinical suspicion of sarcoma. In general, most soft tissue metastasis comes from lung carcinoma; however, to date, there have been no reports of a posterior thigh mass just beneath the skin metastasizing from breast cancer. Here, we report a case of distant soft tissue metastasis presenting as a painless solitary left posterior thigh mass measuring 1.5 cm in diameter, which was later shown by positron emission tomography-computed tomography (PET-CT) to have multiple simultaneous mediastinal lymph node metastases. Eleven months ago, the patient had undergone curative breast-conserving surgery (BCS) for cancer of her left breast. At that time, her tumor showed a triple negative phenotype. Initial PET-CT right before the BCS had shown no metastasis. After histological and radiologic evaluation for the metastases, she decided to have systemic chemotherapy.
Sn-3.0Ag-0.5Cu 솔더 접합부 미세구조와 기계적 특성에 미치는 솔더 부피와 크기의 영향
서영진,허민행,이동환,윤정원 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.11
최근 스마트폰, 태블릿 PC와 같은 휴대용 전자기기의 소형화 및 경량화와 플렉시블, 웨어러블 전자기기 같은 새로운 시도가 진행되면서 반도체 패키지의 소형화에 대한 중요성이 크게 부각되고 있다. 이에 따라 반도체 부품과 기판소재를 어셈블리하는 접합 소재의 소형화 또한 중요해지고 있고 반도체 칩의 적층 및 모바일 디바이스의 고밀도화 등 다양한 분야에서의 적용을 필요로 하고 있다. 이들 첨단 반도체 전자 소자 및 제품의 제조를 위해서는 전통적으로 솔더링 및 표면실장 접합 기술이 사용되어져 왔으며, 이를 공정에서는 다양한 부품 및 크기의 접합부가 형성된다. 따라서, 이들 다양한 크기 및 부피를 가지는 솔더 접합부의 특성에 대한 이해 및 관찰이 관련 분야 제품의 특성 및 신뢰성을 이해하는데 있어서 필수적이다. 이러한 추세에 따라 소형화 되는 접합 소재에 대응하기 위해 Sn-3.0Ag-0.5Cu 솔더볼 크기에 따른 미세구조 및 기계적 특성 평가 연구가 수행 되었다. 본 연구에서는 OSP(Organic Solderability Preservative) 표면처리된 PCB 기판과 서로 다른 4가지 종류의 직경(600μm, 450μm, 300μm, 200μm)을 가지는 솔더볼을 사용하여 연구를 진행하였다. 크기별로 솔더볼을 기판 패드상에 위치 시킨 후 리플로우 장비를 이용하여 250°C에서 약 1분 30초간 리플로우 공정을 시행하여 접합을 진행하였으며 미세구조와 기계적 특성에 미치는 솔더 부피의 영향을 확인하기 위해 전단 시험 장비(Dage4000)를 사용하여 전단 시험을 수행하였다. 전단 시험을 통해 접합부의 기계적 신뢰성을 평가하여 솔더볼 크기별 접합부의 강도를 분석하였고, 파단면 관찰을 통해 금속간 화합물의 형성에 미치는 부피 효과에 대해 분석하였다. 조건별 연구 분석 결과를 통해 솔더볼의 부피 및 크기와 접합부 특성의 상관관계를 평가하였다.